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Literature summary for 5.6.1.1 extracted from

  • Matsuno, K.; Sawada, J.; Sugimoto, M.; Ogo, N.; Asai, A.
    Bis(hetero)aryl derivatives as unique kinesin spindle protein inhibitors (2009), Bioorg. Med. Chem. Lett., 19, 1058-1061.
    View publication on PubMed
Search for more literature for 5.6.1.1

Inhibitors

Inhibitors Comment Organism Structure
1-[3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]methanamine
-
 Homo sapiens
2-(4-tert-butylphenyl)pyridine
-
 Homo sapiens
3'-fluoro-4'-(trifluoromethyl)biphenyl-4-amine
-
 Homo sapiens
3'-fluoro-4'-(trifluoromethyl)biphenyl-4-carbaldehyde
-
 Homo sapiens
3'-fluoro-4'-(trifluoromethyl)biphenyl-4-carbonitrile
-
 Homo sapiens
3'-fluoro-4'-(trifluoromethyl)biphenyl-4-ol
-
 Homo sapiens
3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl methyl sulfone
-
 Homo sapiens
3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl methyl sulfoxide
-
 Homo sapiens
3'-fluoro-N,N-dimethyl-4'-(trifluoromethyl)biphenyl-4-sulfonamide
-
 Homo sapiens
3'-fluoro-N-methyl-4'-(trifluoromethyl)biphenyl-4-sulfonamide
-
 Homo sapiens
3-(4-tert-butylphenyl)pyridine
-
 Homo sapiens
3-fluoro-4'-(methoxymethyl)-4-(trifluoromethyl)biphenyl
-
 Homo sapiens
4'-(ethylsulfonyl)-3-fluoro-4-(trifluoromethyl)biphenyl
-
 Homo sapiens
4'-(trifluoromethyl)biphenyl-4-carbonitrile
-
 Homo sapiens
4'-tert-butylbiphenyl-4-carbonitrile
-
 Homo sapiens
4-(2-tert-butylphenyl)pyridine
-
 Homo sapiens
4-(3-tert-butylphenyl)pyridine
-
 Homo sapiens
4-(4-tert-butylphenyl)pyridine
-
 Homo sapiens
methyl 3'-fluoro-4'-(trifluoromethyl)biphenyl-4-carboxylate
-
 Homo sapiens
N-[3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]methanesulfonamide
-
 Homo sapiens
N-[3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]sulfamide
-
 Homo sapiens
N-[5-[3-fluoro-4-(trifluoromethyl)phenyl]pyridin-2-yl]sulfamide
-
 Homo sapiens
N-[[3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]methyl]sulfamide
-
 Homo sapiens
PVZB1084
-
 Homo sapiens
PVZB1194 inhibition only in presence of microtubules Homo sapiens
[3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]methanol
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
kinesin spindle protein
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 value above 0.02 mM Homo sapiens 3'-fluoro-N,N-dimethyl-4'-(trifluoromethyl)biphenyl-4-sulfonamide
additional information
-
 value above 0.02 mM Homo sapiens 4'-(ethylsulfonyl)-3-fluoro-4-(trifluoromethyl)biphenyl
additional information
-
 value above 0.02 mM Homo sapiens 4-(2-tert-butylphenyl)pyridine
additional information
-
 value above 0.02 mM Homo sapiens methyl 3'-fluoro-4'-(trifluoromethyl)biphenyl-4-carboxylate
additional information
-
 value above 0.02 mM Homo sapiens 2-(4-tert-butylphenyl)pyridine
additional information
-
 value above 0.02 mM Homo sapiens 1-[3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]methanamine
0.00002
-
-
 Homo sapiens N-[3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]sulfamide
0.00004
-
-
 Homo sapiens N-[5-[3-fluoro-4-(trifluoromethyl)phenyl]pyridin-2-yl]sulfamide
0.00012
-
-
 Homo sapiens PVZB1194
0.00042
-
-
 Homo sapiens 4-(3-tert-butylphenyl)pyridine
0.0007
-
-
 Homo sapiens PVZB1084
0.00086
-
-
 Homo sapiens 3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl methyl sulfone
0.001
-
-
 Homo sapiens 4-(4-tert-butylphenyl)pyridine
0.0014
-
-
 Homo sapiens 3'-fluoro-4'-(trifluoromethyl)biphenyl-4-carbonitrile
0.00147
-
-
 Homo sapiens 3'-fluoro-4'-(trifluoromethyl)biphenyl-4-carbaldehyde
0.00147
-
-
 Homo sapiens 4'-tert-butylbiphenyl-4-carbonitrile
0.00214
-
-
 Homo sapiens 3'-fluoro-4'-(trifluoromethyl)biphenyl-4-ol
0.00247
-
-
 Homo sapiens 3'-fluoro-4'-(trifluoromethyl)biphenyl-4-amine
0.00278
-
-
 Homo sapiens N-[3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]methanesulfonamide
0.00306
-
-
 Homo sapiens N-[[3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]methyl]sulfamide
0.00363
-
-
 Homo sapiens [3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl]methanol
0.0037
-
-
 Homo sapiens 3'-fluoro-4'-(trifluoromethyl)biphenyl-4-yl methyl sulfoxide
0.00461
-
-
 Homo sapiens 3'-fluoro-N-methyl-4'-(trifluoromethyl)biphenyl-4-sulfonamide
0.00549
-
-
 Homo sapiens 4'-(trifluoromethyl)biphenyl-4-carbonitrile
0.0068
-
-
 Homo sapiens 3-(4-tert-butylphenyl)pyridine
0.00714
-
-
 Homo sapiens 3-fluoro-4'-(methoxymethyl)-4-(trifluoromethyl)biphenyl