Reference on EC 4.6.1.2 - guanylate cyclase and Organism(s) Rattus norvegicus and UniProt Accession P16067
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Ohlstein, E.H.; Wood, K.S.; Ignarro, L.J.
Purification and properties of heme-deficient hepatic soluble guanylate cyclase: effects of heme and other factors on enzyme activation by NO, NO-heme, and protoporphyrin IX
Arch. Biochem. Biophys.
218
187-198
1982
Rattus norvegicus
Zwiller, J.; Basset, P.; Mandel, P.
Rat brain guanylate cyclase. Purification, amphiphilic properties and immunological characterization
Biochim. Biophys. Acta
658
64-75
1981
Rattus norvegicus
Spruill, W.A.; Steiner, A.L.; Earp, H.S.
Characterization of rat testicular guanylate cyclase during development
Biochim. Biophys. Acta
587
484-494
1979
Rattus norvegicus
Braughler, J.M.; Mittal, C.K.; Murad, F.
Purification of soluble guanylate cyclase from rat liver
Proc. Natl. Acad. Sci. USA
76
219-222
1979
Rattus norvegicus
Garbers, D.L.
Purification of soluble guanylate cyclase from rat lung
J. Biol. Chem.
254
240-243
1979
Rattus norvegicus
Tsai, S.C.; Manganiello, V.C.; Vaughan, M.
Purification of guanylate cyclase from rat liver supernatant
J. Biol. Chem.
253
8452-8457
1978
Rattus norvegicus
-
Nakane, M.; Deguchi, T.
Purification and properties of guanylate cyclase from the synaptosomal soluble fraction of rat brain
Biochim. Biophys. Acta
525
275-285
1978
Rattus norvegicus
Craven, P.A.; DeRubertis, F.R.
Properties and subcellular distribution of guanylate cyclase activity in rat renal medulla: correlation with tissue content of guanosine 3 ,5 -monophosphate
Biochemistry
15
5131-5137
1976
Rattus norvegicus
Neer, E.J.; Sukiennnik, E.A.
Guanylate cyclase from the rat renal medulla. Physical properties and comparison with adenylate cyclase
J. Biol. Chem.
250
7905-7909
1975
Rattus norvegicus
De Jonge, H.R.
Properties of guanylate cyclase and levels of cyclic GMP in rat small intestinal villous and crypt cells
FEBS Lett.
55
143-152
1975
Rattus norvegicus
Chrisman, T.D.; Garbers, D.L.; Parks, M.A.; Hardman, J.G.
Characterization of particulate and soluble guanylate cyclases from rat lung
J. Biol. Chem.
250
374-381
1975
Rattus norvegicus
Hardman, J.C.; Sutherland, E.W.
Guanyl cyclase, an enzyme catalyzing the formation of guanosine 3 ,5 -monophosphate from guanosine trihosphate
J. Biol. Chem.
244
6363-6370
1969
Rattus norvegicus
Hoenicka, M.; Becker, E.M.; Apeler, H.; Sirichoke, T.; Schroeder, H.; Gerzer, R.; Stasch, J.P.
Purified soluble guanylyl cyclase expressed in a baculovirus/Sf9 system: stimulation by YC-1, nitric oxide, and carbon monoxide
J. Mol. Med.
77
14-23
1999
Rattus norvegicus
Hakki, S.; Crane, M.; Hugues, M.; O'Hanley, P.; Waldman, S.A.
Solubilization and characterization of functionally coupled Escherichia coli heat-stable toxin receptors and particulate guanylate cyclase associated with the cytoskeleton compartment of intestinal membranes
Int. J. Biochem.
25
557-566
1993
Rattus norvegicus
Grabow, M.; Chakraborty, G.; Ledeen, R.W.
Characterization of guanylyl cyclase in purified myelin
Neurochem. Res.
21
457-462
1996
Rattus norvegicus
Chang, C.H.; Kohse, K.P.; Chang, B.; Hirata, M.; Jiang, B.; Douglas, J.E.; Murad, F.
Characterization of ATP-stimulated guanylate cyclase activation in rat lung membranes
Biochim. Biophys. Acta
1052
159-165
1990
Rattus norvegicus
Waldman, S.A.; Leitman, D.C.; Murad, F.
Immunoaffinity purification of soluble guanylyl cyclase
Methods Enzymol.
195
391-396
1991
Rattus norvegicus
Lamothe, M.; Chang, F.J.; Balashova, N.; Shirokov, R.; Beuve, A.
Functional Characterization of Nitric Oxide and YC-1 Activation of Soluble Guanylyl Cyclase: Structural Implication for the YC-1 Binding Site?
Biochemistry
43
3039-3048
2004
Rattus norvegicus
Rambotti, M.G.; Spreca, A.; Giambanco, I.; Sorci, G.; Donato, R.
Ultracytochemistry as a tool for the study of the cellular and subcellular localization of membrane-bound guanylate cyclase (GC) activity. Applicability to both receptor-activated and receptor-independent GC activity
Mol. Cell. Biochem.
230
85-96
2002
Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
Derbyshire, E.R.; Tran, R.; Mathies, R.A.; Marletta, M.A.
Characterization of nitrosoalkane binding and activation of soluble guanylate cyclase
Biochemistry
44
16257-16265
2005
Rattus norvegicus
Karow, D.S.; Pan, D.; Davis, J.H.; Behrends, S.; Mathies, R.A.; Marletta, M.A.
Characterization of functional heme domains from soluble guanylate cyclase
Biochemistry
44
16266-16274
2005
Rattus norvegicus
Winger, J.A.; Marletta, M.A.
Expression and characterization of the catalytic domains of soluble guanylate cyclase: interaction with the heme domain
Biochemistry
44
4083-4090
2005
Rattus norvegicus
Chang, F.J.; Lemme, S.; Sun, Q.; Sunahara, R.K.; Beuve, A.
Nitric oxide-dependent allosteric inhibitory role of a second nucleotide binding site in soluble guanylyl cyclase
J. Biol. Chem.
280
11513-11519
2005
Rattus norvegicus
Cary, S.P.; Winger, J.A.; Marletta, M.A.
Tonic and acute nitric oxide signaling through soluble guanylate cyclase is mediated by nonheme nitric oxide, ATP, and GTP
Proc. Natl. Acad. Sci. USA
102
13064-13069
2005
Rattus norvegicus
Woodard, G.E.; Zhao, J.; Rosado, J.A.
Different effect of ATP on ANP receptor guanylyl cyclase in spontaneously hypertensive and normotensive rats
Acta Physiol. (Oxf.)
188
195-206
2006
Rattus norvegicus
Belik, J.; Hehne, N.; Pan, J.; Behrends, S.
Soluble guanylate cyclase-dependent relaxation is reduced in the adult rat bronchial smooth muscle
Am. J. Physiol. Lung Cell Mol. Physiol.
292
L699-L703
2007
Rattus norvegicus
Duda, T.; Sharma, R.K.
ONE-GC membrane guanylate cyclase, a trimodal odorant signal transducer
Biochem. Biophys. Res. Commun.
367
440-445
2008
Rattus norvegicus
Ro, J.Y.; Lee, J.; Capra, N.F.; Zhang, Y.
Role of soluble guanylate cyclase in the trigeminal subnucleus caudalis in capsaicin-induced muscle hypersensitivity
Brain Res.
1184
141-148
2007
Rattus norvegicus
Poulos, T.L.
Soluble guanylate cyclase
Curr. Opin. Struct. Biol.
16
736-743
2006
Bos taurus, Clostridium botulinum, Homo sapiens, Rattus norvegicus, Caldanaerobacter subterraneus subsp. tengcongensis, Vibrio cholerae serotype O1
Mueller, D.; Cortes-Dericks, L.; Budnik, L.T.; Brunswig-Spickenheier, B.; Pancratius, M.; Speth, R.C.; Mukhopadhyay, A.K.; Middendorff, R.
Homologous and lysophosphatidic acid-induced desensitization of the atrial natriuretic peptide receptor, guanylyl cyclase-A, in MA-10 leydig cells
Endocrinology
147
2974-2985
2006
Mus musculus, Rattus norvegicus
Winger, J.A.; Derbyshire, E.R.; Marletta, M.A.
Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs
J. Biol. Chem.
282
897-907
2007
Rattus norvegicus
Ding, J.D.; Weinberg, R.J.
Localization of soluble guanylyl cyclase in the superficial dorsal horn
J. Comp. Neurol.
495
668-678
2006
Rattus norvegicus
Pifarre, P.; Garcia, A.; Mengod, G.
Species differences in the localization of soluble guanylyl cyclase subunits in monkey and rat brain
J. Comp. Neurol.
500
942-957
2007
Macaca fascicularis, Rattus norvegicus
Ding, J.D.; Weinberg, R.J.
Distribution of soluble guanylyl cyclase in rat retina
J. Comp. Neurol.
502
734-745
2007
Rattus norvegicus
Rothkegel, C.; Schmidt, P.M.; Atkins, D.J.; Hoffmann, L.S.; Schmidt, H.H.; Schroeder, H.; Stasch, J.P.
Dimerization region of soluble guanylate cyclase characterized by bimolecular fluorescence complementation in vivo
Mol. Pharmacol.
72
1181-1190
2007
Rattus norvegicus
Hodson, C.A.; Ambrogi, I.G.; Scott, R.O.; Mohler, P.J.; Milgram, S.L.
Polarized apical sorting of guanylyl cyclase C is specified by a cytosolic signal
Traffic
7
456-464
2006
Rattus norvegicus
Cabilla, J.P.; Ronchetti, S.A.; Nudler, S.I.; Miler, E.A.; Quinteros, F.A.; Duvilanski, B.H.
Nitric oxide sensitive-guanylyl cyclase subunits expression changes during estrous cycle in anterior pituitary glands
Am. J. Physiol. Endocrinol. Metab.
296
731-737
2009
Rattus norvegicus
Jebelovszki, E.; Kiraly, C.; Erdei, N.; Feher, A.; Pasztor, E.T.; Rutkai, I.; Forster, T.; Edes, I.; Koller, A.; Bagi, Z.
High-fat diet-induced obesity leads to increased NO sensitivity of rat coronary arterioles: role of soluble guanylate cyclase activation
Am. J. Physiol. Heart Circ. Physiol.
294
H2558-H2564
2008
Rattus norvegicus
Zhou, Z.; Sayed, N.; Pyriochou, A.; Roussos, C.; Fulton, D.; Beuve, A.; Papapetropoulos, A.
Protein kinase G phosphorylates soluble guanylyl cyclase on serine 64 and inhibits its activity
Arterioscler. Thromb. Vasc. Biol.
28
1803-1810
2008
Rattus norvegicus
Knorr, A.; Hirth-Dietrich, C.; Alonso-Alija, C.; Haerter, M.; Hahn, M.; Keim, Y.; Wunder, F.; Stasch, J.P.
Nitric oxide-independent activation of soluble guanylate cyclase by BAY 60-2770 in experimental liver fibrosis
Arzneimittelforschung
58
71-80
2008
Rattus norvegicus
Derbyshire, E.R.; Gunn, A.; Ibrahim, M.; Spiro, T.G.; Britt, R.D.; Marletta, M.A.
Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes
Biochemistry
47
3892-3899
2008
Rattus norvegicus
Coffey, M.J.; Phare, S.M.; Luo, M.; Peters-Golden, M.
Guanylyl cyclase and protein kinase G mediate nitric oxide suppression of 5-lipoxygenase metabolism in rat alveolar macrophages
Biochim. Biophys. Acta
1781
299-305
2008
Rattus norvegicus
El-Awady, M.S.; Smirnov, S.V.; Watson, M.L.
Desensitization of the soluble guanylyl cyclase/cGMP pathway by lipopolysaccharide in rat isolated pulmonary artery but not aorta
Br. J. Pharmacol.
155
1164-1173
2008
Rattus norvegicus
Hoenicka, M.; Schmid, C.
Cardiovascular effects of modulators of soluble guanylyl cyclase activity
Cardiovasc. Hematol. Agents Med. Chem.
6
287-301
2008
Bos taurus, Canis lupus familiaris, Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa, Ovis aries (Q8SPV3)
Ruiz-Torres, M.P.; Griera, M.; Chamorro, A.; Diez-Marques, M.L.; Rodriguez-Puyol, D.; Rodriguez-Puyol, M.
Tirofiban increases soluble guanylate cyclase in rat vascular walls: pharmacological and pathophysiological consequences
Cardiovasc. Res.
82
125-132
2009
Rattus norvegicus
Schermuly, R.T.; Stasch, J.P.; Pullamsetti, S.S.; Middendorff, R.; Mueller, D.; Schlueter, K.D.; Dingendorf, A.; Hackemack, S.; Kolosionek, E.; Kaulen, C.; Dumitrascu, R.; Weissmann, N.; Mittendorf, J.; Klepetko, W.; Seeger, W.; Ghofrani, H.A.; Grimminger, F.
Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension
Eur. Respir. J.
32
881-891
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Bolin, C.; Cardozo-Pelaez, F.
Characterization of oxidized guanosine 5-triphosphate as a viable inhibitor of soluble guanylyl cyclase
Free Radic. Biol. Med.
46
828-835
2009
Bos taurus, Rattus norvegicus
Powers-Martin, K.; Barron, A.M.; Auckland, C.H.; McCooke, J.K.; McKitrick, D.J.; Arnolda, L.F.; Phillips, J.K.
Immunohistochemical assessment of cyclic guanosine monophosphate (cGMP) and soluble guanylate cyclase (sGC) within the rostral ventrolateral medulla
J. Biomed. Sci.
15
801-812
2008
Rattus norvegicus
Fusi, F.; Ferrara, A.; Koorbanally, C.; Crouch, N.R.; Mulholland, D.A.; Sgaragli, G.
Vascular myorelaxing activity of isolates from South African Hyacinthaceae partly mediated by activation of soluble guanylyl cyclase in rat aortic ring preparations
J. Pharm. Pharmacol.
60
489-497
2008
Rattus norvegicus
Fernandes, D.; de Sordi, R.; Pacheco, L.K.; Nardi, G.M.; Heckert, B.T.; Villela, C.G.; Lobo, A.R.; Barja-Fidalgo, C.; Assreuy, J.
Late but not early inhibition of soluble guanylate cyclase decreases mortality in a rat sepsis model
J. Pharmacol. Exp. Ther.
328
991-999
2008
Rattus norvegicus (P19686), Rattus norvegicus (Q80WY4)
Alzoubi, K.H.; Alkadhi, K.A.
Calmodulin and guanylyl cyclase inhibitors block the in vivo expression of gLTP in sympathetic ganglia from chronically stressed rats
Neurosci. Res.
63
95-99
2009
Rattus norvegicus
Abdelalim, E.M.; Masuda, C.; Tooyama, I.
Expression of natriuretic peptide-activated guanylate cyclases by cholinergic and dopaminergic amacrine cells of the rat retina
Peptides
29
622-628
2008
Rattus norvegicus (P16067), Rattus norvegicus (P18910)
Vanneste, G.; Van Nassauw, L.; Kalfin, R.; Van Colen, I.; Elinck, E.; Van Crombruggen, K.; Timmermans, J.P.; Lefebvre, R.A.
Jejunal cholinergic, nitrergic, and soluble guanylate cyclase activity in postoperative ileus
Surgery
144
410-426
2008
Rattus norvegicus (Q02108), Rattus norvegicus (Q02153)
Murphy, B.A.; Fakira, K.A.; Song, Z.; Beuve, A.; Routh, V.H.
AMP-activated protein kinase and nitric oxide regulate the glucose sensitivity of ventromedial hypothalamic glucose-inhibited neurons
Am. J. Physiol. Cell Physiol.
297
C750-C758
2009
Rattus norvegicus
Spyridonidou, K.; Fousteris, M.; Antonia, M.; Chatzianastasiou, A.; Papapetropoulos, A.; Nikolaropoulos, S.
Tricyclic indole and dihydroindole derivatives as new inhibitors of soluble guanylate cyclase
Bioorg. Med. Chem. Lett.
19
4810-4813
2009
Rattus norvegicus
von Wantoch Rekowski, M.; Pyriochou, A.; Papapetropoulos, N.; Stoessel, A.; Papapetropoulos, A.; Giannis, A.
Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of soluble guanylyl cyclase
Bioorg. Med. Chem.
18
1288-1296
2010
Rattus norvegicus
Ma, X.; Beuve, A.; van den Akker, F.
Crystal structure of the signaling helix coiled-coil domain of the beta1 subunit of the soluble guanylyl cyclase
BMC Struct. Biol.
10
2-2
2010
Rattus norvegicus (P20595)
Haase, N.; Haase, T.; Kraehling, J.R.; Behrends, S.
Direct fusion of subunits of heterodimeric nitric oxide sensitive guanylyl cyclase leads to functional enzymes with preserved biochemical properties: evidence for isoform specific activation by ciguates
Biochem. Pharmacol.
80
1676-1683
2010
Rattus norvegicus
Baskaran, P.; Heckler, E.J.; van den Akker, F.; Beuve, A.
Aspartate 102 in the heme domain of soluble guanylyl cyclase has a key role in NO activation
Biochemistry
50
4291-4297
2011
Rattus norvegicus
Shpakov, A.; Derkach, K.; Chistyakova, O.; Pertseva, M.
Changes in the functional activity of membrane-bound guanylate cyclase forms in tissues of diabetic rats
Dokl. Biochem. Biophys.
433
219-222
2010
Rattus norvegicus
Baskaran, P.; Heckler, E.J.; van den Akker, F.; Beuve, A.
Identification of residues in the heme domain of soluble guanylyl cyclase that are important for basal and stimulated catalytic activity
PLoS ONE
6
e26976
2011
Rattus norvegicus (P20595)