Literature summary for 5.6.1.1 extracted from

Draberova, E.; Vinopal, S.; Morfini, G.; Liu, P.S.; Sladkova, V.; Sulimenko, T.; Burns, M.R.; Solowska, J.; Kulandaivel, K.; de Chadarevian, J.P.; Legido, A.; Moerk, S.J.; Janacek, J.; Baas, P.W.; Draber, P.; Katsetos, C.D.
Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation (2011), J. Neuropathol. Exp. Neurol., 70, 811-826.

Search for more literature for 5.6.1.1

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in 293T HEK cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9UBP0	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
glioblastoma cell line	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
microtuble-severing ATPase spastin	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	expression and cellular distribution are increased in neoplastic glial phenotypes, especially in glioblastoma	up

General Information

General Information	Comment	Organism
physiological function	functional experiments indicate that spastin depletion results in reduced cell motility and higher cell proliferation of glioblastoma cell line T98G cells	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)