1.1.1.205: IMP dehydrogenase

This is an abbreviated version, for detailed information about IMP dehydrogenase, go to the full flat file.

Reaction

IMP
+
NAD+
+
H2O
=
XMP
+
NADH
+
H+

Synonyms

dehydrogenase, inosinate, EC 1.2.1.14, guaB2, IMD2, IMD3, IMD4, IMP dehydrogenase, IMP DH, IMP oxidoreductase, IMP-DH, IMP:NAD oxidoreductase, IMP:NAD+ oxidoreductase, IMPD, IMPDH, IMPDH II, IMPDH-1, IMPDH-B, IMPDH-S, IMPDH1, IMPDH2, inosinate dehydrogenase, inosine 5' monophosphate dehydrogenase, inosine 5'-monophosphate dehydrogenase, inosine 5'-monophosphate dehydrogenase 2, inosine 5'-phosphate dehydrogenase, inosine 5-monophosphate dehydrogenase, inosine 5-monophosphate dehydrogenase type I, inosine 5 -monophosphate dehydrogenase, inosine monophosphate dehydrogenase, inosine monophosphate oxidoreductase, inosine-5'-monophosphate dehydrogenase, inosine-5'-phosphate dehydrogenase, inosinic acid 5-monophosphate dehydrogenase, inosinic acid dehydrogenase, mpaF, Raspberry protein, SOI12, Superoxide-inducible protein 12, type 1 inosine monophosphate, type 2 inosine monophosphate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.205 IMP dehydrogenase

KI Value

KI Value on EC 1.1.1.205 - IMP dehydrogenase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0004 - 0.0011
(5E)-N-hydroxy-7-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-5-methylhept-5-enamide
0.0011 - 0.0014
2'-methylthiazole-4-carboxamide adenine dinucleotide
0.115
2-beta-D-ribofuranosylthiazole-4-carboxamide 5'-phosphate
-
pH 7.4, 37C
0.001
2-[2-(Z)-fluorovinyl]-inosine 5'-phosphate
-
-
0.00052 - 0.00066
3'-methylthiazole-4-carboxamide adenine dinucleotide
0.000034 - 0.000077
6-((E)-4-(((1-(50-deoxy-adenosin-50-yl)-1H-1,2,3-triazol-4-yl)-methyl)amino)-3-methylbut-2-en-1-yl)-7-hydroxy-5-methoxy-4-methylisobenzofuran-1(3H)-one
0.000044 - 0.0015
6-((E)-4-(4-(adenosin-50-yl)methyl-1H-1,2,3-triazol-1-yl)-3-methylbut-2-en-1-yl)-7-hydroxy-5-methoxy-4-methylisobenzofuran-1(3H)-one
0.078
6-chloroinosine 5'-phosphate
-
-
0.26
6-Cl-IMP
-
-
0.14
6-thio-IMP
-
-
0.000007
7-methoxy-6-(1,3-oxazol-5-yl)-2-phenylquinolin-4(1H)-one
-
-
0.44 - 0.82
9-(5-deoxy-5-([(([2-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)ethoxy]sulfonyl)methyl)sulfonyl]amino)-b-L-ribofuranosyl)-2-ethyl-9H-purin-6-amine
0.18 - 0.52
9-(5-deoxy-5-([(([2-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)ethoxy]sulfonyl)methyl)sulfonyl]amino)-b-L-ribofuranosyl)-2-ethynyl-9H-purin-6-amine
0.31 - 0.66
9-(5-deoxy-5-([(([2-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)ethoxy]sulfonyl)methyl)sulfonyl]amino)-b-L-ribofuranosyl)-2-phenyl-9H-purin-6-amine
0.17 - 0.35
9-(5-deoxy-5-([(([2-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)ethoxy]sulfonyl)methyl)sulfonyl]amino)-b-L-ribofuranosyl)-9H-purin-6-amine
2 - 50
ADP
0.282 - 0.854
AMP
0.000006
AVN944
-
;
0.25 - 0.33
C2-mycophenolic adenine dinucleotide
-
pH 8.0, 25C
0.38 - 0.52
C4-mycophenolic adenine dinucleotide
-
pH 8.0, 25C
0.00038
CH2-SAD
pH 8.0, 37C, recombinant enzyme
0.00098
CH2-TAD
pH 8.0, 37C, recombinant enzyme
0.0997
curcumin
pH not specified in the publication, temperature not specified in the publication
0.027
EAD
-
-
0.002 - 0.016
EICARMP
0.003 - 0.0031
eicosadienoic acid
0.038 - 0.056
FFAD
0.05 - 0.21
GMP
0.000001 - 0.00005
imidazo[4,5-e][1,4]diazapine
4.5
inosine 5'-phosphate
pH 8.0, 37C, recombinant enzyme
0.000007
merimepodib
-
;
0.0000005 - 0.000008
mizoribine
0.0033
mizoribine 5'-monophosphate
pH 8.0, 25C
0.00000001 - 0.0000002
mizoribine 5'-phosphate
0.0005 - 0.0115
mizoribine monophosphate
0.0000002 - 10
Mycophenolic acid
0.000382 - 0.000511
mycophenolic acid-acyl-glucuronide
0.00003 - 0.00007
mycophenolic hydroxamic acid
0.000071 - 0.00069
myelophenolic acid
-
0.0017 - 0.005
N-hydroxy-N'-[3-methoxy-4-(1,3-oxazol-2-yl)phenyl]octanediamide
0.0000032
N-[4-chloro-3-(trifluoromethyl)phenyl]-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
-
pH not specified in the publication, temperature not specified in the publication
0.6 - 6.8
NAD+
0.094 - 0.38
NADH
0.02 - 0.037
P1-(7-hydroxy-6-(ethyl-2-yl)-5-methoxy-4-methylphthalan-1-one)methylenephospho-P2-(adenosin-5'-yl)phosphonate
-
pH 8.0, 25C
0.06 - 0.087
P1-(adenosine-5'-yl)methylenephospho-P2-(7-hydroxy-6-(ethyl-2-yl)-5-methoxy-4-methylphthalan-1-one)phosphonate
-
pH 8.0, 25C
0.000095 - 0.0085
P1-(thiazofurin-5'-yl)-P2-(adenosyl-5'-yl)-alpha,beta-methylene diphosphate
0.000007 - 0.000027
P1-(tiazofurin-5'-yl)-P2-(2-aminoadenosin-5'-yl) diphosphate
0.000001 - 0.000014
P1-(tiazofurin-5'-yl)-P2-(2-ethyladenosin-5'-yl) diphosphate
0.00001 - 0.000049
P1-(tiazofurin-5'-yl)-P2-(2-ethynyladenosin-5'-yl) diphosphate
0.000019 - 0.000084
P1-(tiazofurin-5'-yl)-P2-(2-iodoadenosin-5'-yl) diphosphate
0.00002 - 0.000143
P1-(tiazofurin-5'-yl)-P2-(2-phenyladenosin-5'-yl) diphosphate
0.00011
P1-(tiazofurin-5'-yl)-P2-(adenosin-5'-yl) diphosphate
-
isoform IMPDH1, pH 8.0, 25C; isoform IMPDH2, pH 8.0, 25C
0.02 - 0.04
P1-[7-hydroxy-6-(hydroxyethyl)-5-methoxy-4-methylphthtalan-1-one-2-yl]-P2-(2-ethyladenosin-5'-yl)methylenebis(phosphonate)
0.07 - 0.11
P1-[7-hydroxy-6-(hydroxyethyl)-5-methoxy-4-methylphthtalan-1-one-2-yl]-P2-(2-phenyladenosin-5'-yl)methylenebis(phosphonate)
0.25 - 0.33
P1-[7-hydroxy-6-(hydroxyethyl)-5-methoxy-4-methylphthtalan-1-one-2-yl]-P2-(adenosin-5'-yl)methylenebis(phosphonate)
0.00025 - 0.0032
ribavirin 5'-monophosphate
0.000065 - 0.006
ribavirin monophosphate
0.0018
SAD
pH 8.0, 37C, recombinant enzyme
0.00002 - 0.00003
Selenazofurin
0.00058 - 0.0011
SFAD
0.0018
TAD
pH 8.0, 37C, recombinant enzyme
0.00043 - 0.0007
TFAD
0.000058 - 0.0013
thiazole-4-carboxamide adenine dinucleotide
0.00043 - 300
tiazofurin
0.000006 - 0.000014
VX-148
0.000007 - 0.00001
VX-497
0.03 - 0.32
xanthosine 5'-phosphate
0.026
XMP
-
pH 7.5, 25C
additional information
additional information
-