Information on EC 1.1.1.205 - IMP dehydrogenase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY
1.1.1.205
-
RECOMMENDED NAME
GeneOntology No.
IMP dehydrogenase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
adenosine nucleotides degradation I
-
Biosynthesis of secondary metabolites
-
Drug metabolism - other enzymes
-
guanosine ribonucleotides de novo biosynthesis
-
Metabolic pathways
-
Purine metabolism
-
urate biosynthesis/inosine 5'-phosphate degradation
-
SYSTEMATIC NAME
IUBMB Comments
IMP:NAD+ oxidoreductase
The enzyme acts on the hydroxy group of the hydrated derivative of the substrate.
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
dehydrogenase, inosinate
-
-
-
-
EC 1.2.1.14
-
-
formerly
-
IMP dehydrogenase
-
-
-
-
IMP oxidoreductase
-
-
-
-
IMP oxidoreductase
-
-
IMP:NAD+ oxidoreductase
-
-
IMPD
-
-
-
-
IMPDH
-
-
-
-
IMPDH
P49058
-
IMPDH
P12268, P20839
-
IMPDH
P21620
-
IMPDH
Q12658
-
IMPDH
P42851
-
IMPDH
Streptococcus suis 2
-
-
-
IMPDH
Q4VRV8
-
IMPDH
P50097
-
IMPDH
P50098
-
IMPDH II
-
-
IMPDH II
P12268
-
IMPDH-1
-
-
IMPDH-S
Q4VRV6
-
IMPDH1
-
-
IMPDH1
P20839
-
IMPDH2
P12268
-
inosinate dehydrogenase
-
-
-
-
inosinate dehydrogenase
-
-
inosine 5' monophosphate dehydrogenase
P12268
-
inosine 5'-monophosphate dehydrogenase
-
-
-
-
inosine 5'-monophosphate dehydrogenase
-
-
inosine 5'-monophosphate dehydrogenase
P49058
-
inosine 5'-monophosphate dehydrogenase
-
-
inosine 5'-monophosphate dehydrogenase
-
-
inosine 5'-monophosphate dehydrogenase
Q8T6T2
-
inosine 5'-monophosphate dehydrogenase
-
-
inosine 5'-monophosphate dehydrogenase
-
-
inosine 5'-monophosphate dehydrogenase
-
-
inosine 5'-monophosphate dehydrogenase
-
-
inosine 5'-monophosphate dehydrogenase
P12268, P20839
-
inosine 5'-monophosphate dehydrogenase
P21620
-
inosine 5'-monophosphate dehydrogenase
-
-
inosine 5'-monophosphate dehydrogenase
-
-
inosine 5'-monophosphate dehydrogenase
Q12658
-
inosine 5'-monophosphate dehydrogenase
-
-
inosine 5'-monophosphate dehydrogenase
-
-
inosine 5'-monophosphate dehydrogenase
-
-
inosine 5'-monophosphate dehydrogenase
-
-
inosine 5'-monophosphate dehydrogenase
P0C0H6
-
inosine 5'-monophosphate dehydrogenase
-
-
inosine 5'-monophosphate dehydrogenase
-
-
inosine 5'-monophosphate dehydrogenase
P50097
-
inosine 5'-monophosphate dehydrogenase
P50098
-
inosine 5'-monophosphate dehydrogenase 2
-
-
inosine 5'-phosphate dehydrogenase
-
-
inosine 5-monophosphate dehydrogenase
-
-
inosine 5-monophosphate dehydrogenase
-
-
inosine 5-monophosphate dehydrogenase
Streptococcus suis 2
-
-
-
inosine 5-monophosphate dehydrogenase type I
-
-
inosine 5’ -monophosphate dehydrogenase
-
-
inosine monophosphate dehydrogenase
-
-
-
-
inosine monophosphate dehydrogenase
-
-
inosine monophosphate dehydrogenase
P12268, P20839
-
inosine monophosphate dehydrogenase
-
-
inosine monophosphate dehydrogenase
-
-
inosine monophosphate oxidoreductase
-
-
-
-
inosine monophosphate oxidoreductase
-
-
inosine-5'-monophosphate dehydrogenase
-
-
inosine-5'-phosphate dehydrogenase
-
-
-
-
inosinic acid 5’-monophosphate dehydrogenase
-
-
inosinic acid dehydrogenase
-
-
-
-
Raspberry protein
-
-
-
-
SOI12
-
-
-
-
Superoxide-inducible protein 12
-
-
-
-
type 1 inosine monophosphate
-
-
type 2 inosine monophosphate dehydrogenase
-
-
CAS REGISTRY NUMBER
COMMENTARY
9028-93-7
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
JCM 2152 and ts-4
-
-
Manually annotated by BRENDA team
M strain
-
-
Manually annotated by BRENDA team
strain NA7821 and NA6128
-
-
Manually annotated by BRENDA team
Bacillus subtilis M
M strain
-
-
Manually annotated by BRENDA team
Bacillus subtilis NA7821
strain NA7821 and NA6128
-
-
Manually annotated by BRENDA team
strain CAI4, gene IMH3
Uniprot
Manually annotated by BRENDA team
Candida albicans CAI4
strain CAI4, gene IMH3
Uniprot
Manually annotated by BRENDA team
vero cell-line infected with vaccina virus and parainfluenza virus type 3 strain C243
-
-
Manually annotated by BRENDA team
chinese hamster
-
-
Manually annotated by BRENDA team
Chinese hamster type 2
-
-
Manually annotated by BRENDA team
chinese hamster, MPA resistant VM2 variant cells
-
-
Manually annotated by BRENDA team
hamster type 2
-
-
Manually annotated by BRENDA team
MMRL2651, subtype naturally resistant to inhibition by mycophenolic acid
UniProt
Manually annotated by BRENDA team
Cryptococcus neoformans H99
-
-
-
Manually annotated by BRENDA team
; wild type and guaA mutants
-
-
Manually annotated by BRENDA team
derepressed mutant
-
-
Manually annotated by BRENDA team
guaA strain PL 1068
-
-
Manually annotated by BRENDA team
chicken
-
-
Manually annotated by BRENDA team
IMPDH 1
UniProt
Manually annotated by BRENDA team
IMPDH 2
UniProt
Manually annotated by BRENDA team
IMPDH II
-
-
Manually annotated by BRENDA team
IMPDH type II
-
-
Manually annotated by BRENDA team
IMPDH1
UniProt
Manually annotated by BRENDA team
IMPDH2
UniProt
Manually annotated by BRENDA team
isoform IMPDH 1
UniProt
Manually annotated by BRENDA team
isoform IMPDH 2
UniProt
Manually annotated by BRENDA team
isoform IMPDH1
UniProt
Manually annotated by BRENDA team
isoform IMPDH2
UniProt
Manually annotated by BRENDA team
isoforms IMPDH1 and IMPDH2
-
-
Manually annotated by BRENDA team
isozyme IMPDH II
-
-
Manually annotated by BRENDA team
isozyme IMPDH2
-
-
Manually annotated by BRENDA team
mutants of type II; type II
-
-
Manually annotated by BRENDA team
patients with kidney transplantation
-
-
Manually annotated by BRENDA team
renal transplant patients
-
-
Manually annotated by BRENDA team
stable kidney transplant recipients
-
-
Manually annotated by BRENDA team
thiopurine-treated patients with inflammatory bowel disease
-
-
Manually annotated by BRENDA team
type 1 enzyme, retinal-specific isoforms IMPDH1(546) and IMPDH1(595) and canonical isoform IMPDH1(514)
-
-
Manually annotated by BRENDA team
type I and type II
-
-
Manually annotated by BRENDA team
type I and type II isozymes
-
-
Manually annotated by BRENDA team
type I isozyme
UniProt
Manually annotated by BRENDA team
type II
UniProt
Manually annotated by BRENDA team
type II IMPDH isozyme
-
-
Manually annotated by BRENDA team
type II isozyme
-
-
Manually annotated by BRENDA team
strain MPA100
-
-
Manually annotated by BRENDA team
Leishmania donovani MPA100
strain MPA100
-
-
Manually annotated by BRENDA team
IMPDH type II
-
-
Manually annotated by BRENDA team
IMPDH2
UniProt
Manually annotated by BRENDA team
strains CDC1551 and H37Rv
-
-
Manually annotated by BRENDA team
no activity in Giardia lamblia
-
-
-
Manually annotated by BRENDA team
no activity in Trichomonas vaginalis
-
-
-
Manually annotated by BRENDA team
Parainfluenza virus
type 3, strain C243, propagated in Vero cells
-
-
Manually annotated by BRENDA team
var. Canners' Perfection
-
-
Manually annotated by BRENDA team
; hepatoma 3924A
-
-
Manually annotated by BRENDA team
hepatoma
-
-
Manually annotated by BRENDA team
hepatoma 3924A
-
-
Manually annotated by BRENDA team
Yoshida sarcoma ascites cells
-
-
Manually annotated by BRENDA team
type 2 strain
-
-
Manually annotated by BRENDA team
Streptococcus suis 2
type 2 strain
-
-
Manually annotated by BRENDA team
large splicing variant IMPDH; strains RH and RHDELTATHX, opportunistic apicomplexan parasite, two splicing variants, a short and a large one
SwissProt
Manually annotated by BRENDA team
short splicing variant IMPDH-S; strains RH and RHDELTATHX, opportunistiuc apicomplexan parasite, two splicing variants, a short and a large one
Q4VRV6
SwissProt
Manually annotated by BRENDA team
wild type and mutants
-
-
Manually annotated by BRENDA team
strain Elstree, propagated in Vero cells
-
-
Manually annotated by BRENDA team
Vaccinia virus Elstree
strain Elstree, propagated in Vero cells
-
-
Manually annotated by BRENDA team
Walp., infected with Rhizobium strain CB756
-
-
Manually annotated by BRENDA team
PDB
SCOP
CATH
ORGANISM
Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)
Campylobacter jejuni subsp. jejuni serotype O:2 (strain NCTC 11168)
Cryptosporidium parvum (strain Iowa II)
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
ORGANIC SOLVENT
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
dimethyl sulfoxide
-, Q81W29
up to 15-20% increase IMP dehydrogenase activity
dimethyl sulfoxide
-
up to 15-20% increase IMP dehydrogenase activity
Renatured/COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
by at least 50fold dilution after denaturation with guanidinium hydrochloride, urea, or SDS, overview; readily renatured following denaturation with urea, guanidine-HCl and SDS
-