Application | Comment | Organism |
---|---|---|
medicine | a major fraction of autosomal dominant cases of hereditary spastic paraplegia (HSP) is caused by mutations in SPG4 encoding spastin | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
coding sequence of spastin fused N-terminally to EGFP (pEGFP-N3 vector) | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
406-415del | localizes as wild type, but lacks microtubule severing activity | Homo sapiens |
I406V | mutant resembles wild type | Homo sapiens |
K388R | difference in localization and ability to sever microtubules | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endosome | - |
Homo sapiens | 5768 | - |
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | Homo sapiens | - |
ADP + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEp-2 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O | - |
Homo sapiens | ADP + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
spastin | - |
Homo sapiens |