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BRENDA support

Literature summary for 5.6.1.1 extracted from

  • Lumb, J.H.; Connell, J.W.; Allison, R.; Reid, E.
    The AAA ATPase spastin links microtubule severing to membrane modelling (2012), Biochim. Biophys. Acta, 1823, 192-197.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O microtubule breakage requires ATP hydrolysis Homo sapiens ADP + phosphate
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?

Subunits

Subunits Comment Organism
homohexamer
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Homo sapiens

Synonyms

Synonyms Comment Organism
microtuble severing AAA ATPase spastin
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Homo sapiens

General Information

General Information Comment Organism
malfunction mutations identified as a major cause of a genetic neurodegenerative condition termed hereditary spastic paraplegia Homo sapiens