Reference on EC 5.6.1.1 - microtubule-severing ATPase and Organism(s) Homo sapiens and UniProt Accession Q9BW62
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hartman, J.J.; Mahr, J.; McNally, K.; Okawa, K.; Iwamatsu, A.; Thomas, S.; Cheesman, S.; Heuser, J.; Vale, R.D.; McNally, F.J.
Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit
Cell
93
277-287
1998
Saccharomyces cerevisiae, Caenorhabditis elegans, Dictyostelium sp., Drosophila sp. (in: flies), Homo sapiens, Strongylocentrotus purpuratus, Xenopus laevis
Lohret, T.A.; McNally, F.J.; Quarmby, L.M.
A role for katanin-mediated axonemal severing during Chlamydomonas deflagellation
Mol. Biol.
9
1195-1207
1998
Chlamydomonas reinhardtii, Homo sapiens, Strongylocentrotus purpuratus, Xenopus laevis
McNally, F.J.; Thomas, S.
Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs
Mol. Biol.
9
1847-1861
1998
Caenorhabditis elegans, Gallus gallus, Chlamydomonas reinhardtii, Mus musculus, Strongylocentrotus purpuratus, Xenopus laevis, Homo sapiens (O75449), Homo sapiens
Lohret, T.A.; Zhao, L.; Quarmby, L.M.
Cloning of Chlamydomonas p60 katanin and localization to the site of outer doublet severing during deflagellation
Cell Motil. Cytoskeleton
43
221-231
1999
Chlamydomonas reinhardtii, Homo sapiens, Strongylocentrotus purpuratus, Xenopus laevis
Ahmad, F.J.; Yu, W.; McNally, F.J.; Baas, P.W.
An essential role for katanin in severing microtubules in the neuron
J. Cell Biol.
145
305-315
1999
Homo sapiens, Rattus norvegicus, Strongylocentrotus purpuratus
Quarmby, L.
Cellular Samurai: katanin and the severing of microtubules
J. Cell Sci.
113
2821-2827
2000
Arabidopsis sp., Caenorhabditis elegans, Chlamydomonas reinhardtii, Drosophila sp. (in: flies), Homo sapiens, no activity in Saccharomyces cerevisiae, Xenopus laevis
Buster, D.; McNally, K.; McNally, F.J.
Katanin inhibition prevents the redistribution of gamma-tubulin at mitosis
J. Cell Sci.
115
1083-1092
2002
Homo sapiens
Evans, K.J.; Gomes, E.R.; Reisenweber, S.M.; Gundersen, G.G.; Lauring, B.P.
Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing
J. Cell Biol.
168
599-606
2005
Homo sapiens
Salinas, S.; Carazo-Salas, R.E.; Proukakis, C.; Cooper, J.M.; Weston, A.E.; Schiavo, G.; Warner, T.T.
Human spastin has multiple microtubule-related functions
J. Neurochem.
95
1411-1420
2005
Homo sapiens (Q9UBP0), Homo sapiens
Schickel, J.; Beetz, C.; Froemmel, C.; Heide, G.; Sasse, A.; Hemmerich, P.; Deufel, T.
Unexpected pathogenic mechanism of a novel mutation in the coding sequence of SPG4 (spastin)
Neurology
66
421-423
2006
Homo sapiens
Evans, K.; Keller, C.; Pavur, K.; Glasgow, K.; Conn, B.; Lauring, B.
Interaction of two hereditary spastic paraplegia gene products, spastin and atlastin, suggests a common pathway for axonal maintenance
Proc. Natl. Acad. Sci. USA
103
10666-10671
2006
Homo sapiens
Luo, L.; Carson, J.D.; Molnar, K.S.; Tuske, S.J.; Coales, S.J.; Hamuro, Y.; Sung, C.M.; Sudakin, V.; Auger, K.R.; Dhanak, D.; Jackson, J.R.; Huang, P.S.; Tummino, P.J.; Copeland, R.A.
Conformation-dependent ligand regulation of ATP hydrolysis by human KSP - activation of basal hydrolysis and inhibition of microtubule-stimulated hydrolysis by a single, small molecule modulator
J. Am. Chem. Soc.
130
7584-7591
2008
Homo sapiens
White, S.R.; Evans, K.J.; Lary, J.; Cole, J.L.; Lauring, B.
Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing
J. Cell Biol.
176
995-1005
2007
Homo sapiens
Pantakani, D.V.; Swapna, L.S.; Srinivasan, N.; Mannan, A.U.
Spastin oligomerizes into a hexamer and the mutant spastin (E442Q) redistribute the wild-type spastin into filamentous microtubule
J. Neurochem.
106
613-624
2008
Homo sapiens
Salinas, S.; Carazo-Salas, R.E.; Proukakis, C.; Schiavo, G.; Warner, T.T.
Spastin and microtubules - Functions in health and disease
J. Neurosci. Res.
85
2778-2782
2007
Homo sapiens (Q9UBP0)
Mannan, A.U.; Boehm, J.; Sauter, S.M.; Rauber, A.; Byrne, P.C.; Neesen, J.; Engel, W.
Spastin, the most commonly mutated protein in hereditary spastic paraplegia interacts with Reticulon 1 an endoplasmic reticulum protein
Neurogenetics
7
93-103
2006
Homo sapiens
Matsuno, K.; Sawada, J.; Sugimoto, M.; Ogo, N.; Asai, A.
Bis(hetero)aryl derivatives as unique kinesin spindle protein inhibitors
Bioorg. Med. Chem. Lett.
19
1058-1061
2009
Homo sapiens
Mancuso, G.; Rugarli, E.I.
A cryptic promoter in the first exon of the SPG4 gene directs the synthesis of the 60-kDa spastin isoform
BMC Biol.
6
31
2008
Homo sapiens (Q9UBP0)
Connell, J.W.; Lindon, C.; Luzio, J.P.; Reid, E.
Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion
Traffic
10
42-56
2009
Homo sapiens (Q9UBP0)
Lumb, J.H.; Connell, J.W.; Allison, R.; Reid, E.
The AAA ATPase spastin links microtubule severing to membrane modelling
Biochim. Biophys. Acta
1823
192-197
2012
Homo sapiens
Eckert, T.; Link, S.; Le, D.T.; Sobczak, J.P.; Gieseke, A.; Richter, K.; Woehlke, G.
Subunit interactions and cooperativity in the microtubule-severing AAA ATPase spastin
J. Biol. Chem.
287
26278-26290
2012
Homo sapiens
Draberova, E.; Vinopal, S.; Morfini, G.; Liu, P.S.; Sladkova, V.; Sulimenko, T.; Burns, M.R.; Solowska, J.; Kulandaivel, K.; de Chadarevian, J.P.; Legido, A.; Moerk, S.J.; Janacek, J.; Baas, P.W.; Draber, P.; Katsetos, C.D.
Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation
J. Neuropathol. Exp. Neurol.
70
811-826
2011
Homo sapiens (Q9UBP0), Homo sapiens
Taylor, J.; White, S.; Lauring, B.; Kull, F.
Crystal structure of the human spastin AAA domain
J. Struct. Biol.
179
133-137
2012
Homo sapiens
Bailey, M.E.; Sackett, D.L.; Ross, J.L.
Katanin severing and binding microtubules are inhibited by tubulin carboxy tails
Biophys. J.
109
2546-2561
2015
Homo sapiens (O75449), Homo sapiens, Xenopus laevis (Q9PUL2)
Fan, X.; Lin, Z.; Fan, G.; Lu, J.; Hou, Y.; Habai, G.; Sun, L.; Yu, P.; Shen, Y.; Wen, M.; Wang, C.
The AAA protein spastin possesses two levels of basal ATPase activity
FEBS Lett.
592
1625-1633
2018
Homo sapiens (Q9UBP0)
Nithianantham, S.; McNally, F.J.; Al-Bassam, J.
Structural basis for disassembly of katanin heterododecamers
J. Biol. Chem.
293
10590-10605
2018
Caenorhabditis elegans (P34808), Homo sapiens (Q9BW62)
Cheung, K.; Senese, S.; Kuang, J.; Bui, N.; Ongpipattanakul, C.; Gholkar, A.; Cohn, W.; Capri, J.; Whitelegge, J.P.; Torres, J.Z.
Proteomic analysis of the mammalian Katanin family of microtubule-severing enzymes defines Katanin p80 subunit B-like 1 (KATNBL1) as a regulator of mammalian Katanin microtubule-severing
Mol. Cell. Proteomics
15
1658-1669
2016
Homo sapiens (Q9BW62)
