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Literature summary for 5.6.1.1 extracted from

  • Ahmad, F.J.; Yu, W.; McNally, F.J.; Baas, P.W.
    An essential role for katanin in severing microtubules in the neuron (1999), J. Cell Biol., 145, 305-315.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Rattus norvegicus 5737
-
cytoplasm
-
Strongylocentrotus purpuratus 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60000
-
1 * 80000 + 1 * 60000, SDS-PAGE Rattus norvegicus
60000
-
1 * 80000 + 1 * 60000, SDS-PAGE Strongylocentrotus purpuratus
80000
-
1 * 80000 + 1 * 60000, SDS-PAGE Rattus norvegicus
80000
-
1 * 80000 + 1 * 60000, SDS-PAGE Strongylocentrotus purpuratus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O Homo sapiens
-
ADP + phosphate
-
?
ATP + H2O Rattus norvegicus
-
ADP + phosphate
-
?
ATP + H2O Strongylocentrotus purpuratus
-
ADP + phosphate
-
?
GTP + H2O Homo sapiens
-
GDP + phosphate
-
?
GTP + H2O Rattus norvegicus
-
GDP + phosphate
-
?
GTP + H2O Strongylocentrotus purpuratus
-
GDP + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
human
-
Rattus norvegicus
-
-
-
Strongylocentrotus purpuratus
-
sea urchin
-

Reaction

Reaction Comment Organism Reaction ID
n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome Homo sapiens
n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome Rattus norvegicus
n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome Strongylocentrotus purpuratus

Source Tissue

Source Tissue Comment Organism Textmining
egg
-
Rattus norvegicus
-
egg
-
Strongylocentrotus purpuratus
-
fibroblast
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O
-
Homo sapiens ADP + phosphate
-
?
ATP + H2O
-
Rattus norvegicus ADP + phosphate
-
?
ATP + H2O
-
Strongylocentrotus purpuratus ADP + phosphate
-
?
GTP + H2O
-
Homo sapiens GDP + phosphate
-
?
GTP + H2O
-
Rattus norvegicus GDP + phosphate
-
?
GTP + H2O
-
Strongylocentrotus purpuratus GDP + phosphate
-
?

Subunits

Subunits Comment Organism
dimer 1 * 80000 + 1 * 60000, SDS-PAGE Rattus norvegicus
dimer 1 * 80000 + 1 * 60000, SDS-PAGE Strongylocentrotus purpuratus