BRENDA - Enzyme Database show
show all sequences of 1.1.1.205

IMP dehydrogenase: Structure, mechanism, and inhibition

Hedstrom, L.; Chem. Rev. 109, 2903-2928 (2009)

Data extracted from this reference:

Application
Application
Commentary
Organism
drug development
IMPDH2 is the major target for cancer chemotherapy
Homo sapiens
Cloned(Commentary)
Commentary
Organism
-
Borreliella burgdorferi
-
Cricetulus griseus
-
Escherichia coli
-
Pneumocystis carinii
-
Pyrococcus horikoshii
-
Streptococcus pyogenes
-
Toxoplasma gondii
expressed in Escherichia coli
Cryptosporidium parvum
expressed in Escherichia coli
Tritrichomonas suis
expressed in Escherichia coli; expressed in Escherichia coli
Homo sapiens
Crystallization (Commentary)
Crystallization
Organism
tetramer structure of IMPDH shows square planar geometry
Streptococcus pyogenes
Engineering
Amino acid exchange
Commentary
Organism
D226N
IMPDH1 polymorphism, which is associated with retinal degeneration
Homo sapiens
D301N
IMPDH1 polymorphism, which does not affect protein function
Homo sapiens
G324D
IMPDH1 polymorphism, which does not affect protein function
Homo sapiens
G519R
IMPDH1 polymorphism, which does not affect protein function
Homo sapiens
H296R
IMPDH1 polymorphism, which does not affect protein function
Homo sapiens
H372P
IMPDH1 polymorphism, which is associated with retinal degeneration
Homo sapiens
L263F
IMPDH2 polymorphism, which decreases the value of kcat by a factor of 10
Homo sapiens
N198K
IMPDH1 polymorphism, which is associated with retinal degeneration and with Leber congenital amaurosis
Homo sapiens
R105W
IMPDH1 polymorphism, which is associated with retinal degeneration and with Leber congenital amaurosis
Homo sapiens
R224P
IMPDH1 polymorphism, which is associated with retinal degeneration
Homo sapiens
R231P
IMPDH1 polymorphism, which causes autosomal dominant retinitis pigmentosa
Homo sapiens
T116M
IMPDH1 polymorphism, which is associated with retinal degeneration
Homo sapiens
V268I
IMPDH1 polymorphism, which is associated with retinal degeneration
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
(2E)-3-furan-2-yl-N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]prop-2-enamide
;
Homo sapiens
1,4-dimethyl-6-nitro-2H-cyclopenta[d]pyridazine
;
Homo sapiens
1-(benzyloxy)-3-(3-pyridin-4-yl-1H-indol-6-yl)urea
;
Homo sapiens
1-methyl-6-[(5-phenyl-1,3-oxazol-2-yl)amino]-1H-indole-3-carbonitrile
;
Homo sapiens
1H-naphtho[2,3-d]imidazol-2-ylmethyl 4-aminobenzoate
binds in the nicotinamide subsite and does not interact with ADP
Cryptosporidium parvum
2-(1-benzothiophen-3-yl)-6-methoxy-5-(1,3-oxazol-5-yl)-1H-indole-3-carbaldehyde
;
Homo sapiens
2-[(3-ethyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide
antagonizes ADP binding
Cryptosporidium parvum
2-[2-(Z)-fluorovinyl]-inosine 5'-phosphate
is a time-dependent inactivator
Escherichia coli
2-[methyl[2-(2-[[3-(1,3-oxazol-5-yl)-1H-indol-6-yl]amino]-1,3-oxazol-5-yl)phenyl]amino]-2-oxoethyl acetate
;
Homo sapiens
2264A
inhibits lymphocyte proliferation; inhibits lymphocyte proliferation
Homo sapiens
2264B
inhibits lymphocyte proliferation; inhibits lymphocyte proliferation
Homo sapiens
3-hydrogenkwadaphnin
;
Homo sapiens
4-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-6-phenyl-1,3,5-triazin-2-ol
;
Homo sapiens
5-bromoisoquinolin-6-amine
;
Homo sapiens
5-chloro-1,4-dimethyl-2H-cyclopenta[d]pyridazine-6-carbonitrile
;
Homo sapiens
6,6'-oxydi(1,4-dihydroquinoxaline-2,3-dione)
binds in the nicotinamide subsite and does not interact with ADP
Cryptosporidium parvum
6-chloroinosine 5'-phosphate
;
Homo sapiens
6-Cl-IMP
-
Enterobacter aerogenes
7-methoxy-2-(3-methylphenyl)-6-(1,3-oxazol-5-yl)quinolin-4(1H)-one
;
Homo sapiens
7-methoxy-6-(1,3-oxazol-5-yl)-3-(2-pyridin-4-ylethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one
;
Homo sapiens
ADP
-
Cryptosporidium parvum
ADP
;
Homo sapiens
ADP
binds in the adenosine portion, tiazofurin and ADP are strongly synergistic inhibitors, a conformational change occurs upon the binding of one inhibitor that increases the affinity of the second inhibitor
Tritrichomonas suis
AVN944
induces caspase-independent apoptosis in multiple myeloma cell lines and displays antiproliferative activity against both androgen-dependent and androgen-independent prostate cancer cell lines; induces caspase-independent apoptosis in multiple myeloma cell lines and displays antiproliferative activity against both androgen-dependent and androgen-independent prostate cancer cell lines
Homo sapiens
benzamide riboside
displays skeletal muscle toxicity in preclinical trials, which limits its utility; displays skeletal muscle toxicity in preclinical trials, which limits its utility
Homo sapiens
beta-difluoromethylene-tiazofurin
;
Homo sapiens
beta-methylene-tiazofurin
;
Homo sapiens
blastadin 11
;
Homo sapiens
EAD
-
Escherichia coli
EICARMP
-
Escherichia coli
EICARMP
;
Homo sapiens
eicosadienoic acid
competitive inhibitor versus IMPDH; competitive inhibitor versus IMPDH
Homo sapiens
ethyl 9-oxo-9,10-dihydroacridine-1-carboxylate
;
Homo sapiens
FFAD
;
Homo sapiens
halicyclamine A
;
Homo sapiens
helenalin
;
Homo sapiens
imidazo[4,5-e][1,4]diazapine
fat base nucleotide, inosine 5'-phosphate but not NAD+ protects against inhibition
Escherichia coli
imidazo[4,5-e][1,4]diazapine
fat base nucleotide, inosine 5'-phosphate but not NAD+ protects against inhibition; fat base nucleotide, inosine 5'-phosphate but not NAD+ protects against inhibition
Homo sapiens
Li+
-
Borreliella burgdorferi
Li+
-
Escherichia coli
linoleic acid
;
Homo sapiens
merimepodib
has immunosuppressive activity; has immunosuppressive activity
Homo sapiens
methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylate
antagonizes ADP binding
Cryptosporidium parvum
mizoribine
-
Candida albicans
mizoribine
-
Eimeria tenella
mizoribine
-
Escherichia coli
mizoribine
;
Homo sapiens
mizoribine
-
Leishmania donovani
mizoribine
-
Plasmodium falciparum
mizoribine
-
Staphylococcus aureus
mizoribine
-
Tritrichomonas suis
mizoribine
-
Trypanosoma brucei
additional information
IMPDH2 interacts with protein kinase B/Akt via its plekstrin homology domain, the resulting phosphorylation reduces activity
Homo sapiens
additional information
becomes resistant to IMPDH inhibitors by rearranging its purine salvage pathways to rely on xanthine instead of hypoxanthine
Tritrichomonas suis
Mycophenolic acid
-
Candida albicans
Mycophenolic acid
-
Eimeria tenella
Mycophenolic acid
-
Plasmodium falciparum
Mycophenolic acid
-
Staphylococcus aureus
Mycophenolic acid
-
Leishmania donovani
Mycophenolic acid
-
Tritrichomonas suis
Mycophenolic acid
;
Homo sapiens
Mycophenolic acid
-
Trypanosoma brucei
N-(4-chlorophenyl)-2-phenoxypropanamide
antagonizes ADP binding
Cryptosporidium parvum
N-(4-methoxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
binds in the nicotinamide subsite and does not interact with ADP
Cryptosporidium parvum
N-(4-methoxyphenyl)-2-naphthalen-1-ylacetamide
binds in the nicotinamide subsite and does not interact with ADP
Cryptosporidium parvum
N-(4-methoxyphenyl)-2-[2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetamide
binds in the nicotinamide subsite and does not interact with ADP
Cryptosporidium parvum
N-(5-phenyl-1,3-oxazol-2-yl)isoquinolin-6-amine
;
Homo sapiens
N-[(Z)-(pyridin-3-ylimino)methyl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide
-
Cryptosporidium parvum
N-[1-[6-(4-ethylpiperazin-1-yl)pyridin-3-yl]-1-methylethyl]-2-fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide
;
Homo sapiens
N-[2-(2-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-2-morpholin-4-ylacetamide
;
Homo sapiens
N-[2-(hydroxymethyl)cyclopentyl]-N'-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]propanediamide
;
Homo sapiens
Na+
-
Borreliella burgdorferi
Na+
-
Escherichia coli
pellynic acid
;
Homo sapiens
phenyl N'-cyano-N-(3-[cyano[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamimidamido]benzyl)imidocarbamate
;
Homo sapiens
ribavirin
;
Homo sapiens
ribavirin
-
Tritrichomonas suis
Selenazofurin
;
Homo sapiens
SFAD
;
Homo sapiens
tert-butyl methyl (1S,4S)-7'-methoxy-3'-methyl-6'-(1,3-oxazol-5-yl)-4'-oxo-3',4'-dihydro-1'H-spiro[cyclopentane-1,2'-quinazoline]-3,4-dicarboxylate
;
Homo sapiens
TFAD
;
Homo sapiens
tiazofurin
-
Cryptosporidium parvum
tiazofurin
binds in the nicotinamide portion of the dinucleotide site, tiazofurin and ADP are strongly synergistic inhibitors, a conformational change occurs upon the binding of one inhibitor that increases the affinity of the second inhibitor
Tritrichomonas suis
tiazofurin
;
Homo sapiens
VX-148
has immunosuppressive activity; has immunosuppressive activity
Homo sapiens
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Cs+
activates
Borreliella burgdorferi
Cs+
activates
Escherichia coli
K+
activates
Borreliella burgdorferi
K+
activates
Escherichia coli
K+
activates
Homo sapiens
K+
-
Streptococcus pyogenes
K+
activates
Tritrichomonas suis
additional information
Na+ has no effect on activity
Cryptosporidium parvum
additional information
Li+ has no effect on activity of IMPDH2
Homo sapiens
Na+
activates
Homo sapiens
Na+
activates
Tritrichomonas suis
NH4+
activates
Borreliella burgdorferi
NH4+
activates
Escherichia coli
NH4+
activates
Homo sapiens
Rb+
activates
Homo sapiens
Tl+
activates
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Borreliella burgdorferi
P49058
-
-
Candida albicans
-
-
-
Cricetulus griseus
-
Chinese hamster type 2
-
Cryptosporidium parvum
Q8T6T2
-
-
Eimeria tenella
-
-
-
Enterobacter aerogenes
-
-
-
Escherichia coli
-
-
-
Homo sapiens
P12268
-
-
Homo sapiens
P20839
-
-
Leishmania donovani
P21620
-
-
no activity in Giardia lamblia
-
-
-
no activity in Trichomonas vaginalis
-
-
-
Plasmodium falciparum
-
-
-
Pneumocystis carinii
Q12658
-
-
Pyrococcus horikoshii
-
-
-
Staphylococcus aureus
-
-
-
Streptococcus pyogenes
P0C0H6
-
-
Toxoplasma gondii
-
-
-
Tritrichomonas suis
P50097
-
-
Trypanosoma brucei
P50098
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
myeloma cell
;
Homo sapiens
-
peripheral blood mononuclear cell
;
Homo sapiens
-
prostate cancer cell
;
Homo sapiens
-
retina
; IMPDH1 predominates in the adult retina
Homo sapiens
-
spleen
;
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
inosine 5'-phosphate + NAD+ + H2O
-
703193
Cricetulus griseus
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Staphylococcus aureus
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Escherichia coli
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Enterobacter aerogenes
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Candida albicans
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Plasmodium falciparum
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Eimeria tenella
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Pyrococcus horikoshii
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Homo sapiens
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Tritrichomonas suis
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Cryptosporidium parvum
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Leishmania donovani
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Trypanosoma brucei
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Streptococcus pyogenes
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Pneumocystis carinii
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Borreliella burgdorferi
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
additional information
the CBS subdomain of IMPDH coordinately regulates the adenine and guanine nucleotide pool
703193
Escherichia coli
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
tetramer
crystallography
Streptococcus pyogenes
Cofactor
Cofactor
Commentary
Organism
Structure
NAD+
-
Borreliella burgdorferi
NAD+
-
Candida albicans
NAD+
-
Cricetulus griseus
NAD+
-
Eimeria tenella
NAD+
-
Enterobacter aerogenes
NAD+
;
Homo sapiens
NAD+
-
Leishmania donovani
NAD+
-
Plasmodium falciparum
NAD+
-
Pneumocystis carinii
NAD+
-
Pyrococcus horikoshii
NAD+
-
Staphylococcus aureus
NAD+
-
Streptococcus pyogenes
NAD+
-
Tritrichomonas suis
NAD+
-
Escherichia coli
NAD+
-
Cryptosporidium parvum
NAD+
-
Trypanosoma brucei
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.0000005
-
mizoribine
-
Escherichia coli
0.000001
-
imidazo[4,5-e][1,4]diazapine
-
Homo sapiens
0.000006
-
AVN944
;
Homo sapiens
0.000006
-
VX-148
-
Homo sapiens
0.000007
-
merimepodib
;
Homo sapiens
0.000008
-
mizoribine
-
Homo sapiens
0.000014
-
VX-148
-
Homo sapiens
0.00002
-
Selenazofurin
with inosine 5'-phosphate as substrate
Homo sapiens
0.00003
-
Selenazofurin
with inosine 5'-phosphate as substrate
Homo sapiens
0.00005
-
imidazo[4,5-e][1,4]diazapine
IMPDH2
Escherichia coli
0.00043
-
TFAD
with inosine 5'-phosphate as substrate
Homo sapiens
0.00043
-
tiazofurin
with inosine 5'-phosphate as substrate
Homo sapiens
0.00058
-
SFAD
with inosine 5'-phosphate as substrate
Homo sapiens
0.0007
-
TFAD
with inosine 5'-phosphate as substrate
Homo sapiens
0.0007
-
tiazofurin
with inosine 5'-phosphate as substrate
Homo sapiens
0.001
-
2-[2-(Z)-fluorovinyl]-inosine 5'-phosphate
-
Escherichia coli
0.0011
-
SFAD
with inosine 5'-phosphate as substrate
Homo sapiens
0.002
-
EICARMP
-
Escherichia coli
0.003
-
eicosadienoic acid
-
Homo sapiens
0.016
-
EICARMP
-
Homo sapiens
0.027
-
EAD
-
Escherichia coli
0.038
-
FFAD
with inosine 5'-phosphate as substrate
Homo sapiens
0.056
-
FFAD
with inosine 5'-phosphate as substrate
Homo sapiens
0.078
-
6-chloroinosine 5'-phosphate
-
Homo sapiens
0.26
-
6-Cl-IMP
-
Enterobacter aerogenes
1.3
-
tiazofurin
;
Homo sapiens
1.5
-
tiazofurin
-
Cryptosporidium parvum
8.8
-
ADP
;
Homo sapiens
31
-
ADP
-
Tritrichomonas suis
42
-
ADP
-
Cryptosporidium parvum
50
-
tiazofurin
-
Tritrichomonas suis
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.000005
-
-
Homo sapiens
7-methoxy-2-(3-methylphenyl)-6-(1,3-oxazol-5-yl)quinolin-4(1H)-one
0.000005
-
-
Homo sapiens
N-(5-phenyl-1,3-oxazol-2-yl)isoquinolin-6-amine
0.000007
-
-
Homo sapiens
2-[methyl[2-(2-[[3-(1,3-oxazol-5-yl)-1H-indol-6-yl]amino]-1,3-oxazol-5-yl)phenyl]amino]-2-oxoethyl acetate
0.000012
-
-
Homo sapiens
N-[2-(2-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-2-morpholin-4-ylacetamide
0.000013
-
-
Homo sapiens
7-methoxy-6-(1,3-oxazol-5-yl)-3-(2-pyridin-4-ylethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one
0.000016
-
-
Homo sapiens
phenyl N'-cyano-N-(3-[cyano[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamimidamido]benzyl)imidocarbamate
0.000017
-
-
Homo sapiens
N-[1-[6-(4-ethylpiperazin-1-yl)pyridin-3-yl]-1-methylethyl]-2-fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide
0.000018
-
-
Homo sapiens
4-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-6-phenyl-1,3,5-triazin-2-ol
0.000018
-
-
Homo sapiens
N-[2-(hydroxymethyl)cyclopentyl]-N'-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]propanediamide
0.000028
-
-
Homo sapiens
(2E)-3-furan-2-yl-N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]prop-2-enamide
0.00003
-
-
Homo sapiens
2-(1-benzothiophen-3-yl)-6-methoxy-5-(1,3-oxazol-5-yl)-1H-indole-3-carbaldehyde
0.000033
-
-
Homo sapiens
1-methyl-6-[(5-phenyl-1,3-oxazol-2-yl)amino]-1H-indole-3-carbonitrile
0.000035
-
-
Homo sapiens
tert-butyl methyl (1S,4S)-7'-methoxy-3'-methyl-6'-(1,3-oxazol-5-yl)-4'-oxo-3',4'-dihydro-1'H-spiro[cyclopentane-1,2'-quinazoline]-3,4-dicarboxylate
0.000076
-
-
Homo sapiens
1-(benzyloxy)-3-(3-pyridin-4-yl-1H-indol-6-yl)urea
0.0005
-
-
Homo sapiens
5-bromoisoquinolin-6-amine
0.00073
-
-
Homo sapiens
ethyl 9-oxo-9,10-dihydroacridine-1-carboxylate
0.00076
-
-
Homo sapiens
5-chloro-1,4-dimethyl-2H-cyclopenta[d]pyridazine-6-carbonitrile
0.001
-
-
Homo sapiens
pellynic acid
0.0019
-
-
Homo sapiens
1,4-dimethyl-6-nitro-2H-cyclopenta[d]pyridazine
0.07
-
-
Homo sapiens
2264A
Application (protein specific)
Application
Commentary
Organism
drug development
IMPDH2 is the major target for cancer chemotherapy
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
-
Borreliella burgdorferi
-
Cricetulus griseus
-
Escherichia coli
-
Pneumocystis carinii
-
Pyrococcus horikoshii
-
Streptococcus pyogenes
-
Toxoplasma gondii
expressed in Escherichia coli
Cryptosporidium parvum
expressed in Escherichia coli
Homo sapiens
expressed in Escherichia coli
Tritrichomonas suis
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NAD+
-
Borreliella burgdorferi
NAD+
-
Candida albicans
NAD+
-
Cricetulus griseus
NAD+
-
Eimeria tenella
NAD+
-
Enterobacter aerogenes
NAD+
-
Homo sapiens
NAD+
-
Leishmania donovani
NAD+
-
Plasmodium falciparum
NAD+
-
Pneumocystis carinii
NAD+
-
Pyrococcus horikoshii
NAD+
-
Staphylococcus aureus
NAD+
-
Streptococcus pyogenes
NAD+
-
Tritrichomonas suis
NAD+
-
Trypanosoma brucei
NAD+
-
Escherichia coli
NAD+
-
Cryptosporidium parvum
Crystallization (Commentary) (protein specific)
Crystallization
Organism
tetramer structure of IMPDH shows square planar geometry
Streptococcus pyogenes
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
D226N
IMPDH1 polymorphism, which is associated with retinal degeneration
Homo sapiens
D301N
IMPDH1 polymorphism, which does not affect protein function
Homo sapiens
G324D
IMPDH1 polymorphism, which does not affect protein function
Homo sapiens
G519R
IMPDH1 polymorphism, which does not affect protein function
Homo sapiens
H296R
IMPDH1 polymorphism, which does not affect protein function
Homo sapiens
H372P
IMPDH1 polymorphism, which is associated with retinal degeneration
Homo sapiens
L263F
IMPDH2 polymorphism, which decreases the value of kcat by a factor of 10
Homo sapiens
N198K
IMPDH1 polymorphism, which is associated with retinal degeneration and with Leber congenital amaurosis
Homo sapiens
R105W
IMPDH1 polymorphism, which is associated with retinal degeneration and with Leber congenital amaurosis
Homo sapiens
R224P
IMPDH1 polymorphism, which is associated with retinal degeneration
Homo sapiens
R231P
IMPDH1 polymorphism, which causes autosomal dominant retinitis pigmentosa
Homo sapiens
T116M
IMPDH1 polymorphism, which is associated with retinal degeneration
Homo sapiens
V268I
IMPDH1 polymorphism, which is associated with retinal degeneration
Homo sapiens
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.000005
-
-
Homo sapiens
7-methoxy-2-(3-methylphenyl)-6-(1,3-oxazol-5-yl)quinolin-4(1H)-one
0.000005
-
-
Homo sapiens
N-(5-phenyl-1,3-oxazol-2-yl)isoquinolin-6-amine
0.000007
-
-
Homo sapiens
2-[methyl[2-(2-[[3-(1,3-oxazol-5-yl)-1H-indol-6-yl]amino]-1,3-oxazol-5-yl)phenyl]amino]-2-oxoethyl acetate
0.000012
-
-
Homo sapiens
N-[2-(2-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-2-morpholin-4-ylacetamide
0.000013
-
-
Homo sapiens
7-methoxy-6-(1,3-oxazol-5-yl)-3-(2-pyridin-4-ylethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one
0.000016
-
-
Homo sapiens
phenyl N'-cyano-N-(3-[cyano[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamimidamido]benzyl)imidocarbamate
0.000017
-
-
Homo sapiens
N-[1-[6-(4-ethylpiperazin-1-yl)pyridin-3-yl]-1-methylethyl]-2-fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide
0.000018
-
-
Homo sapiens
4-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-6-phenyl-1,3,5-triazin-2-ol
0.000018
-
-
Homo sapiens
N-[2-(hydroxymethyl)cyclopentyl]-N'-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]propanediamide
0.000028
-
-
Homo sapiens
(2E)-3-furan-2-yl-N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]prop-2-enamide
0.00003
-
-
Homo sapiens
2-(1-benzothiophen-3-yl)-6-methoxy-5-(1,3-oxazol-5-yl)-1H-indole-3-carbaldehyde
0.000033
-
-
Homo sapiens
1-methyl-6-[(5-phenyl-1,3-oxazol-2-yl)amino]-1H-indole-3-carbonitrile
0.000035
-
-
Homo sapiens
tert-butyl methyl (1S,4S)-7'-methoxy-3'-methyl-6'-(1,3-oxazol-5-yl)-4'-oxo-3',4'-dihydro-1'H-spiro[cyclopentane-1,2'-quinazoline]-3,4-dicarboxylate
0.000076
-
-
Homo sapiens
1-(benzyloxy)-3-(3-pyridin-4-yl-1H-indol-6-yl)urea
0.0005
-
-
Homo sapiens
5-bromoisoquinolin-6-amine
0.00073
-
-
Homo sapiens
ethyl 9-oxo-9,10-dihydroacridine-1-carboxylate
0.00076
-
-
Homo sapiens
5-chloro-1,4-dimethyl-2H-cyclopenta[d]pyridazine-6-carbonitrile
0.001
-
-
Homo sapiens
pellynic acid
0.0019
-
-
Homo sapiens
1,4-dimethyl-6-nitro-2H-cyclopenta[d]pyridazine
0.07
-
-
Homo sapiens
2264A
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
(2E)-3-furan-2-yl-N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]prop-2-enamide
-
Homo sapiens
1,4-dimethyl-6-nitro-2H-cyclopenta[d]pyridazine
-
Homo sapiens
1-(benzyloxy)-3-(3-pyridin-4-yl-1H-indol-6-yl)urea
-
Homo sapiens
1-methyl-6-[(5-phenyl-1,3-oxazol-2-yl)amino]-1H-indole-3-carbonitrile
-
Homo sapiens
1H-naphtho[2,3-d]imidazol-2-ylmethyl 4-aminobenzoate
binds in the nicotinamide subsite and does not interact with ADP
Cryptosporidium parvum
2-(1-benzothiophen-3-yl)-6-methoxy-5-(1,3-oxazol-5-yl)-1H-indole-3-carbaldehyde
-
Homo sapiens
2-[(3-ethyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide
antagonizes ADP binding
Cryptosporidium parvum
2-[2-(Z)-fluorovinyl]-inosine 5'-phosphate
is a time-dependent inactivator
Escherichia coli
2-[methyl[2-(2-[[3-(1,3-oxazol-5-yl)-1H-indol-6-yl]amino]-1,3-oxazol-5-yl)phenyl]amino]-2-oxoethyl acetate
-
Homo sapiens
2264A
inhibits lymphocyte proliferation
Homo sapiens
2264B
inhibits lymphocyte proliferation
Homo sapiens
3-hydrogenkwadaphnin
-
Homo sapiens
4-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-6-phenyl-1,3,5-triazin-2-ol
-
Homo sapiens
5-bromoisoquinolin-6-amine
-
Homo sapiens
5-chloro-1,4-dimethyl-2H-cyclopenta[d]pyridazine-6-carbonitrile
-
Homo sapiens
6,6'-oxydi(1,4-dihydroquinoxaline-2,3-dione)
binds in the nicotinamide subsite and does not interact with ADP
Cryptosporidium parvum
6-chloroinosine 5'-phosphate
-
Homo sapiens
6-Cl-IMP
-
Enterobacter aerogenes
7-methoxy-2-(3-methylphenyl)-6-(1,3-oxazol-5-yl)quinolin-4(1H)-one
-
Homo sapiens
7-methoxy-6-(1,3-oxazol-5-yl)-3-(2-pyridin-4-ylethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one
-
Homo sapiens
ADP
-
Cryptosporidium parvum
ADP
-
Homo sapiens
ADP
binds in the adenosine portion, tiazofurin and ADP are strongly synergistic inhibitors, a conformational change occurs upon the binding of one inhibitor that increases the affinity of the second inhibitor
Tritrichomonas suis
AVN944
induces caspase-independent apoptosis in multiple myeloma cell lines and displays antiproliferative activity against both androgen-dependent and androgen-independent prostate cancer cell lines
Homo sapiens
benzamide riboside
displays skeletal muscle toxicity in preclinical trials, which limits its utility
Homo sapiens
beta-difluoromethylene-tiazofurin
-
Homo sapiens
beta-methylene-tiazofurin
-
Homo sapiens
blastadin 11
-
Homo sapiens
EAD
-
Escherichia coli
EICARMP
-
Escherichia coli
EICARMP
-
Homo sapiens
eicosadienoic acid
competitive inhibitor versus IMPDH
Homo sapiens
ethyl 9-oxo-9,10-dihydroacridine-1-carboxylate
-
Homo sapiens
FFAD
-
Homo sapiens
halicyclamine A
-
Homo sapiens
helenalin
-
Homo sapiens
imidazo[4,5-e][1,4]diazapine
fat base nucleotide, inosine 5'-phosphate but not NAD+ protects against inhibition
Escherichia coli
imidazo[4,5-e][1,4]diazapine
fat base nucleotide, inosine 5'-phosphate but not NAD+ protects against inhibition
Homo sapiens
Li+
-
Borreliella burgdorferi
Li+
-
Escherichia coli
linoleic acid
-
Homo sapiens
merimepodib
has immunosuppressive activity
Homo sapiens
methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylate
antagonizes ADP binding
Cryptosporidium parvum
mizoribine
-
Candida albicans
mizoribine
-
Eimeria tenella
mizoribine
-
Escherichia coli
mizoribine
-
Homo sapiens
mizoribine
-
Leishmania donovani
mizoribine
-
Plasmodium falciparum
mizoribine
-
Staphylococcus aureus
mizoribine
-
Tritrichomonas suis
mizoribine
-
Trypanosoma brucei
additional information
IMPDH2 interacts with protein kinase B/Akt via its plekstrin homology domain, the resulting phosphorylation reduces activity
Homo sapiens
additional information
becomes resistant to IMPDH inhibitors by rearranging its purine salvage pathways to rely on xanthine instead of hypoxanthine
Tritrichomonas suis
Mycophenolic acid
-
Candida albicans
Mycophenolic acid
-
Eimeria tenella
Mycophenolic acid
-
Leishmania donovani
Mycophenolic acid
-
Plasmodium falciparum
Mycophenolic acid
-
Staphylococcus aureus
Mycophenolic acid
-
Tritrichomonas suis
Mycophenolic acid
-
Trypanosoma brucei
Mycophenolic acid
-
Homo sapiens
N-(4-chlorophenyl)-2-phenoxypropanamide
antagonizes ADP binding
Cryptosporidium parvum
N-(4-methoxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
binds in the nicotinamide subsite and does not interact with ADP
Cryptosporidium parvum
N-(4-methoxyphenyl)-2-naphthalen-1-ylacetamide
binds in the nicotinamide subsite and does not interact with ADP
Cryptosporidium parvum
N-(4-methoxyphenyl)-2-[2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetamide
binds in the nicotinamide subsite and does not interact with ADP
Cryptosporidium parvum
N-(5-phenyl-1,3-oxazol-2-yl)isoquinolin-6-amine
-
Homo sapiens
N-[(Z)-(pyridin-3-ylimino)methyl]-2,3-dihydro-1,4-benzodioxine-2-carboxamide
-
Cryptosporidium parvum
N-[1-[6-(4-ethylpiperazin-1-yl)pyridin-3-yl]-1-methylethyl]-2-fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide
-
Homo sapiens
N-[2-(2-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-2-morpholin-4-ylacetamide
-
Homo sapiens
N-[2-(hydroxymethyl)cyclopentyl]-N'-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]propanediamide
-
Homo sapiens
Na+
-
Borreliella burgdorferi
Na+
-
Escherichia coli
pellynic acid
-
Homo sapiens
phenyl N'-cyano-N-(3-[cyano[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamimidamido]benzyl)imidocarbamate
-
Homo sapiens
ribavirin
-
Homo sapiens
ribavirin
-
Tritrichomonas suis
Selenazofurin
-
Homo sapiens
SFAD
-
Homo sapiens
tert-butyl methyl (1S,4S)-7'-methoxy-3'-methyl-6'-(1,3-oxazol-5-yl)-4'-oxo-3',4'-dihydro-1'H-spiro[cyclopentane-1,2'-quinazoline]-3,4-dicarboxylate
-
Homo sapiens
TFAD
-
Homo sapiens
tiazofurin
-
Cryptosporidium parvum
tiazofurin
binds in the nicotinamide portion of the dinucleotide site, tiazofurin and ADP are strongly synergistic inhibitors, a conformational change occurs upon the binding of one inhibitor that increases the affinity of the second inhibitor
Tritrichomonas suis
tiazofurin
-
Homo sapiens
VX-148
has immunosuppressive activity
Homo sapiens
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.0000005
-
mizoribine
-
Escherichia coli
0.000001
-
imidazo[4,5-e][1,4]diazapine
-
Homo sapiens
0.000006
-
AVN944
-
Homo sapiens
0.000006
-
VX-148
-
Homo sapiens
0.000007
-
merimepodib
-
Homo sapiens
0.000008
-
mizoribine
-
Homo sapiens
0.000014
-
VX-148
-
Homo sapiens
0.00002
-
Selenazofurin
with inosine 5'-phosphate as substrate
Homo sapiens
0.00003
-
Selenazofurin
with inosine 5'-phosphate as substrate
Homo sapiens
0.00005
-
imidazo[4,5-e][1,4]diazapine
IMPDH2
Escherichia coli
0.00043
-
TFAD
with inosine 5'-phosphate as substrate
Homo sapiens
0.00043
-
tiazofurin
with inosine 5'-phosphate as substrate
Homo sapiens
0.00058
-
SFAD
with inosine 5'-phosphate as substrate
Homo sapiens
0.0007
-
TFAD
with inosine 5'-phosphate as substrate
Homo sapiens
0.0007
-
tiazofurin
with inosine 5'-phosphate as substrate
Homo sapiens
0.001
-
2-[2-(Z)-fluorovinyl]-inosine 5'-phosphate
-
Escherichia coli
0.0011
-
SFAD
with inosine 5'-phosphate as substrate
Homo sapiens
0.002
-
EICARMP
-
Escherichia coli
0.003
-
eicosadienoic acid
-
Homo sapiens
0.016
-
EICARMP
-
Homo sapiens
0.027
-
EAD
-
Escherichia coli
0.038
-
FFAD
with inosine 5'-phosphate as substrate
Homo sapiens
0.056
-
FFAD
with inosine 5'-phosphate as substrate
Homo sapiens
0.078
-
6-chloroinosine 5'-phosphate
-
Homo sapiens
0.26
-
6-Cl-IMP
-
Enterobacter aerogenes
1.3
-
tiazofurin
-
Homo sapiens
1.5
-
tiazofurin
-
Cryptosporidium parvum
8.8
-
ADP
-
Homo sapiens
31
-
ADP
-
Tritrichomonas suis
42
-
ADP
-
Cryptosporidium parvum
50
-
tiazofurin
-
Tritrichomonas suis
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Cs+
activates
Borreliella burgdorferi
Cs+
activates
Escherichia coli
K+
activates
Borreliella burgdorferi
K+
activates
Escherichia coli
K+
activates
Homo sapiens
K+
-
Streptococcus pyogenes
K+
activates
Tritrichomonas suis
additional information
Na+ has no effect on activity
Cryptosporidium parvum
additional information
Li+ has no effect on activity of IMPDH2
Homo sapiens
Na+
activates
Homo sapiens
Na+
activates
Tritrichomonas suis
NH4+
activates
Borreliella burgdorferi
NH4+
activates
Escherichia coli
NH4+
activates
Homo sapiens
Rb+
activates
Homo sapiens
Tl+
activates
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
myeloma cell
-
Homo sapiens
-
peripheral blood mononuclear cell
-
Homo sapiens
-
prostate cancer cell
-
Homo sapiens
-
retina
IMPDH1 predominates in the adult retina
Homo sapiens
-
retina
-
Homo sapiens
-
spleen
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
inosine 5'-phosphate + NAD+ + H2O
-
703193
Cricetulus griseus
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Staphylococcus aureus
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Escherichia coli
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Enterobacter aerogenes
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Candida albicans
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Plasmodium falciparum
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Eimeria tenella
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Pyrococcus horikoshii
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Homo sapiens
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Tritrichomonas suis
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Cryptosporidium parvum
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Leishmania donovani
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Trypanosoma brucei
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Streptococcus pyogenes
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Pneumocystis carinii
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
inosine 5'-phosphate + NAD+ + H2O
-
703193
Borreliella burgdorferi
xanthosine 5'-phosphate + NADH + H+
-
-
-
?
additional information
the CBS subdomain of IMPDH coordinately regulates the adenine and guanine nucleotide pool
703193
Escherichia coli
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
tetramer
crystallography
Streptococcus pyogenes
General Information
General Information
Commentary
Organism
physiological function
mutations in the CBS subdomain of IMPDH1 account for 2-3% of autosomal dominant retinitis pigmentosa
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
physiological function
mutations in the CBS subdomain of IMPDH1 account for 2-3% of autosomal dominant retinitis pigmentosa
Homo sapiens
Other publictions for EC 1.1.1.205
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
723875
Rao
Structure of Pseudomonas aerug ...
Pseudomonas aeruginosa
Acta Crystallogr. Sect. F
69
243-247
2013
-
-
-
1
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
724539
Johnson
Phthalazinone inhibitors of in ...
Cryptosporidium parvum
Bioorg. Med. Chem. Lett.
23
1004-1007
2013
-
-
-
-
-
-
1
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
725678
Gorla
Optimization of benzoxazole-ba ...
Cryptosporidium parvum
J. Med. Chem.
56
4028-4043
2013
-
-
1
-
-
-
3
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
1
-
-
-
-
3
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
726095
Cao
Cloning, characterization and ...
Babesia gibsoni
Parasitol. Int.
62
87-94
2013
-
-
1
-
-
-
1
2
-
-
1
1
-
5
-
-
-
-
-
-
-
-
1
1
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
1
2
-
-
1
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
726097
Bessho
Characterization of the novel ...
Trypanosoma brucei
Parasitology
140
735-745
2013
-
-
1
-
-
-
4
2
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3
1
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4
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1
1
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1
1
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1
4
-
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1
1
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4
4
2
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3
1
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1
1
-
-
-
1
1
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724347
Makowska-Grzyska
Bacillus anthracis inosine 5-m ...
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Biochemistry
51
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2012
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1
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7
2
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2
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1
1
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4
-
4
7
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2
1
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4
7
4
2
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2
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2
-
-
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1
1
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725673
Gorla
Selective and potent urea inhi ...
Cryptosporidium parvum
J. Med. Chem.
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7759-7771
2012
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3
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3
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3
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726311
Thomas
Different characteristics and ...
Homo sapiens
PLoS ONE
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2012
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-
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-
-
-
-
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1
2
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711475
Felczak
Cofactor-type inhibitors of in ...
Homo sapiens
Bioorg. Med. Chem.
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1594-1605
2011
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9
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15
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16
16
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724327
Riera
Allosteric activation via kine ...
Cryptosporidium parvum
Biochemistry
50
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2011
1
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1
5
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2
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5
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2
3
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1
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2
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1
3
5
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-
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-
-
-
2
-
-
-
-
5
-
-
-
-
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-
-
-
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-
724668
Hansen
A new class of IMP dehydrogena ...
Penicillium brevicompactum
BMC Microbiol.
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202
2011
-
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4
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-
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-
-
-
-
-
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1
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706090
Winnicki
An inosine 5-monophosphate deh ...
Homo sapiens
Pharmacogenomics J.
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70-76
2010
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1
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1
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1
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1
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1
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-
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1
1
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710737
Morrow
Crystallization and preliminar ...
Cryptococcus gattii VGIII, Cryptococcus neoformans, Cryptococcus neoformans H99
Acta Crystallogr. Sect. F
66
1104-1107
2010
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2
2
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2
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2
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2
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2
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2
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2
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2
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2
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2
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-
-
-
-
2
-
-
-
-
-
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-
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-
-
-
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711087
Park
IMP dehydrogenase is recruited ...
Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
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588-592
2010
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1
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-
-
-
-
-
-
-
-
-
-
-
-
1
1
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711219
Josephine
The Cys319 loop modulates the ...
Tritrichomonas suis
Biochemistry
49
10674-10681
2010
-
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1
4
-
2
10
-
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2
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1
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5
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10
-
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1
4
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-
2
10
10
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-
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-
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-
1
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-
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-
5
-
-
-
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-
-
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711473
Mitsuhashi
Structure-activity relationshi ...
Homo sapiens
Bioorg. Med. Chem.
18
8106-8111
2010
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1
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6
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9
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2
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10
12
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-
-
-
-
-
-
-
-
-
-
-
-
-
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711518
Dairaku
Inhibitory effect of curcumin ...
Homo sapiens, Mus musculus
Biosci. Biotechnol. Biochem.
74
185-187
2010
-
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2
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-
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6
1
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-
-
2
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1
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-
1
-
-
-
-
-
-
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-
-
1
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-
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-
2
-
-
-
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6
1
1
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-
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1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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711735
Gollapalli
Structural determinants of inh ...
Borreliella burgdorferi, Escherichia coli, Helicobacter pylori, Streptococcus pyogenes
Chem. Biol.
17
1084-1091
2010
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1
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12
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1
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27
29
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-
-
-
-
-
-
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712245
Macpherson
The structural basis of Crypto ...
Cryptosporidium parvum
J. Am. Chem. Soc.
132
1230-1231
2010
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1
1
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4
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1
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4
-
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1
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1
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4
4
-
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
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712578
Maiguma
Evaluation of inosin-5-monopho ...
Homo sapiens
J. Clin. Pharm. Ther.
35
79-85
2010
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1
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1
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1
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-
-
-
-
-
-
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-
-
-
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712703
Chen
Triazole-linked inhibitors of ...
Homo sapiens, Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Med. Chem.
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2010
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1
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6
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1
3
3
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10
6
2
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4
-
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1
-
-
-
-
-
-
-
-
-
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701583
Pimkin
Inosine 5-monophosphate dehydr ...
Borreliella burgdorferi, Candida albicans, Cricetulus griseus, Cryptosporidium parvum, Enterobacter aerogenes, Escherichia coli, Homo sapiens, Mus musculus, Saccharomyces cerevisiae, Streptococcus pyogenes, Tritrichomonas suis
Adv. Enzymol. Relat. Areas Mol. Biol.
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1
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7
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9
22
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1
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9
5
19
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34
22
14
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10
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-
-
-
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-
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-
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9
1
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-
-
7
-
-
-
-
1
1
1
1
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702061
Su
Inhibition of inosine monophos ...
Mus musculus
Biochem. Biophys. Res. Commun.
386
351-355
2009
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1
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-
-
-
2
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2
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3
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-
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1
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-
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2
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-
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3
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-
-
-
-
-
-
-
-
-
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1
1
1
1
-
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703193
Hedstrom
IMP dehydrogenase: Structure, ...
Borreliella burgdorferi, Candida albicans, Cricetulus griseus, Cryptosporidium parvum, Eimeria tenella, Enterobacter aerogenes, Escherichia coli, Homo sapiens, Leishmania donovani, no activity in Giardia lamblia, no activity in Trichomonas vaginalis, Plasmodium falciparum, Pneumocystis carinii, Pyrococcus horikoshii, Staphylococcus aureus, Streptococcus pyogenes, Toxoplasma gondii, Tritrichomonas suis, Trypanosoma brucei
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2009
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1
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31
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20
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1
11
17
1
13
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20
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35
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16
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-
-
-
-
-
10
-
-
18
1
-
-
-
-
-
-
-
-
-
1
1
-
-
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703271
Gensburger
Effect of mycophenolate acyl-g ...
Homo sapiens
Clin. Chem.
55
986-993
2009
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1
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-
-
-
3
2
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2
-
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1
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-
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1
4
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1
-
1
-
-
-
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3
4
2
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
703272
Mino
Inosine monophosphate dehydrog ...
Homo sapiens
Clin. Chim. Acta
409
56-61
2009
1
1
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-
-
-
1
-
-
-
-
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1
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-
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-
1
-
-
-
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-
-
-
-
-
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-
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-
-
-
1
1
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-
-
-
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-
1
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-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
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-
1
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704629
Pimkin
A regulatory role of the Batem ...
Escherichia coli
J. Biol. Chem.
284
7960-7969
2009
-
-
-
-
2
-
-
-
-
-
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2
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-
-
-
-
-
-
-
1
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-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
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704732
Bairagya
An insight to the dynamics of ...
Homo sapiens
J. Biomol. Struct. Dyn.
27
149-158
2009
-
-
-
-
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-
1
-
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-
-
-
2
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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705042
Maurya
Triazole inhibitors of Cryptos ...
Cryptosporidium parvum
J. Med. Chem.
52
4623-4630
2009
-
1
-
-
-
-
1
-
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-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
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1
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-
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-
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-
1
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
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705540
Zhang
Identification and characteriz ...
Streptococcus suis, Streptococcus suis 2
Microb. Pathog.
7
267-273
2009
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1
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1
-
-
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1
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8
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1
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1
2
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1
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1
1
-
1
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-
-
-
1
-
-
-
-
1
-
-
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
706817
Glander
Improved assay for the nonradi ...
Homo sapiens
Ther. Drug Monit.
31
351-359
2009
-
1
-
-
-
-
3
-
-
-
-
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2
-
-
-
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-
1
-
-
1
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-
-
-
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1
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-
1
-
1
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-
-
-
3
-
-
-
-
-
-
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-
-
-
1
-
-
1
-
-
-
-
-
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-
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684706
Xu
Retinal isoforms of inosine 5- ...
Homo sapiens
Arch. Biochem. Biophys.
472
100-104
2008
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1
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9
1
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1
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-
1
1
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4
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-
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1
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1
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2
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9
1
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-
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1
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1
1
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-
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4
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-
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-
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685555
Chen
Bis(sulfonamide) isosters of m ...
Homo sapiens
Bioorg. Med. Chem.
16
7462-7469
2008
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8
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8
16
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-
-
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-
-
-
-
-
-
-
-
-
-
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-
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685852
Haglund
IMPDH activity in thiopurine-t ...
Homo sapiens
Br. J. Clin. Pharmacol.
65
69-77
2008
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1
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-
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1
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-
-
-
-
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-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686191
Sanquer
Expression of inosine monophos ...
Homo sapiens
Clin. Pharmacol. Ther.
83
328-335
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687120
Gunter
Characterisation of inosine mo ...
Rattus norvegicus
Int. J. Biochem. Cell Biol.
40
1716-1728
2008
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689055
Pimkin
The CBS subdomain of inosine 5 ...
Escherichia coli
Mol. Microbiol.
68
342-359
2008
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
690165
Bremer
Expression of IMPDH1 and IMPDH ...
Homo sapiens
Transplantation
85
55-61
2008
-
1
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702243
Riera
A kinetic alignment of ortholo ...
Cryptosporidium parvum, Homo sapiens
Biochemistry
47
8689-8696
2008
-
-
1
-
-
-
-
3
-
-
-
-
-
5
-
-
1
-
-
-
-
-
4
-
-
-
-
3
-
-
-
3
-
-
-
-
-
1
3
-
-
-
-
-
-
3
-
-
-
-
-
-
-
1
-
-
-
-
4
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
705494
Shu
Inosine monophosphate dehydrog ...
Borreliella burgdorferi, Cricetulus griseus, Escherichia coli, Homo sapiens, Leishmania donovani, Mus musculus, Mycobacterium tuberculosis, Pyrococcus horikoshii OT3, Rattus norvegicus, Streptococcus pyogenes, Thermotoga maritima, Tritrichomonas suis
Med. Res. Rev.
28
219-232
2008
-
2
-
7
-
-
17
-
-
-
1
-
-
14
-
-
-
-
-
5
-
-
13
1
-
-
-
-
-
-
-
12
8
-
-
-
2
-
13
8
-
-
-
25
9
-
-
-
2
-
-
-
-
-
-
9
-
-
13
2
-
-
-
-
-
-
-
-
-
11
12
-
-
-
706815
Brandhorst
Multicenter evaluation of a ne ...
Homo sapiens
Ther. Drug Monit.
30
428-433
2008
-
1
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
685417
Mizushina
Inhibitory action of polyunsat ...
Mus musculus
Biochimie
89
581-590
2007
-
-
-
1
-
-
3
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
1
-
-
1
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
686145
Bremer
Real-time PCR determination of ...
Homo sapiens
Clin. Chem.
53
1023-1029
2007
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688258
Chen
Probing binding requirements o ...
Homo sapiens
J. Med. Chem.
50
5743-5751
2007
-
-
-
1
-
-
7
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
12
-
-
-
-
-
-
1
-
-
-
7
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688266
Chen
Dual inhibitors of inosine mon ...
Homo sapiens
J. Med. Chem.
50
6685-6691
2007
-
-
-
-
-
-
4
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
4
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688888
Dobie
Kinetic characterization of in ...
Leishmania donovani
Mol. Biochem. Parasitol.
152
11-21
2007
-
-
1
-
-
-
3
2
1
-
2
-
-
3
-
-
-
-
-
-
-
1
1
2
-
-
-
-
-
-
-
-
3
-
-
-
-
1
-
-
-
-
-
3
3
2
1
-
2
-
-
-
-
-
-
-
-
1
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689095
Spellicy
Characterization of retinal in ...
Canis lupus familiaris, Homo sapiens, Mus musculus, Ovis aries, Rattus norvegicus
Mol. Vis.
13
1866-1872
2007
-
-
-
-
-
-
-
-
-
-
2
-
-
14
-
-
-
-
-
6
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
6
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
689355
Wang
A novel variant L263F in human ...
Homo sapiens
Pharmacogenet. Genomics
17
283-290
2007
-
-
-
-
2
-
1
4
-
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
2
-
-
1
2
4
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
690045
Vethe
IMP dehydrogenase basal activi ...
Homo sapiens
Scand. J. Clin. Lab. Invest.
68
277-285
2007
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
690117
Patel
Effect of Diabetes mellitus on ...
Homo sapiens
Ther. Drug Monit.
29
735-742
2007
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667976
Beevers
Low molecular weight indole fr ...
Homo sapiens
Bioorg. Med. Chem. Lett.
16
2535-2538
2006
-
-
-
-
-
-
14
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
1
-
-
-
3
14
-
-
-
-
-
1
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667980
Watkins
Phosphonic acid-containing ana ...
Homo sapiens
Bioorg. Med. Chem. Lett.
16
3479-3483
2006
-
-
-
-
-
-
24
-
-
-
-
1
-
1
-
-
-
-
-
1
-
-
2
-
1
-
-
-
1
-
-
1
-
-
23
-
-
-
1
-
-
-
23
24
-
-
-
-
-
1
-
-
-
-
-
1
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
668295
Dubsky
Inosine 5-monophosphate dehydr ...
Homo sapiens
Clin. Chim. Acta
364
139-147
2006
-
-
-
-
-
-
1
-
-
-
-
1
-
2
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
668351
Hedstrom
IMP dehydrogenase: structural ...
Homo sapiens, Tritrichomonas suis
Curr. Opin. Chem. Biol.
10
520-525
2006
-
1
-
-
1
-
7
-
-
-
-
2
-
2
-
-
-
2
-
-
1
-
2
2
-
-
-
-
-
-
-
4
-
-
-
-
1
-
4
-
1
-
-
7
-
-
-
-
-
2
-
-
-
-
-
-
1
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669476
Ji
Regulation of the interaction ...
Homo sapiens
J. Biol. Chem.
281
206-212
2006
1
1
1
-
-
-
1
-
-
-
-
1
-
2
-
-
1
-
-
3
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
1
1
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
1
-
3
-
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
669800
Chong
Identification of type 1 inosi ...
Homo sapiens
J. Med. Chem.
49
2677-2680
2006
-
1
-
-
1
-
1
-
-
-
-
1
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
-
-
1
-
2
1
-
-
-
-
-
1
-
-
-
-
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
669807
Rejman
Novel methylenephosphophosphon ...
Homo sapiens
J. Med. Chem.
49
5018-5022
2006
-
1
-
-
-
-
10
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
4
-
-
-
1
-
-
-
-
-
-
10
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
670881
Vethe
Inosine monophosphate dehydrog ...
Homo sapiens
Scand. J. Clin. Lab. Invest.
66
31-44
2006
-
1
-
-
-
-
1
-
-
-
-
1
-
2
-
-
-
-
-
2
1
-
2
-
-
-
-
-
-
-
-
1
1
-
-
-
1
-
1
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
2
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667219
Sullivan
IMP dehydrogenase from the pro ...
Toxoplasma gondii
Antimicrob. Agents Chemother.
49
2172-2179
2005
-
1
1
-
-
-
8
1
-
-
-
2
-
3
-
-
1
-
-
1
1
-
2
-
1
-
-
2
1
-
-
1
6
-
-
-
1
1
1
-
-
-
-
8
6
1
-
-
-
2
-
-
-
1
-
1
1
-
2
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
667508
Mortimer
Autosomal dominant retinitis p ...
Homo sapiens
Biochem. J.
390
41-47
2005
-
-
1
-
4
-
1
9
2
-
-
2
-
1
-
-
1
-
-
-
-
-
4
1
1
-
-
5
1
-
-
1
3
-
-
-
-
1
1
-
4
-
-
1
3
9
2
-
-
2
-
-
-
1
-
-
-
-
4
1
1
-
-
5
1
-
-
-
-
-
-
-
-
-
667626
Guillen Schlippe
Is Arg418 the catalytic base r ...
Tritrichomonas suis
Biochemistry
44
11700-11707
2005
-
-
-
-
5
-
-
1
-
-
-
1
-
1
-
-
-
1
-
-
-
-
1
-
1
-
-
-
1
2
-
2
1
-
-
-
-
-
2
-
5
-
-
-
1
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
2
-
-
-
-
-
-
-
-
667644
Guillen Schlippe
Guanidine derivatives rescue t ...
Tritrichomonas suis
Biochemistry
44
16695-16700
2005
-
-
1
-
2
-
-
1
-
1
-
1
-
2
-
-
-
1
-
-
-
-
1
-
1
-
-
-
1
-
-
2
-
-
-
-
-
1
2
-
2
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
667921
Franchetti
Synthesis, conformational anal ...
Homo sapiens
Bioorg. Med. Chem.
13
2045-2053
2005
-
-
1
-
-
-
5
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
2
1
1
-
-
-
1
-
-
1
7
-
-
-
-
1
1
-
-
-
-
5
7
-
-
-
-
1
-
-
-
1
-
-
-
-
2
1
1
-
-
-
1
-
-
-
-
-
-
-
-
-
667965
Birch
Novel 7-methoxy-6-oxazol-5-yl- ...
Homo sapiens
Bioorg. Med. Chem. Lett.
15
5335-5339
2005
-
-
-
-
-
-
24
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
21
-
-
-
1
-
-
-
21
24
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
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Buckley
Quinazolinethiones and quinazo ...
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Bioorg. Med. Chem. Lett.
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2005
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1
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1
7
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The functional basis of mycoph ...
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1
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1
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1
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2
9
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1
2
-
1
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4
9
-
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1
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1
-
-
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1
-
1
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1
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-
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670128
Penuelas
Sensitization of human erythro ...
Homo sapiens
Med. Sci. Monit.
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2005
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1
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1
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1
1
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4
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1
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
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667473
McLean
Inosine 5'-monophosphate dehyd ...
Escherichia coli, Homo sapiens, Tritrichomonas suis
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2004
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2
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2
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3
3
1
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-
-
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9
3
-
-
-
-
3
-
-
3
-
-
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2
3
-
2
-
-
3
-
3
1
-
-
3
-
-
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1
-
-
-
-
9
3
-
-
-
-
3
-
-
-
-
-
-
-
-
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728783
Park
Identification and characteriz ...
Halobacterium salinarum, Halobacterium salinarum NRC 34002
Proteomics
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2004
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1
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5
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1
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2
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4
-
1
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-
1
-
-
-
-
-
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-
-
1
-
-
-
-
-
-
-
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1
-
2
-
-
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1
-
-
2
-
4
-
1
-
-
-
1
-
-
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-
1
1
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-
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667935
Iwanowicz
Inhibitors of inosine monophos ...
Homo sapiens
Bioorg. Med. Chem. Lett.
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2003
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52
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1
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1
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-
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-
2
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-
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-
-
-
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1
-
-
49
-
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1
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-
-
49
52
-
-
-
-
-
1
-
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-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667937
Dhar
3-Cyanoindole-based inhibitors ...
Homo sapiens
Bioorg. Med. Chem. Lett.
13
3557-3560
2003
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-
-
-
-
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5
-
-
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1
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1
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-
1
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-
2
-
-
-
-
-
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1
-
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5
-
-
-
1
-
-
-
5
5
-
-
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-
-
1
-
-
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-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667938
Watterson
Novel inhibitors of IMPDH: a h ...
Homo sapiens
Bioorg. Med. Chem. Lett.
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543-546
2003
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-
-
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20
-
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1
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1
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-
2
-
-
-
-
-
-
-
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1
1
-
17
-
-
-
1
-
-
-
17
20
1
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667573
Gan
Crystal structure of a ternary ...
Tritrichomonas suis
Biochemistry
41
13309-13317
2002
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1
1
1
-
-
5
8
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1
-
1
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3
-
-
1
1
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-
-
-
2
-
1
-
-
4
1
-
-
1
2
-
-
-
1
1
1
1
-
-
-
5
2
8
-
1
-
1
-
-
-
1
-
-
-
-
2
-
1
-
-
4
1
-
-
-
-
-
-
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-
-
347964
Barnes
Implications of selective type ...
Homo sapiens
Biochem. Pharmacol.
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2001
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-
-
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1
-
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-
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1
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-
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-
-
-
-
-
-
-
-
-
-
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-
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347963
Kim
Molecular cloning, overproduct ...
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64
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2000
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-
-
-
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3
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3
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1
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3
1
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-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
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1
-
-
-
-
3
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
347965
Albrecht
Development and application of ...
Homo sapiens
Ther. Drug Monit.
22
283-294
2000
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-
-
-
-
-
-
-
-
-
-
-
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2
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-
-
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-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
347959
Zhang
Characteristics and crystal st ...
Streptococcus pyogenes
Biochemistry
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4691-4700
1999
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1
1
4
-
4
2
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2
2
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2
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1
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-
1
2
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-
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1
1
-
-
-
-
-
-
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-
1
-
1
4
-
-
4
-
2
-
2
2
-
-
-
-
1
-
-
-
-
1
2
-
-
-
1
1
-
-
-
-
-
-
-
-
-
347960
Goldstein
IMP dehydrogenase: Structural ...
Borreliella burgdorferi, Cricetulus griseus, Homo sapiens, Streptococcus pyogenes, Tritrichomonas suis
Curr. Med. Chem.
6
519-536
1999
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-
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4
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5
2
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9
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2
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-
-
-
-
-
-
-
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-
-
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-
-
-
-
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-
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4
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-
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5
2
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-
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-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
347961
Hedstrom
IMP dehydrogenase: Mechanism o ...
Borreliella burgdorferi, Eimeria tenella, Escherichia coli, Homo sapiens, Rattus norvegicus, Tritrichomonas suis
Curr. Med. Chem.
6
545-560
1999
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1
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6
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1
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6
-
6
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-
-
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-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
347962
Digits J.A.; Hedstrom L.
Species-specific inhibition of ...
Homo sapiens, Tritrichomonas suis
Biochemistry
38
15388-15397
1999
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-
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6
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2
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2
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6
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2
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1
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347966
Colby
Crystal structure of human typ ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
30
3531-3536
1999
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1
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1
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347958
Miyamoto
Purification and some properti ...
Bacillus cereus
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153
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1998
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3
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347952
Griesmacher
IMP-dehydrogenase inhibition i ...
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1997
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Farazi
Isolation and characterization ...
Homo sapiens
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1997
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1
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Bruzzese
Allosteric properties of inosi ...
Cricetulus griseus
Biochemistry
36
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1997
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1
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347955
Zhou
Expression, purification, and ...
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1
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1
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1
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5
1
1
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3
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1
-
1
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1
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347957
O'Gara
IMP dehydrogenase from Pneumoc ...
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347950
Nelson
Structure-activity relationshi ...
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Xiang
Monovalent cation activation a ...
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722326
Collart
Cloning, characterization and ...
Pyrococcus furiosus
Gene
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1
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1
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1
1
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1
1
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347948
Hager
Recombinant human inosine mono ...
Homo sapiens
Biochem. Pharmacol.
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1995
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1
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2
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347949
Beck
Cloning, swquencing, and struc ...
Tritrichomonas suis
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347947
Pugh
Inosine monophosphate dehydrog ...
Sus scrofa
Comp. Biochem. Physiol. B
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1993
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6
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6
3
2
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347956
Carr
Characterization of human type ...
Homo sapiens
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347904
Wilson
Amplification and molecular cl ...
Leishmania donovani, Leishmania donovani MPA100
J. Biol. Chem.
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1665-1671
1991
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347907
Kanzaki
Nucleotide sequence of the Bac ...
Bacillus subtilis
Nucleic Acids Res.
18
6710
1990
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347918
Yamada
IMP dehydrogenase and action o ...
Homo sapiens
Biochim. Biophys. Acta
1051
209-214
1990
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1
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1
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347916
Weber
Clinical and molecular impact ...
Homo sapiens, Rattus norvegicus
Adv. Enzyme Regul.
28
335-356
1989
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1
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8
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9
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14
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14
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9
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4
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347905
Collart
Cloning and sequence analysis ...
Cricetulus griseus, Homo sapiens
J. Biol. Chem.
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15769-15772
1988
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347915
Yamada
Action of the active metabolit ...
Rattus norvegicus
Biochemistry
27
2193-2196
1988
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2
6
3
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347914
Page
Inhibition of inosine monophos ...
Mus musculus
Biochim. Biophys. Acta
926
186-194
1987
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2
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347919
Cooney
A simple method for the rapid ...
Escherichia coli, Mus musculus
Biochim. Biophys. Acta
916
89-93
1987
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347906
Miyagawa
-
Cloning of the Bacillus subtil ...
Bacillus subtilis, Bacillus subtilis NA7821
Bio/Technology
4
225-228
1986
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3
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2
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347913
Hupe
IMP dehydrogenase from the int ...
Eimeria tenella
J. Biol. Chem.
261
8363-8369
1986
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2
2
1
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2
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1
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1
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347917
Robins
The importance of IMP dehydrog ...
Chlorocebus aethiops, Parainfluenza virus, Vaccinia virus, Vaccinia virus Elstree
Adv. Enzyme Regul.
24
29-43
1985
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11
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4
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7
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347936
Atkins
Purification and properties of ...
Vigna unguiculata
Arch. Biochem. Biophys.
236
807-814
1985
2
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1
5
3
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3
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1
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1
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347912
Lui
Modulation of IMP dehydrogenas ...
Homo sapiens
J. Biol. Chem.
259
5078-5082
1984
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1
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347911
Cooney
Studies on the mechanism of ac ...
Escherichia coli
Adv. Enzyme Regul.
21
271-303
1983
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3
3
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1
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347933
Shelp
Role of inosine monophosphate ...
Vigna unguiculata
Plant Physiol.
72
1029-1034
1983
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2
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1
1
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1
2
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1
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347937
Okada
IMP dehydrogenase. II. Purific ...
Rattus norvegicus
J. Biochem.
94
1605-1613
1983
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6
1
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2
3
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3
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1
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1
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1
1
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347910
Kuttan
Inhibition of inosinate dehydr ...
Cricetulus griseus
Biochem. Biophys. Res. Commun.
107
862-868
1982
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3
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1
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347929
Gilbert
Active-site modification of na ...
Escherichia coli
Biochem. J.
191
533-541
1980
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5
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1
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347938
Lowe
The purification of inosine 5- ...
Escherichia coli
Anal. Biochem.
104
23-28
1980
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1
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1
1
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1
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2
1
1
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1
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-
347939
Gilbert
Inosine 5-monophosphate dehydr ...
Escherichia coli
Biochem. J.
183
481-494
1979
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1
1
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1
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1
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1
1
1
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347940
Jackson
Partial purification, properti ...
Rattus norvegicus
Biochem. J.
166
1-10
1977
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10
1
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5
2
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1
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1
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10
1
1
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5
2
1
1
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1
1
-
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-
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347924
Heyde
Studies on inosine monophospha ...
Enterobacter aerogenes
Biochim. Biophys. Acta
429
645-660
1976
-
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5
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2
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1
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1
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347925
Heyde
Studies on inosine monophospha ...
Enterobacter aerogenes
Biochim. Biophys. Acta
429
661-671
1976
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1
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1
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347935
Heyde
Studies on inosine monophospha ...
Enterobacter aerogenes
Biochim. Biophys. Acta
429
635-644
1976
1
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1
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2
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2
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1
2
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347932
Jackson
IMP dehydrogenase, an enzyme l ...
Rattus norvegicus
Nature
256
331-333
1975
-
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2
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1
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1
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1
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2
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2
1
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2
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1
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347941
Krishnaiah
Inosinic acid 5-monophosphate ...
Escherichia coli
Arch. Biochem. Biophys.
170
567-575
1975
-
-
-
-
-
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1
4
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1
2
1
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1
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1
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1
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2
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2
1
1
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1
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1
2
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1
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1
2
4
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1
2
1
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1
1
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2
-
2
1
1
-
-
-
1
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-
-
-
-
-
-
-
-
347931
Holmes
Human IMP dehydrogenase. Kinet ...
Homo sapiens
Biochim. Biophys. Acta
364
209-217
1974
-
-
-
-
-
-
7
3
1
2
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2
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1
1
-
1
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1
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-
-
-
-
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1
3
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1
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7
3
3
1
2
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1
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1
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1
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-
347909
Lambden
Inosine 5-monophosphate dehydr ...
Escherichia coli
Biochem. J.
133
607-608
1973
-
-
-
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1
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1
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1
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1
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1
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1
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1
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1
-
1
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-
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-
-
-
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-
-
347934
Powell
Subunit structure of inosinic ...
Escherichia coli
Biochemistry
12
1592-1595
1973
1
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1
3
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2
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1
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3
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1
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1
1
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-
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-
-
347942
Yokosawa
Studies on inosine-5-phosphate ...
Bacillus subtilis
Biochim. Biophys. Acta
227
538-553
1971
-
-
-
-
-
1
2
3
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1
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1
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1
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1
1
1
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1
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1
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1
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1
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1
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2
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3
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1
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1
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1
1
1
-
1
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-
1
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-
-
-
-
-
-
-
-
347926
Brox
Inosine-5-phosphate dehydrogen ...
Enterobacter aerogenes
Biochim. Biophys. Acta
206
215-223
1970
-
-
-
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-
1
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1
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2
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1
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1
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1
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1
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1
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1
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1
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1
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347927
Nagata
Intracellular localization of ...
Gallus gallus
Biochim. Biophys. Acta
177
680-682
1969
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2
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2
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2
1
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1
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1
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2
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2
1
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1
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347928
Hampton
Analogs of inosine 5-phosphate ...
Enterobacter aerogenes
Biochemistry
8
2303-2311
1969
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-
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3
3
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1
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1
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4
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1
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1
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3
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3
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4
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347930
Pourquie
Regulation of the biosynthesis ...
Schizosaccharomyces pombe
Biochim. Biophys. Acta
185
310-315
1969
1
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7
1
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2
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1
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1
1
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7
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1
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1
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1
1
1
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1
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347946
Powell
Rajagopalan KV, Handler P: Pur ...
Escherichia coli
J. Biol. Chem.
244
4793-4797
1969
1
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9
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3
1
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2
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1
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1
3
1
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1
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1
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4
1
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1
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4
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9
1
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3
1
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1
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1
3
1
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1
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1
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347921
Buzzee
Demonstration of an effector s ...
Salmonella enterica subsp. enterica serovar Typhimurium
Biochem. Biophys. Res. Commun.
30
673-677
1968
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1
2
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1
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1
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3
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1
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1
1
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1
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1
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1
1
2
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1
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1
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3
-
1
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1
1
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347922
Ishii
Regulation of purine ribonucle ...
Bacillus subtilis, Bacillus subtilis M
J. Biochem.
63
661-669
1968
1
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7
3
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1
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4
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1
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1
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2
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1
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7
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3
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1
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1
1
2
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1
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347923
Brox
Inosine 5-phosphate dehydrogen ...
Enterobacter aerogenes
Biochemistry
7
2589-2596
1968
-
-
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5
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1
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1
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1
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1
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1
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1
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5
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1
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1
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347945
Anderson
Inosinic acid dehydrogenase of ...
Mus musculus
J. Biol. Chem.
243
4762-4768
1968
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8
1
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3
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1
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1
1
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1
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1
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1
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8
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1
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3
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1
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1
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1
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347908
Hampton
Inosine 5-phosphate dehydrogen ...
Enterobacter aerogenes
Biochemistry
6
679-689
1967
2
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1
5
3
-
2
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1
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1
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1
1
2
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1
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1
2
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2
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1
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1
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5
2
3
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2
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1
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1
1
2
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1
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347920
Nichol
Studies on phosphate binding s ...
Enterobacter aerogenes
Biochemistry
6
1008-1015
1967
-
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6
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1
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1
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1
1
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1
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6
1
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1
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347943
Turner
Inosine 5'-phosphate dehydroge ...
Pisum sativum
Biochem. J.
79
147-151
1961
-
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3
1
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2
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2
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1
2
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1
2
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1
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1
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3
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1
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1
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2
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1
2
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1
2
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347944
Magasanik
Enzymes essential for the bios ...
Enterobacter aerogenes
J. Biol. Chem.
226
339-350
1957
2
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1
2
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1
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1
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1
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