1.1.1.205: IMP dehydrogenase

This is an abbreviated version, for detailed information about IMP dehydrogenase, go to the full flat file.

Reaction

IMP
+
NAD+
+
H2O
=
XMP
+
NADH
+
H+

Synonyms

dehydrogenase, inosinate, EC 1.2.1.14, guaB2, IMD2, IMD3, IMD4, IMP dehydrogenase, IMP DH, IMP oxidoreductase, IMP-DH, IMP:NAD oxidoreductase, IMP:NAD+ oxidoreductase, IMPD, IMPDH, IMPDH II, IMPDH-1, IMPDH-B, IMPDH-S, IMPDH1, IMPDH2, inosinate dehydrogenase, inosine 5' monophosphate dehydrogenase, inosine 5'-monophosphate dehydrogenase, inosine 5'-monophosphate dehydrogenase 2, inosine 5'-phosphate dehydrogenase, inosine 5-monophosphate dehydrogenase, inosine 5-monophosphate dehydrogenase type I, inosine 5 -monophosphate dehydrogenase, inosine monophosphate dehydrogenase, inosine monophosphate oxidoreductase, inosine-5'-monophosphate dehydrogenase, inosine-5'-phosphate dehydrogenase, inosinic acid 5-monophosphate dehydrogenase, inosinic acid dehydrogenase, mpaF, Raspberry protein, SOI12, Superoxide-inducible protein 12, type 1 inosine monophosphate, type 2 inosine monophosphate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.205 IMP dehydrogenase

pH Range

pH Range on EC 1.1.1.205 - IMP dehydrogenase

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.7 - 9
-
pH 6.7: about 40% of activity maximum, pH 9.0: about 55% of activity maximum
7 - 9
-
pH 7: about 45% of activity maximum, pH 9: about 85% of activity maximum
7.5 - 8.7
-
pH 7.5: about 60% of activity maximum, pH 8.7: about 40% of activity maximum
7.5 - 9.5
-
pH 7.5: about 55% of activity maximum, pH 9.5: about 70% of activity maximum
7.5 - 9
-
pH 7.5: about 50% of activity maximum, pH 9: about 50% of activity maximum
8.5 - 10
-
pH 8.5: about 60% of activity maximum, pH 10: about 75% of activity maximum
additional information
-
pH-dependence of wild-type enzyme and mutant Y419F, overview