Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | no inhibition by tiazofurin and benzamide | Leishmania amazonensis | |
Mycophenolic acid | - |
Leishmania amazonensis | |
ribavirin | - |
Leishmania amazonensis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
IMP + NAD+ + H2O | Leishmania amazonensis | - |
XMP + NADH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania amazonensis | Q2TUW2 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
promastigote | - |
Leishmania amazonensis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
IMP + NAD+ + H2O | - |
Leishmania amazonensis | XMP + NADH + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IMPDH | - |
Leishmania amazonensis |
inosine 5' monophosphate dehydrogenase | - |
Leishmania amazonensis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Leishmania amazonensis |
Organism | Comment | Expression |
---|---|---|
Leishmania amazonensis | downregulation of impdh expression under heat shock treatment | down |
General Information | Comment | Organism |
---|---|---|
malfunction | IMPDH inhibitors ribavirin and mycophenolic acid prevents cell growth and generates an apoptosis-like phenotype in sub-populations of L.eishmania amazonensis promastigotes. A subpopulation of parasites undergoes apoptosislike cell death in the nutrient poor environment of the vector gut | Leishmania amazonensis |
metabolism | IMPDH is a key enzyme in the purine nucleotide pathway | Leishmania amazonensis |
physiological function | a small percentage of Leishmania amazonensis undergoes programmed cell death (PCD) under heat shock, imitating host infection reaction, involving the enzyme IMPDH of the purine metabolism. Enzyme IMPDH is a key enzyme in the purine nucleotide pathway, and is related to cell growth and apoptosis | Leishmania amazonensis |