Literature summary for 1.1.1.205 extracted from

Cao, S.; Aboge, G.O.; Terkawi, M.A.; Zhou, M.; Luo, Y.; Yu, L.; Li, Y.; Goo, Y.; Kamyingkird, K.; Masatani, T.; Suzuki, H.; Igarashi, I.; Nishikawa, Y.; Xuan, X.
Cloning, characterization and validation of inosine 5-monophosphate dehydrogenase of Babesia gibsoni as molecular drug target (2013), Parasitol. Int., 62, 87-94.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Babesia gibsoni

Inhibitors

Inhibitors	Comment	Organism	Structure
Mycophenolic acid	inhibitory to enzyme, also inhibits growth of Babesia gibsoni cells. The treated parasite cultures have predominantly single Babesia cells as opposed to untreated cells that have both single and dividing forms as observed on day two	Babesia gibsoni

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0082	-	Inosine 5'-diphosphate	pH 8.0, 25°C	Babesia gibsoni
0.36	-	NAD+	pH 8.0, 25°C	Babesia gibsoni

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
57000	-	x * 57000, SDs-PAGE, His-tagged protein	Babesia gibsoni

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
inosine 5'-diphosphate + NAD+ + H2O	Babesia gibsoni	-	xanthosine 5'-diphosphate + NADH + H+	-	?

Organism

Organism	UniProt	Comment	Textmining
Babesia gibsoni	I3WTS0	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
inosine 5'-diphosphate + NAD+ + H2O	-	Babesia gibsoni	xanthosine 5'-diphosphate + NADH + H+	-	?

Subunits

Subunits	Comment	Organism
?	x * 57000, SDs-PAGE, His-tagged protein	Babesia gibsoni

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	-	Babesia gibsoni

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.021	-	Mycophenolic acid	pH 8.0, 25°C	Babesia gibsoni

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Release 2023.1 (January 2023)