Inhibitors | Comment | Organism | Structure |
---|---|---|---|
tubulin | tubulin can inhibit severing activity by interfering with katanin binding to microtubules. The inhibition is mediated by the sequence of the tubulin and specifically depends on the carboxy-terminal tails. beta-Tubulin tails are the most effective at inhibiting severing, and detyrosinated alpha-tubulin tails are the least effective | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O75449 | catalytic p60 subunit | - |
Xenopus laevis | Q9PUL2 | catalytic p60 subunit | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + microtubule | - |
Homo sapiens | ADP + phosphate + alpha/beta tubulin heterodimers | - |
? | |
ATP + H2O + microtubule | - |
Xenopus laevis | ADP + phosphate + alpha/beta tubulin heterodimers | - |
? |
Synonyms | Comment | Organism |
---|---|---|
katanin | - |
Homo sapiens |
katanin | - |
Xenopus laevis |