1.1.1.205: IMP dehydrogenase

This is an abbreviated version, for detailed information about IMP dehydrogenase, go to the full flat file.

Reaction

IMP
+
NAD+
+
H2O
=
XMP
+
NADH
+
H+

Synonyms

A1S_3321, BTH_I2056, class I IMPDH, class II IMPDH, dehydrogenase, inosinate, DR63_268, EC 1.2.1.14, GBAA_0008, guaB, guaB2, IMD2, IMD3, IMD4, IMP dehydrogenase, IMP DH, IMP oxidoreductase, IMP-DH, IMP:NAD oxidoreductase, IMP:NAD+ oxidoreductase, IMPD, IMPDH, IMPDH II, IMPDH-1, IMPDH-B, IMPDH-S, IMPDH1, IMPDH2, IMPDHab, IMPDHba, IMPDHbt, IMPDHI, IMPDHII, IMPDHkp, IMPDHlpp, IMPDHnm, IMPDHpa, inosinate dehydrogenase, inosine 5' monophosphate dehydrogenase, inosine 5'-monophosphate dehydrogenase, inosine 5'-monophosphate dehydrogenase 2, inosine 5'-phosphate dehydrogenase, inosine 5-monophosphate dehydrogenase, inosine 5-monophosphate dehydrogenase type I, inosine 5’ -monophosphate dehydrogenase, inosine 5’-monophosphate dehydrogenase 2, inosine monophosphate dehydrogenase, inosine monophosphate oxidoreductase, inosine-5'-monophosphate dehydrogenase, inosine-5'-phosphate dehydrogenase, inosinic acid 5’-monophosphate dehydrogenase, inosinic acid dehydrogenase, lpg1723, mpaF, NMC1103, Raspberry protein, Rv3411c, SOI12, Superoxide-inducible protein 12, type 1 inosine monophosphate, type 2 inosine monophosphate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.205 IMP dehydrogenase

Cloned

Cloned on EC 1.1.1.205 - IMP dehydrogenase

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Bacillus subtilis
-
Chinese hamster; human
DNA and amino acid sequence determination and analysis, two splicing variants, a short and a large one, overview; DNA and amino acid sequence determination and analysis, two splicing variants, a short and a large one, overview, expression of FLAG-tagged large splicing variant in the parasite with localization in the cytoplasm
expressed in Escherichia coli
expressed in Escherichia coli strain BL21 (DE3) using a pGEX-KG vector
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expressed in Escherichia coli; expressed in Escherichia coli
-
expressed in Morris hepatoma 3924A cells
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expression as fusion protein with green fluorescence protein, in HEK-293 cell, HeLa cell and COS cell, and expression in Escherichia coli
-
expression in Escherichia coli
expression in Eshcerichia coli; expression in Eshcerichia coli
expression in HeLa cell and CHO cell; expression in HeLa cell and CHO cell
expression of full-length type I isozyme and of the His-tagged type I isozyme subdomain in Escherichia coli
-
expression of His-tagged type II IMPDH in Escherichia coli strain BL21(DE3)
-
expression of isoyzmes IMPDH I and IMPDH II in Escherichia coli strain BL21(DE3)
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expression of the full-length enzyme and the alphabeta core domain of the enzyme in Escherichia coli
-
expression of wild-type and mutant enzyme core domains in Escherichia coli
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expression of wild-type and mutant enzymes in enzyme-deficient Escherichia coli strain H712
-
expression of wild-type and mutant IMPDH1s in enzyme-deficient Escherichia coli strain H712 and in HeLa cells, in the latter as GFP-fusion proteins
gene A1S_3321, sequence comparisons, functional recombinant overexpression of the His-tagged soluble enzyme in Escherichia coli strain BL21(DE3)/pDIA17, the enzyme forms a turbid solution, regardless of the protein concentration or buffer composition
-
gene guaB, recombinant expresion of HIs8-tagged wild-type and mutant enzymes in Escherichia coli
gene guaB, recombinant overexpression of wild-type and mutant enzymes in Escherichia coli strain BL21(DE3)
gene guaB, sequence comparisons, functional recombinant overexpression of the His-tagged soluble enzyme in Escherichia coli strain BL21(DE3)/pDIA17
gene guaB, sequence comparisons, functional recombinant overexpression of the soluble His-tagged enzyme in Escherichia coli strain BL21(DE3)/pDIA17
gene guaB, sequence comparisons, recombinant expression of wild-type and mutant enzymes in Escherichia coli
-
gene guaB2, recombinant expression in Escherichia coli strain C41(DE3)
-
gene guaB2, recombinant expression of wild-type and mutant enzymes in Escherichia coli strain BL21(DE3)
-
gene IMH3, DNA sequence determination of wild-type and mutant IMH3, expression in enzyme-deficient Escherichia coli strain H712, subcloning in Escherichia coli strain DH5alpha
gene impdh, sequence comparisons, recombinant expression of N-terminally His-tagged long and short enzyme CBS-deletion mutants, BaIMPDHDELTAL and BaIMPDHDELTAS, in Escherichia coli
-
gene impdh, sequence comparisons, recombinant expression of N-terminally His-tagged long enzyme CBS-deletion mutant, ClpIMPDHDELTAL, in Escherichia coli
-
gene impdh, sequence comparisons, recombinant expression of N-terminally His-tagged long enzyme CBS-deletion mutant, VcIMPDHDELTAL, in Escherichia coli
-
gene impdh, sequence comparisons, recombinant expression of N-terminally His-tagged short enzyme CBS-deletion mutant, CjIMPDHDELTAS, in Escherichia coli
-
gene IMPDH2, recombinant expression in Escherichia coli strain BL21(DE3), subcloning in Escherichia coli strain DH5alpha
-
genes from: Leishmania donovani
-
isoform IMPDH2, expression in Escherichia coli
overexpression of IMPDH2 in human erythroleukemia K562 cells, expression analysis, the enzyme expression affects the cytotoxicity of methotrexate, overview
-
pET32 expression plasmid, from which the impdh gene is inducibly overexpressed in Escherichia coli BL21 (DE3) to produce IMPDH with a hexahistidyl N-terminus
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recombinant expression of N-terminally His-tagged enzyme in Escherichia coli strain BL21(DE3)
-
type I and type II
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type II
-