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Literature summary for 5.6.1.1 extracted from

  • Bailey, M.E.; Sackett, D.L.; Ross, J.L.
    Katanin severing and binding microtubules are inhibited by tubulin carboxy tails (2015), Biophys. J., 109, 2546-2561 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
tubulin tubulin can inhibit severing activity by interfering with katanin binding to microtubules. The inhibition is mediated by the sequence of the tubulin and specifically depends on the carboxy-terminal tails. beta-Tubulin tails are the most effective at inhibiting severing, and detyrosinated alpha-tubulin tails are the least effective Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O75449 catalytic p60 subunit
-
Xenopus laevis Q9PUL2 catalytic p60 subunit
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + microtubule
-
Homo sapiens ADP + phosphate + alpha/beta tubulin heterodimers
-
?
ATP + H2O + microtubule
-
Xenopus laevis ADP + phosphate + alpha/beta tubulin heterodimers
-
?

Synonyms

Synonyms Comment Organism
katanin
-
Homo sapiens
katanin
-
Xenopus laevis