Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-mercaptopurine ribonucleotide | - |
Homo sapiens | |
allopurinol ribonucleotide | - |
Homo sapiens | |
AMP | - |
Homo sapiens | |
GMP | - |
Homo sapiens | |
additional information | inhibition by purine and pyrimidine compounds | Homo sapiens | |
Mycophenolic acid | - |
Homo sapiens | |
xanthosine 5'-phosphate | competitive with respect to IMP | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.014 | - |
IMP | - |
Homo sapiens | |
0.046 | - |
NAD+ | - |
Homo sapiens | |
17 | - |
K+ | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | monovalent cation required for maximal activity | Homo sapiens | |
NH4+ | K+ can be partially replaced by NH4+ | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
IMP + NAD+ + H2O = XMP + NADH + H+ | ordered sequential mechanism | Homo sapiens | |
IMP + NAD+ + H2O = XMP + NADH + H+ | IMP binds first, XMP is released last | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
inosine 5'-phosphate + NAD+ + H2O | - |
Homo sapiens | xanthosine 5'-phosphate + NADH | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.03 | - |
xanthosine 5'-phosphate | - |
Homo sapiens | |
0.1 | - |
GMP | - |
Homo sapiens | |
0.53 | - |
AMP | - |
Homo sapiens |