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1.1.1.205: IMP dehydrogenase

This is an abbreviated version!
For detailed information about IMP dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.205

Reaction

IMP
+
NAD+
 +
H2O
=
XMP
 +
NADH
 +
H+

Synonyms

A1S_3321, BTH_I2056, class I IMPDH, class II IMPDH, dehydrogenase, inosinate, DR63_268, EC 1.2.1.14, GBAA_0008, guaB, guaB2, IMD2, IMD3, IMD4, IMP dehydrogenase, IMP DH, IMP oxidoreductase, IMP-DH, IMP:NAD oxidoreductase, IMP:NAD+ oxidoreductase, IMPD, IMPDH, IMPDH II, IMPDH-1, IMPDH-B, IMPDH-S, IMPDH1, IMPDH2, IMPDHA, IMPDHab, IMPDHba, IMPDHbt, IMPDHI, IMPDHII, IMPDHkp, IMPDHlpp, IMPDHnm, IMPDHpa, inosinate dehydrogenase, inosine 5' monophosphate dehydrogenase, inosine 5'-monophosphate dehydrogenase, inosine 5'-monophosphate dehydrogenase 2, inosine 5'-phosphate dehydrogenase, inosine 5-monophosphate dehydrogenase, inosine 5-monophosphate dehydrogenase 2, inosine 5-monophosphate dehydrogenase type I, inosine 5’ -monophosphate dehydrogenase, inosine 5’-monophosphate dehydrogenase 2, inosine monophosphate dehydrogenase, inosine monophosphate dehydrogenase-1, inosine monophosphate dehydrogenase-2, inosine monophosphate oxidoreductase, inosine-5'-monophosphate dehydrogenase, inosine-5'-phosphate dehydrogenase, inosine-5-monophosphate dehydrogenase, inosinic acid 5’-monophosphate dehydrogenase, inosinic acid dehydrogenase, lpg1723, mpaF, NMC1103, Raspberry protein, Rv3411c, SOI12, Superoxide-inducible protein 12, type 1 inosine monophosphate, type 2 inosine monophosphate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.205 IMP dehydrogenase

IC50 Value

IC50 Value on EC 1.1.1.205 - IMP dehydrogenase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0001
(1H-naphtho[2,3-d]imidazol-2-yl)methyl 4-aminobenzoate
Cryptosporidium parvum
-
pH and temperature not specified in the publication
0.000785
(2-[acetyl[(2E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-methylbut-2-en-1-yl]amino]ethyl)phosphonic acid
Homo sapiens
-
isozyme IMPDH II IC50: 785 nM
0.000749
(2-[formyl[(2E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-methylbut-2-en-1-yl]amino]ethyl)phosphonic acid
Homo sapiens
-
isozyme IMPDH II IC50: 749 nM
0.001
(2-[[(2E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-methylbut-2-en-1-yl](methyl)amino]ethyl)phosphonic acid
Homo sapiens
-
isozyme IMPDH II IC50: above 0.001 mM
0.000498
(2-[[(2E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-methylbut-2-en-1-yl](methylsulfonyl)amino]ethyl)phosphonic acid
Homo sapiens
-
isozyme IMPDH II IC50: 498 nM
0.000093
(2-[[(2E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-methylbut-2-en-1-yl](sulfamoyl)amino]ethyl)phosphonic acid
Homo sapiens
-
isozyme IMPDH II IC50: 93 nM
0.000499
(2-[[(2E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-methylbut-2-en-1-yl]amino]ethyl)phosphonic acid
Homo sapiens
-
isozyme IMPDH II IC50: 499 nM
0.000132
(2-[[(2E)-4-(6-ethyl-4-hydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-methylbut-2-en-1-yl](methyl)amino]ethyl)phosphonic acid
Homo sapiens
-
isozyme IMPDH II IC50: 132 nM
0.000068
(2-[[(2E)-4-(6-ethyl-4-hydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-methylbut-2-en-1-yl](methylsulfonyl)amino]ethyl)phosphonic acid
Homo sapiens
-
isozyme IMPDH II IC50: 68 nM
0.000024
(2-[[(2E)-4-(6-ethyl-4-hydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-methylbut-2-en-1-yl](sulfamoyl)amino]ethyl)phosphonic acid
Homo sapiens
-
isozyme IMPDH II IC50: 24 nM
0.000013
(2-[[(2E)-4-(6-ethyl-4-hydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-methylbut-2-en-1-yl]amino]ethyl)phosphonic acid
Homo sapiens
-
isozyme IMPDH II IC50: 13 nM
0.000028
(2E)-3-furan-2-yl-N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]prop-2-enamide
0.002
(2E)-3-furan-2-yl-N-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]prop-2-enamide
Homo sapiens
-
isozyme IMPDH II IC50: 0.002 mM
0.000014
(2S)-2-[(1-naphthyl)amino]-N-[2-(pyridin-4-yl)-1,3-benzoxazol-5-yl]propanamide
Cryptosporidium parvum
pH 8.0, 25°C
0.0000005
(2S)-2-[(3,4-dichlorophenyl)amino]-N-[2-(pyridin-4-yl)-1,3-benzoxazol-5-yl]propanamide
Cryptosporidium parvum
pH 8.0, 25°C
0.00015 - 0.00017
(4E)-6-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid
0.00082
(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-N-[(2R)-2-phenylpropyl]hex-4-enamide
Homo sapiens
isoform IMPDH2, at pH 8.6 and 37°C
0.0005
(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-N-[2-(2-methylphenyl)ethyl]hex-4-enamide
Homo sapiens
isoform IMPDH2, at pH 8.6 and 37°C
0.0006
(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methyl-N-[2-(4-methylphenyl)ethyl]hex-4-enamide
Homo sapiens
isoform IMPDH2, at pH 8.6 and 37°C
0.00033
(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-N-[2-(4-methoxyphenyl)ethyl]-4-methylhex-4-enamide
Homo sapiens
isoform IMPDH2, at pH 8.6 and 37°C
0.0041
(4E)-6-[4-(acetyloxy)-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl]-4-methylhex-4-enoic acid
Homo sapiens
pH 7.4, 37°C
0.00035 - 0.00042
(4E)-N-hydroxy-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enamide
0.00048
(4E)-N-[(4-butylphenyl)methyl]-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enamide
Homo sapiens
isoform IMPDH2, at pH 8.6 and 37°C
0.00073
(4E)-N-[2-(2-chlorophenyl)ethyl]-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enamide
Homo sapiens
isoform IMPDH2, at pH 8.6 and 37°C
0.00051
(4E)-N-[2-(2H-1,3-benzodioxol-5-yl)ethyl]-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enamide
Homo sapiens
isoform IMPDH2, at pH 8.6 and 37°C
0.00057
(4E)-N-[2-(4-chlorophenyl)ethyl]-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enamide
Homo sapiens
isoform IMPDH2, at pH 8.6 and 37°C
0.000246
([[(2E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-methylbut-2-en-1-yl]oxy]methyl)phosphonic acid
Homo sapiens
-
isozyme IMPDH II IC50: 246 nM
0.000023
([[(2E)-4-(6-ethyl-4-hydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-methylbut-2-en-1-yl]oxy]methyl)phosphonic acid
Homo sapiens
-
isozyme IMPDH II IC50: 23 nM
0.0019
1,4-dimethyl-6-nitro-2H-cyclopenta[d]pyridazine
Homo sapiens
-
0.094
1-(2,2-dimethylpropanoyl)-7'-methoxy-3'-methyl-6'-(1,3-oxazol-5-yl)-1'H-spiro[pyrrolidine-3,2'-quinazolin]-4'(3'H)-one
Homo sapiens
-
IC50: 0.094 mM, isozyme IMPDH II
0.0000009
1-(2-[3-[(1E)-N-hydroxyethanimidoyl]phenyl]propan-2-yl)-3-quinolin-7-ylurea
Cryptosporidium parvum
pH 8.0, 25°C
0.00064
1-(3-methylphenyl)-3-[4-(1,3-oxazol-5-yl)phenyl]urea
Homo sapiens
-
isozyme IMPDH II IC50: 640 nM
0.00000066
1-(4-chloro-5-nitrocyclohexa-1,5-dien-1-yl)-3-(2-[3-[(1E)-N-hydroxyethanimidoyl]phenyl]propan-2-yl)urea
Cryptosporidium parvum
pH 8.0, 25°C
0.000076
1-(benzyloxy)-3-(3-pyridin-4-yl-1H-indol-6-yl)urea
Homo sapiens
-
0.000033
1-methyl-6-[(5-phenyl-1,3-oxazol-2-yl)amino]-1H-indole-3-carbonitrile
Homo sapiens
-
0.000035
1-tert-butyl 5-methyl (3R,5R)-7'-methoxy-3'-methyl-6'-(1,3-oxazol-5-yl)-4'-oxo-3',4'-dihydro-1H,1'H-spiro[pyrrolidine-3,2'-quinazoline]-1,5-dicarboxylate
Homo sapiens
-
IC50: 35 nM, isozyme IMPDH II
0.000948
1-tert-butyl 5-methyl (3R,5S)-7'-methoxy-3'-methyl-6'-(1,3-oxazol-5-yl)-4'-oxo-3',4'-dihydro-1H,1'H-spiro[pyrrolidine-3,2'-quinazoline]-1,5-dicarboxylate
Homo sapiens
-
IC50: 948 nM, isozyme IMPDH II
0.000035
1-tert-butyl 5-methyl (3S,5R)-7'-methoxy-3'-methyl-6'-(1,3-oxazol-5-yl)-4'-oxo-3',4'-dihydro-1H,1'H-spiro[pyrrolidine-3,2'-quinazoline]-1,5-dicarboxylate
Homo sapiens
-
IC50: 35 nM, isozyme IMPDH II
0.00127
1-[(3,4-dichlorophenyl)methyl]-4-[[(naphthalen-1-yl)oxy]methyl]-1H-1,2,3-triazole
Helicobacter pylori
-
at pH 7.6 and 37°C
0.0021
1-[(3-chlorophenyl)methyl]-4-[[(naphthalen-1-yl)oxy]methyl]-1H-1,2,3-triazole
Helicobacter pylori
-
at pH 7.6 and 37°C
0.0000008
1-[2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl]-3-quinolin-7-ylurea
Cryptosporidium parvum
pH 8.0, 25°C
0.000043
1-[3-chloro-4-(1,3-oxazol-5-yl)phenyl]-3-(3-methylphenyl)urea
Homo sapiens
-
isozyme IMPDH II IC50: 43 nM
0.000019
1-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-3-(3-methylphenyl)urea
Homo sapiens
-
isozyme IMPDH II IC50: 19 nM
0.0005
1-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]-3-(3-methylphenyl)urea
Homo sapiens
-
isozyme IMPDH II IC50: 500 nM
0.00002
14,16-dihydroxy-3,8-dimethyl-3,4,5,6,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione
Homo sapiens
pH 8.0, 25°C
0.00022 - 0.00055
1H-naphtho[2,3-d]imidazol-2-ylmethyl 4-aminobenzoate
0.0016
2-(1,3-oxazol-5-yl)-5-[(5-phenyl-1,3-oxazol-2-yl)amino]phenol
Homo sapiens
-
isozyme IMPDH II IC50: 0.0016 mM
0.00003
2-(1-benzothiophen-3-yl)-6-methoxy-5-(1,3-oxazol-5-yl)-1H-indole-3-carbaldehyde
Homo sapiens
-
0.000013 - 0.000095
2-(1-naphthalenyloxy)-N-[(2-(4-pyridinyl)-5-benzoxazolyl)]-(2S)-propanamide
0.0062
2-(4-benzoylphenyl)-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)propanamide
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.00304
2-(4-fluoronaphthalen-1-yl)-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0002
2-(dimethylamino)-7-methoxy-6-(1,3-oxazol-5-yl)quinolin-4(1H)-one
Homo sapiens
-
isozyme IMPDH II IC50: 200 nM
0.00018
2-benzyl-7-methoxy-6-(1,3-oxazol-5-yl)quinolin-4(1H)-one
Homo sapiens
-
isozyme IMPDH II IC50: 180 nM
0.00001 - 0.000092
2-chloro-N-methyl-5-[[[1-methyl-1-[3-(1-methylethenyl)phenyl]ethyl]amino]carbonyl]aminobenzamide
0.00024
2-cyano-1-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-3-phenylguanidine
Homo sapiens
-
isozyme IMPDH II IC50: 240 nM
0.000073 - 0.000099
2-ethyl-9-[5-O-[hydroxy(2-[hydroxy[2-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)ethoxy]phosphoryl]ethyl)phosphoryl]-beta-L-ribofuranosyl]-9H-purin-6-amine
0.000032
2-furan-3-yl-7-methoxy-6-(1,3-oxazol-5-yl)quinolin-4(1H)-one
Homo sapiens
-
isozyme IMPDH II IC50: 32 nM
0.000041
2-hydroxy-N-[2-(2-[[3-methoxy-4-(1,3-oxazol-4-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methylacetamide
Homo sapiens
-
isozyme IMPDH II IC50: 41 nM
0.000343
2-methyl-3-(pyrid-4-yl)indole
Homo sapiens
-
IC50: 343 nM
0.01
2-tert-butyl-7-methoxy-6-(1,3-oxazol-5-yl)quinolin-4(1H)-one
Homo sapiens
-
isozyme IMPDH II IC50: 0.01 mM
0.000002
2-[(3,4-dichlorophenyl)amino]-N-[2-(pyridin-4-yl)-1,3-benzoxazol-5-yl]propanamide
Cryptosporidium parvum
pH 8.0, 25°C
0.0008 - 0.013
2-[(3-ethyl-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(4-methoxyphenyl)acetamide
0.00406
2-[4-([1-[(3-methoxyphenyl)methyl]-1H-1,2,3-triazol-4-yl]methoxy)phenyl]-5-methyl-1,3,4-oxadiazole
Helicobacter pylori
-
at pH 7.6 and 37°C
0.000007
2-[methyl[2-(2-[[3-(1,3-oxazol-5-yl)-1H-indol-6-yl]amino]-1,3-oxazol-5-yl)phenyl]amino]-2-oxoethyl acetate
Homo sapiens
-
0.00188
2-[[2-(4-methoxyphenyl)-4-oxo-4H-1-benzopyran-3-yl]oxy]-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide
Helicobacter pylori
-
at pH 7.6 and 37°C
0.07
2264A
Homo sapiens
-
0.000169 - 0.0034
3,4-dihydro-3-methyl-4-oxo-N-(6,7,8,9-tetrahydro2-dibenzofuranyl)-1-phthalazineacetamide
0.00086 - 0.0012
3-(1H-naphtho[2,3-d]imidazol-2-yl)propyl 4-aminobenzoate
0.0183
3-(4-chlorophenyl)-4-(4-ethoxyphenyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid
Pseudomonas aeruginosa
pH and temperature not specified in the publication
0.000033 - 0.00042
3-cyanoindole-based inhibitors
Homo sapiens
-
synthesis and initial structure–activity relationships of 3-cyanoindole-based inhibitors with isozyme IMPDH II, IC50: 33-420 nM, comparison to other inhibitor structural classes, overview
-
0.0001
3-hydroxy-N-methyl-N-[2-(2-[[3-methyl-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]propanamide
Homo sapiens
-
isozyme IMPDH II IC50: 100 nM
0.000021
3-hydroxy-N-[2-(2-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methylpropanamide
Homo sapiens
-
isozyme IMPDH II IC50: 21 nM
0.000005 - 0.00016
3-phenyl quinolone derivatives
Homo sapiens
-
several, isozyme IMPDH II IC50: 5-160 nM, overview
-
0.0117
4-(3-bromo-4-methoxyphenyl)-3-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid
Pseudomonas aeruginosa
pH and temperature not specified in the publication
0.019
4-(4-acetamidophenyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid
Pseudomonas aeruginosa
pH and temperature not specified in the publication
0.023
4-(4-acetamidophenyl)-3-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid
Pseudomonas aeruginosa
pH and temperature not specified in the publication
0.0074
4-(5-bromo-2-fluorophenyl)-3-(4-chlorophenyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid
Pseudomonas aeruginosa
pH and temperature not specified in the publication
0.0117
4-(5-bromo-2-methoxyphenyl)-3-(4-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid
Pseudomonas aeruginosa
pH and temperature not specified in the publication
0.017
4-acetyl-N-(3-chloro-4-fluorophenyl)-3,4-dihydro-2H-1,4-benzoxazine-7-sulfonamide
Pseudomonas aeruginosa
pH and temperature not specified in the publication
0.00115
4-pyridylindole
Homo sapiens
-
IC50: 0.00115 mM
0.000057 - 0.00012
4-[(1R)-1-[1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl]ethoxy]quinoline 1-oxide
0.000043 - 0.000364
4-[(1R)-[1-(4-chlorophenyl)-1H-1,2,3-triazol-4yl]ethoxy]quinoline-1-oxide
0.1747
4-[(5-[[(naphthalen-1-yl)oxy]methyl]-1H-1,2,3-triazol-1-yl)methyl]benzonitrile
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.000018
4-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-6-phenyl-1,3,5-triazin-2-ol
Homo sapiens
-
0.000004
5-([[2-([1,1'-biphenyl]-3-yl)propan-2-yl]carbamoyl]amino)-2-chlorobenzamide
Cryptosporidium parvum
-
pH and temperature not specified in the publication
0.0005
5-bromoisoquinolin-6-amine
Homo sapiens
-
0.00076
5-chloro-1,4-dimethyl-2H-cyclopenta[d]pyridazine-6-carbonitrile
Homo sapiens
-
0.000328
7'-methoxy-3'-methyl-6'-(1,3-oxazol-5-yl)-1'H-spiro[cyclopentane-1,2'-quinazolin]-4'(3'H)-one
Homo sapiens
-
IC50: 328 nM, isozyme IMPDH II
0.068
7'-methoxy-3'-methyl-6'-(1,3-oxazol-5-yl)-1-(piperidin-1-ylcarbonyl)-1'H-spiro[pyrrolidine-3,2'-quinazolin]-4'(3'H)-one
Homo sapiens
-
IC50: 0.068 mM, isozyme IMPDH II
0.000526
7'-methoxy-3'-methyl-6'-(1,3-oxazol-5-yl)-2,3,5,6-tetrahydro-1'H-spiro[pyran-4,2'-quinazolin]-4'(3'H)-one
Homo sapiens
-
IC50: 526 nM, isozyme IMPDH II
0.393
7'-methoxy-3'-methyl-6'-(1,3-oxazol-5-yl)-4'-oxo-N-phenyl-3',4'-dihydro-1H,1'H-spiro[pyrrolidine-3,2'-quinazoline]-1-carboxamide
Homo sapiens
-
IC50: 0.393 mM, isozyme IMPDH II
0.000096
7'-methoxy-3'-methyl-6'-(1,3-oxazol-5-yl)-4,6-dihydro-1'H-spiro[cyclopenta[b]thiophene-5,2'-quinazolin]-4'(3'H)-one
Homo sapiens
-
IC50: 96 nM, isozyme IMPDH II
0.071
7'-methoxy-3'-methyl-N,N-bis(1-methylethyl)-6'-(1,3-oxazol-5-yl)-4'-oxo-3',4'-dihydro-1H,1'H-spiro[pyrrolidine-3,2'-quinazoline]-1-carboxamide
Homo sapiens
-
IC50: 0.071 mM, isozyme IMPDH II
0.064
7'-methoxy-N,3'-dimethyl-6'-(1,3-oxazol-5-yl)-4'-oxo-N-phenyl-3',4'-dihydro-1H,1'H-spiro[pyrrolidine-3,2'-quinazoline]-1-carboxamide
Homo sapiens
-
IC50: 0.064 mM, isozyme IMPDH II
0.004
7-amino-5-(4-chlorophenyl)-2,4-dioxo-1,3,4,5-tetrahydro-2H-pyrano[2,3-d]pyrimidine-6-carbonitrile
Pseudomonas aeruginosa
pH and temperature not specified in the publication
0.007
7-amino-5-(4-nitrophenyl)-2,4-dioxo-1,3,4,5-tetrahydro-2H-pyrano[2,3-d]pyrimidine-6-carbonitrile
Pseudomonas aeruginosa
pH and temperature not specified in the publication
0.004
7-amino-5-(5-nitrothiophen-2-yl)-2,4-dioxo-1,3,4,5-tetrahydro-2H-pyrano[2,3-d]pyrimidine-6-carbonitrile
Pseudomonas aeruginosa
pH and temperature not specified in the publication
0.000254
7-hydroxy-5-methoxy-4-methyl-6-(3-methylbut-2-en-1-yl)-2-benzofuran-1(3H)-one
Homo sapiens
-
isozyme IMPDH II IC50: 254 nM
0.000273
7-hydroxy-5-methoxy-6-[(2E)-4-methoxy-3-methylbut-2-en-1-yl]-4-methyl-2-benzofuran-1(3H)-one
Homo sapiens
-
isozyme IMPDH II IC50: 273 nM
0.000192
7-methoxy-2,2,3-trimethyl-6-(1,3-oxazol-5-yl)-2,3-dihydroquinazolin-4(1H)-one
Homo sapiens
-
IC50: 192 nM, isozyme IMPDH II
0.0003
7-methoxy-2,2-dimethyl-6-(1,3-oxazol-5-yl)-3-(2-pyridin-4-ylethyl)-2,3-dihydroquinazolin-4(1H)-one
Homo sapiens
-
IC50: 300 nM, isozyme IMPDH II
0.000049
7-methoxy-2,3-dimethyl-6-(1,3-oxazol-5-yl)-2-[(E)-2-phenylethenyl]-2,3-dihydroquinazolin-4(1H)-one
Homo sapiens
-
IC50: 49 nM, isozyme IMPDH II
0.000005
7-methoxy-2-(3-methylphenyl)-6-(1,3-oxazol-5-yl)quinolin-4(1H)-one
Homo sapiens
-
0.00022
7-methoxy-2-(methylamino)-6-(1,3-oxazol-5-yl)quinolin-4(1H)-one
Homo sapiens
-
isozyme IMPDH II IC50: 220 nM
0.00011
7-methoxy-2-methyl-6-(1,3-oxazol-5-yl)quinolin-4(1H)-one
Homo sapiens
-
isozyme IMPDH II IC50: 110 nM
0.000065
7-methoxy-3-methyl-6-(1,3-oxazol-5-yl)-2-phenylquinolin-4(1H)-one
Homo sapiens
-
isozyme IMPDH II IC50: 65 nM
0.000104
7-methoxy-3-methyl-6-(1,3-oxazol-5-yl)quinazoline-2,4(1H,3H)-dione
Homo sapiens
-
IC50: 104 nM, isozyme IMPDH II
0.00021
7-methoxy-6-(1,3-oxazol-4-yl)-2-phenylquinolin-4(1H)-one
Homo sapiens
-
isozyme IMPDH II IC50: 210 nM
0.000034
7-methoxy-6-(1,3-oxazol-5-yl)-2-(1,3-thiazol-4-yl)quinolin-4(1H)-one
Homo sapiens
-
isozyme IMPDH II IC50: 34 nM
0.000008
7-methoxy-6-(1,3-oxazol-5-yl)-2-phenoxyquinolin-4(1H)-one
Homo sapiens
-
isozyme IMPDH II IC50: 8 nM
0.000008
7-methoxy-6-(1,3-oxazol-5-yl)-2-phenylquinolin-4(1H)-one
Homo sapiens
-
isozyme IMPDH II IC50: 8 nM
0.000043
7-methoxy-6-(1,3-oxazol-5-yl)-2-pyridin-2-ylquinolin-4(1H)-one
Homo sapiens
-
isozyme IMPDH II IC50: 43 nM
0.00007
7-methoxy-6-(1,3-oxazol-5-yl)-2-pyridin-3-ylquinolin-4(1H)-one
Homo sapiens
-
isozyme IMPDH II IC50: 70 nM
0.000046
7-methoxy-6-(1,3-oxazol-5-yl)-2-pyridin-4-ylquinolin-4(1H)-one
Homo sapiens
-
isozyme IMPDH II IC50: 46 nM
0.000063
7-methoxy-6-(1,3-oxazol-5-yl)-2-thiophen-2-ylquinolin-4(1H)-one
Homo sapiens
-
isozyme IMPDH II IC50: 63 nM
0.000009
7-methoxy-6-(1,3-oxazol-5-yl)-2-thiophen-3-ylquinolin-4(1H)-one
Homo sapiens
-
isozyme IMPDH II IC50: 9 nM
0.000303
7-methoxy-6-(1,3-oxazol-5-yl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one
Homo sapiens
-
IC50: 303 nM
0.000013
7-methoxy-6-(1,3-oxazol-5-yl)-3-(2-pyridin-4-ylethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one
Homo sapiens
-
0.0003
7-methoxy-6-(1,3-oxazol-5-yl)quinolin-4(1H)-one
Homo sapiens
-
isozyme IMPDH II IC50: 300 nM
0.000037
9-(5-O-[hydroxy[([hydroxy[2-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)ethoxy]phosphoryl]oxy)methyl]phosphoryl]-beta-L-ribofuranosyl)-9H-purin-6-amine
Homo sapiens
pH 8.0, 25°C
0.000016 - 0.0082
BMS-337197
0.001
dimethyl (2-[[(2E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-methylbut-2-en-1-yl]amino]ethyl)phosphonate
Homo sapiens
-
isozyme IMPDH II IC50: above 0.001 mM
0.000289
dimethyl [(2E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-methylbut-2-en-1-yl]phosphonate
Homo sapiens
-
isozyme IMPDH II IC50: 289 nM
0.0161
eicosadienoic acid
Mus musculus
-
pH 8.0, 37°C
0.08
ethyl 7'-methoxy-3'-methyl-6'-(1,3-oxazol-5-yl)-4'-oxo-3',4'-dihydro-1H,1'H-spiro[pyrrolidine-3,2'-quinazoline]-1-carboxylate
Homo sapiens
-
IC50: 0.08 mM, isozyme IMPDH II
0.00073
ethyl 9-oxo-9,10-dihydroacridine-1-carboxylate
Homo sapiens
-
0.0014 - 0.0015
methyl (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoate
0.0009 - 0.015
methyl 3-methyl-2-oxo-1,2-dihydroquinoline-4-carboxylate
0.000005 - 0.000024
mycophenolic 2-ethyladenosin-5'-yl-difluoromethylenebis(phosphonate)
0.000016 - 0.000038
mycophenolic 2-ethyladenosin-5'-yl-methylenebis(phosphonate)
0.000007 - 0.0272
Mycophenolic acid
0.079
N,7'-dimethoxy-N,3'-dimethyl-6'-(1,3-oxazol-5-yl)-4'-oxo-3',4'-dihydro-1H,1'H-spiro[pyrrolidine-3,2'-quinazoline]-1-carboxamide
Homo sapiens
-
IC50: 0.079 mM, isozyme IMPDH II
0.045
N,N-diethyl-7'-methoxy-3'-methyl-6'-(1,3-oxazol-5-yl)-4'-oxo-3',4'-dihydro-1H,1'H-spiro[pyrrolidine-3,2'-quinazoline]-1-carboxamide
Homo sapiens
-
IC50: 0.045 mM, isozyme IMPDH II
0.000018
N-(2,3-dichlorophenyl)-2-[2-(1,3-thiazol-2-yl)-1H-benzimidazol-1-yl]acetamide
Cryptosporidium parvum
pH not specified in the publication, temperature not specified in the publication
0.051
N-(2,4-difluorophenyl)-7'-methoxy-N,3'-dimethyl-6'-(1,3-oxazol-5-yl)-4'-oxo-3',4'-dihydro-1H,1'H-spiro[pyrrolidine-3,2'-quinazoline]-1-carboxamide
Homo sapiens
-
IC50: 0.051 mM, isozyme IMPDH II
0.000028
N-(4-bromophenyl)-2-[2-(1,3-thiazol-2-yl)-1H-benzimidazol-1-yl]acetamide
Cryptosporidium parvum
pH not specified in the publication, temperature not specified in the publication
0.000015 - 0.000067
N-(4-bromophenyl)-N-[(1-methylethenyl)phenyl]ethyl urea
0.000006 - 0.000066
N-(4-bromophenyl)-N-[1-[3-[1-(hydroxyimino)ethyl]phenyl]-1-methylethyl] urea
0.0033
N-(4-chlorophenyl)-2-phenoxypropanamide
Cryptosporidium parvum
-
pH and temperature not specified in the publication
0.0017 - 0.049
N-(4-methoxyphenyl)-2-(3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
0.0016
N-(4-methoxyphenyl)-2-(naphthalen-1-yl)acetamide
Cryptosporidium parvum
-
pH and temperature not specified in the publication
0.0006 - 0.07
N-(4-methoxyphenyl)-2-[2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetamide
0.000005
N-(5-phenyl-1,3-oxazol-2-yl)isoquinolin-6-amine
Homo sapiens
-
0.000008
N-(naphthalen-2-yl)-2-[2-(1,3-thiazol-2-yl)-1H-benzimidazol-1-yl]acetamide
Cryptosporidium parvum
pH not specified in the publication, temperature not specified in the publication
0.000007
N-(naphthalen-2-yl)-2-[2-(1,3-thiazol-4-yl)-1H-benzimidazol-1-yl]acetamide
Cryptosporidium parvum
pH not specified in the publication, temperature not specified in the publication
0.000042 - 0.00057
N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]acetamide
0.0000011 - 0.0000054
N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-5,6-dihydro-1H-benzimidazol-1-yl]acetamide
0.119
N-ethyl-7'-methoxy-3'-methyl-6'-(1,3-oxazol-5-yl)-4'-oxo-3',4'-dihydro-1H,1'H-spiro[pyrrolidine-3,2'-quinazoline]-1-carboxamide
Homo sapiens
-
IC50: 0.119 mM, isozyme IMPDH II
0.005
N-methyl-N'-[4-(1,3-oxazol-5-yl)phenyl]-6-phenyl-1,3,5-triazine-2,4-diamine
Homo sapiens
-
isozyme IMPDH II IC50: 0.005 mM
0.005
N-methyl-N'-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]-6-phenyl-1,3,5-triazine-2,4-diamine
Homo sapiens
-
isozyme IMPDH II IC50: 0.005 mM
0.000045
N-methyl-N-[2-(2-[[3-methyl-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-3-morpholin-4-ylpropanamide
Homo sapiens
-
isozyme IMPDH II IC50: 45 nM
0.0000021
N-naphthalen-2-yl-N'-[2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl]urea
Cryptosporidium parvum
-
pH and temperature not specified in the publication
0.000055
N-tert-butyl-N'-[3-chloro-4-(1,3-oxazol-5-yl)phenyl]ethanediamide
Homo sapiens
-
isozyme IMPDH II IC50: 55 nM
0.00001
N-tert-butyl-N'-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]ethanediamide
Homo sapiens
-
isozyme IMPDH II IC50: 10 nM
0.005
N-tert-butyl-N'-[4-(1,3-oxazol-5-yl)phenyl]ethanediamide
Homo sapiens
-
isozyme IMPDH II IC50: 0.005 mM
0.005
N-tert-butyl-N'-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]ethanediamide
Homo sapiens
-
isozyme IMPDH II IC50: 0.005 mM
0.000017
N-[1-[6-(4-ethylpiperazin-1-yl)pyridin-3-yl]-1-methylethyl]-2-fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide
Homo sapiens
-
0.000047
N-[2-(2-[[3-(chloromethyl)-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-3-morpholin-4-ylpropanamide
Homo sapiens
-
isozyme IMPDH II IC50: 47 nM
0.000028
N-[2-(2-[[3-bromo-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-3-hydroxy-N-methylpropanamide
Homo sapiens
-
isozyme IMPDH II IC50: 28 nM
0.000021
N-[2-(2-[[3-bromo-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-3-morpholin-4-ylpropanamide
Homo sapiens
-
isozyme IMPDH II IC50: 21 nM
0.000048
N-[2-(2-[[3-chloro-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-3-hydroxy-N-methylpropanamide
Homo sapiens
-
isozyme IMPDH II IC50: 48 nM
0.00031
N-[2-(2-[[3-ethyl-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-3-hydroxy-N-methylpropanamide
Homo sapiens
-
isozyme IMPDH II IC50: 310 nM
0.000021
N-[2-(2-[[3-ethyl-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-3-morpholin-4-ylpropanamide
Homo sapiens
-
isozyme IMPDH II IC50: 21 nM
0.000091
N-[2-(2-[[3-methoxy-4-(1,3-oxazol-4-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-2-morpholin-4-ylacetamide
Homo sapiens
-
isozyme IMPDH II IC50: 91 nM
0.000012
N-[2-(2-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-2-morpholin-4-ylacetamide
Homo sapiens
-
0.000016
N-[2-(2-[[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]amino]-1,3-oxazol-5-yl)phenyl]-N-methyl-3-morpholin-4-ylpropanamide
Homo sapiens
-
isozyme IMPDH II IC50: 16 nM
0.000018
N-[2-(hydroxymethyl)cyclopentyl]-N'-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]propanediamide
Homo sapiens
-
0.005
N-[2-chloro-3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
Homo sapiens
-
isozyme IMPDH II IC50: 0.005 mM
0.0016
N-[2-chloro-5-methoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
Homo sapiens
-
isozyme IMPDH II IC50: 0.0016 mM
0.005
N-[2-fluoro-5-methoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
Homo sapiens
-
isozyme IMPDH II IC50: 0.005 mM
0.00005
N-[3-bromo-4-(1,3-oxazol-5-yl)phenyl]-N'-tert-butylethanediamide
Homo sapiens
-
isozyme IMPDH II IC50: 50 nM
0.005
N-[3-chloro-4-(1,3-oxazol-4-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
Homo sapiens
-
isozyme IMPDH II IC50: 0.005 mM
0.000088
N-[3-chloro-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
Homo sapiens
-
isozyme IMPDH II IC50: 88 nM
0.00034
N-[3-chloro-4-(1,3-oxazol-5-yl)phenyl]-N'-methyl-6-phenyl-1,3,5-triazine-2,4-diamine
Homo sapiens
-
isozyme IMPDH II IC50: 340 nM
0.01
N-[3-ethoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
Homo sapiens
-
isozyme IMPDH II IC50: 0.010 mM
0.00019
N-[3-methoxy-4-(1,3-oxazol-2-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
Homo sapiens
-
isozyme IMPDH II IC50: 190 nM
0.000057
N-[3-methoxy-4-(1,3-oxazol-4-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
Homo sapiens
-
isozyme IMPDH II IC50: 57 nM
0.0016
N-[3-methoxy-4-(1,3-oxazol-4-yl)phenyl]-N'-methyl-6-phenyl-1,3,5-triazine-2,4-diamine
Homo sapiens
-
isozyme IMPDH II IC50: 0.0016 mM
0.00002
N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
Homo sapiens
-
isozyme IMPDH II IC50: 20 nM
0.000076
N-[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]-N'-methyl-6-phenyl-1,3,5-triazine-2,4-diamine
Homo sapiens
-
isozyme IMPDH II IC50: 76 nM
0.00041
N-[3-methoxy-4-(1H-1,2,4-triazol-1-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
Homo sapiens
-
isozyme IMPDH II IC50: 410 nM
0.002
N-[3-methoxy-4-(2-methyl-1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
Homo sapiens
-
isozyme IMPDH II IC50: 0.002 mM
0.005
N-[3-methoxy-4-(4-methyl-1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
Homo sapiens
-
isozyme IMPDH II IC50: 0.005 mM
0.005
N-[3-methyl-4-(1,3-oxazol-4-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
Homo sapiens
-
isozyme IMPDH II IC50: 0.005 mM
0.005
N-[4-(1,3-oxazol-4-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
Homo sapiens
-
isozyme IMPDH II IC50: 0.005 mM
0.005
N-[4-(1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
Homo sapiens
-
isozyme IMPDH II IC50: 0.005 mM
0.0028
N-[4-(1-benzyl-2,4,6-trioxo-2,3,4,5,6,11-hexahydro-1H-indeno[2',1':5,6]pyrido[2,3-d]pyrimidin-5-yl)phenyl]acetamide
Pseudomonas aeruginosa
pH and temperature not specified in the publication
0.002
N-[4-(2,4-dimethyl-1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
Homo sapiens
-
isozyme IMPDH II IC50: 0.002 mM
0.005
N-[4-(4-methyl-1,3-oxazol-5-yl)phenyl]-5-phenyl-1,3-oxazol-2-amine
Homo sapiens
-
isozyme IMPDH II IC50: 0.005 mM
0.001
pellynic acid
Homo sapiens
-
0.000016
phenyl N'-cyano-N-(3-[cyano[3-methoxy-4-(1,3-oxazol-5-yl)phenyl]carbamimidamido]benzyl)imidocarbamate
Homo sapiens
-
0.000104
tert-butyl 7'-methoxy-3'-methyl-6'-(1,3-oxazol-5-yl)-4'-oxo-3',4'-dihydro-1H,1'H-spiro[pyrrolidine-3,2'-quinazoline]-1-carboxylate
Homo sapiens
-
IC50: 104 nM, isozyme IMPDH II
0.000035
tert-butyl methyl (1S,4S)-7'-methoxy-3'-methyl-6'-(1,3-oxazol-5-yl)-4'-oxo-3',4'-dihydro-1'H-spiro[cyclopentane-1,2'-quinazoline]-3,4-dicarboxylate
Homo sapiens
-
0.0016
tetrasodium 6,6'-[(3,3'-dimethoxy[1,1'-biphenyl]-4,4'-diyl)bis[(E)-diazene-2,1-diyl]]bis(4-amino-5-hydroxynaphthalene-1,3-disulfonate)
Pseudomonas aeruginosa
pH and temperature not specified in the publication
0.000013 - 0.00003
thiazofurin-5'-yl-2-ethyladenosin-5'-yl-difluromethylene bis(phosphonate)
0.000001 - 0.000014
thiazole-4-carboxamide 2-ethyladenine dinucleotide
0.00011
thiazole-4-carboxamide adenine dinucleotide
Homo sapiens
pH 8.0, 25°C
0.000006
VX-148
Homo sapiens
-
isozyme IMPDH II IC50: 6 nM
0.000011
VX-497
Homo sapiens
-
isozyme IMPDH II IC50: 11 nM
0.000506
[(1E,3E)-5-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-methylpenta-1,3-dien-1-yl]phosphonic acid
Homo sapiens
-
isozyme IMPDH II IC50: 506 nM
0.000168
[(2E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-methylbut-2-en-1-yl]phosphonic acid
Homo sapiens
-
isozyme IMPDH II IC50: 168 nM
0.001
[(2E)-4-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2-methylbut-2-en-1-yl]phosphoramidic acid
Homo sapiens
-
isozyme IMPDH II IC50: above 0.001 mM
0.000096
[(3E)-5-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-methylpent-3-en-1-yl]phosphonic acid
Homo sapiens
-
isozyme IMPDH II IC50: 96 nM
0.00002
[(3E)-5-(6-ethyl-4-hydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-methylpent-3-en-1-yl]phosphonic acid
Homo sapiens
-
isozyme IMPDH II IC50: 20 nM
0.000086
[(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-en-1-yl]phosphonic acid
Homo sapiens
-
isozyme IMPDH II IC50: 86 nM
additional information
additional information
Vibrio cholerae serotype O1
-
the inhibitors all exhibit inhibitory potencies with IC50 values of over 0.005 mM with wild-type and truncation mutant
-