Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ataciguat | HMR 1766 | Rattus norvegicus | |
cinaciguat | BAY 58-2667 | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expressed in Sf9 insect cells | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
nitric oxide | - |
Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
70400 | - |
1 * 78600 + 1 * 70400, calculated from amino acid sequence | Rattus norvegicus |
72000 | - |
1 * 80000 + 1 * 72000, SDS-PAGE | Rattus norvegicus |
78600 | - |
1 * 78600 + 1 * 70400, calculated from amino acid sequence | Rattus norvegicus |
80000 | - |
1 * 80000 + 1 * 72000, SDS-PAGE | Rattus norvegicus |
150000 | - |
gel filtration | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Strep-Tactin1 Superflow column chromatography, Mono Q column chromatography | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Rattus norvegicus | 3',5'-cyclic-GMP + diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterodimer | 1 * 78600 + 1 * 70400, calculated from amino acid sequence | Rattus norvegicus |
heterodimer | 1 * 80000 + 1 * 72000, SDS-PAGE | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
nitric oxide sensitive guanylyl cyclase | - |
Rattus norvegicus |
NO sensitive guanylyl cyclase | - |
Rattus norvegicus |
NOsGC | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | nitric oxide sensitive guanylyl cyclase is the major physiological receptor for nitric oxide throughout the cardiovascular and central nervous system | Rattus norvegicus |