Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.205 extracted from

  • Mino, Y.; Naito, T.; Otsuka, A.; Ozono, S.; Kagawa, Y.; Kawakami, J.
    Inosine monophosphate dehydrogenase activity depends on plasma concentrations of mycophenolic acid and its glucuronides in kidney transplant recipients (2009), Clin. Chim. Acta, 409, 56-61.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
mycophenolate mofetil median IMPDH activity in erythrocytes is 1.73times higher in mycophenolate mofetil positive than in mycophenolate mofetil negative kidney transplant recipients. Predose IMPDH activity in erythrocytes is induced slowly by mycophenolate mofetil therapy and is dependent on mycophenolic acid, phenolic and acyl glucuronides in stable kidney transplant recipients Homo sapiens

Application

Application Comment Organism
medicine IMPDH activity in erythrocytes may be useful indicator of short-term immunosuppression and long-term exposure of the immunosuppressant mycophenolic acid Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Mycophenolic acid IMPDH activity in erythrocytes is inhibited at the peak plasma concentration of mycophenolic acid in initial kidney transplant recipients. Reduction does not coincide with the peak of the plasma concentration of phenolic and acyl glucuronides of mycophenolic acid Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
IMPDH
-
Homo sapiens
inosine monophosphate dehydrogenase
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens increase in IMPDH activity in erythrocytes after kidney transplantation up