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Literature summary for 1.1.1.205 extracted from

  • Page, J.D.; Chaney, S.G.; Hall, I.H.; Lee, K.H.; Holbrook, D.J.
    Inhibition of inosine monophosphate dehydrogenase by sesquiterpene lactones (1987), Biochim. Biophys. Acta, 926, 186-194.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Mycophenolic acid mixed type inhibition Mus musculus
Sesquiterpene lactones a class of anti-neoplastic drugs, overview Mus musculus
xanthosine 5'-phosphate competitive inhibition Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.012
-
IMP
-
Mus musculus
0.025
-
NAD+
-
Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
56000
-
SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
P-388 lymphocytic leucemia tumor cells Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
P-388 cell
-
Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.236
-
-
Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inosine 5'-phosphate + NAD+ + H2O
-
Mus musculus xanthosine 5'-phosphate + NADH
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000002
-
Mycophenolic acid for the competitive component Mus musculus
0.000008
-
Mycophenolic acid for the non-competitive component Mus musculus