Activating Compound | Comment | Organism | Structure |
---|---|---|---|
atrial natriuretic peptide | highly effective in stimulating cGMP production in MA-10 cells | Mus musculus | |
atrial natriuretic peptide | increases cGMP production up to 300fold | Rattus norvegicus | |
brain natriuretic peptide | highly effective in stimulating cGMP production in MA-10 cells | Mus musculus | |
additional information | C-type natriuretic peptide does not stimulate cGMP production | Mus musculus | |
additional information | C-type natriuretic peptide does not stimulate cGMP production | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
additional information | coexistence of homologous and heterologous desensitization of GC-A in the same cell type, these reactions are mediated by different pathways, cross talk between phospholipid and natriuretic peptide signaling | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
atrial natriuretic peptide | elicits GC-A desensitization, can induce decreased GC-A activity in MA-10 Leydig cells, based on mechanisms directly affecting the hormone responsiveness of the receptor. Protein kinase A blocks homologous atrial natriuretic peptide induced desensitization, in which cGMP is generated as second messenger | Mus musculus | |
lysophosphatidic acid | preincubations for 30 min before assessments of atrial natriuretic peptide-induced cGMP generation reveals inhibitory effects, exerted in a dose-dependent manner, elicits GC-A desensitization, protein kinase A does not block lysophosphatidic acid-induced heterologous desensitization. MEK inhibitor PD 98059 does not protect against the lysophosphatidic acid-mediated decrease in GC-A hormone sensitivity | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
alphaT3-1 cell | - |
Mus musculus | - |
brain | - |
Rattus norvegicus | - |
Leydig cell | - |
Rattus norvegicus | - |
MA-10 cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? | |
GTP | - |
Rattus norvegicus | 3',5'-cyclic GMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GC-A | - |
Mus musculus |
GC-A | - |
Rattus norvegicus |