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Information on EC 3.4.19.3 - pyroglutamyl-peptidase I
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3.4.19.3 pyroglutamyl-peptidase ISpecify your search results
Word Map
- 3.4.19.3
- trh
- lymphocyte
- thymocytes
-
thyrotropin-releasing
- cd8
- thyrotropin
-
trh-degrading
- amyloliquefaciens
-
deblocked
- analysis
- thyroliberin
- his-pro
-
diketopiperazine
-
l-pyroglutamic
- phytolacca
- hermes
-
pancreatitis-associated
-
adipokinetic
- litoralis
-
post-proline
- protein-i
-
cyclo
-
3.4.21.26
- luliberin
-
intrathymic
- medicine
The enzyme appears in viruses and cellular organisms
Reaction Schemes
release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro
Synonyms
pgp-1, pap-i, pyroglutamate aminopeptidase, pyroglutamyl aminopeptidase, pyroglutamyl peptidase i, pcp-0sh, pyrase, pyrrolidone carboxyl peptidase, pyrrolidonyl arylamidase, pyroglutamyl aminopeptidase i, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
5-oxoprolyl-peptidase
-
-
-
-
aminopeptidase, pyroglutamate
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-
-
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EC 3.4.11.8
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-
formerly
-
L-pyrrolidonecarboxylate peptidase
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-
-
-
PAP-I
PCP
PYR
pyroglutamate aminopeptidase
pyroglutamidase
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-
-
-
pyroglutamyl aminopeptidase
pyroglutamyl aminopeptidase I
pyrrolidone carboxyl peptidase
pyrrolidone-carboxylate peptidase
pyrrolidonecarboxy peptidase
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-
-
-
pyrrolidonecarboxylyl peptidase
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-
-
-
pyrrolidonyl arylamidase
pyrrolidonyl peptidase
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-
-
-
PYR
no activity in Staphylococcus aureus ATCC 25923
-
-
-
PYR
no activity in Staphylococcus pseudintermedius LMG 22219T
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-
-
pyroglutamate aminopeptidase
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-
-
-
pyroglutamyl aminopeptidase
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-
-
-
pyrrolidone-carboxylate peptidase
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-
-
-
pyrrolidonyl arylamidase
no activity in Staphylococcus aureus ATCC 25923
-
-
-
pyrrolidonyl arylamidase
no activity in Staphylococcus pseudintermedius LMG 22219T
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro
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-
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of peptide bond
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-
-
-
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PATHWAY SOURCE
PATHWAYS
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-
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CAS REGISTRY NUMBER
COMMENTARY
9075-21-2
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide + H2O
L-2-oxothiazolidine-4-carboxylic acid + ?
ACE inhibitor + H2O
pyroglutamate + ?
contains the N-terminal dipeptide pyroglutamyl-Trp-
-
?
bombesin + H2O
pyroglutamate + ?
contains the N-terminal dipeptide pyroglutamyl-Arg-
-
?
bradykinin potentiator B + H2O
pyroglutamate + ?
contains the N-terminal dipeptide pyroglutamyl-Gly-
-
?
bradykinin-potentiating peptide B + H2O
?
-
cleavage of the peptide bond adjacent to the pyroglutamic residue
-
-
?
gonadotropin-releasing hormone + H2O
?
hydrolyzed exclusively at the pyroglutamyl-/-Xaa bond
-
-
?
L-pyroglutamic acid 2-naphthylamide + H2O
L-pyroglutamate + 2-naphthylamine
-
-
-
-
?
L-pyroglutamyl p-nitroanilide + H2O
L-pyroglutamate + p-nitroaniline
-
-
-
-
?
L-pyroglutamyl-7-amido-4-methylcoumarin + H2O
L-pyroglutamate + 7-amino-4-methylcoumarin
-
-
-
?
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + 2-naphtylamine
-
-
-
-
?
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + beta-naphtylamine
-
-
-
-
?
L-pyroglutamyl-His-Pro-4-methylcoumarin 7-amide + H2O
L-pyroglutamate + His-Pro-4-methylcoumarin 7-amide
-
-
-
-
?
L-pyroglutamyl-p-nitroanilide + H2O
L-pyroglutaminic acid + p-nitroaniline
-
-
-
?
L-pyrrolidonyl 2-naphthylamide + H2O
5-oxo-L-proline + 2-naphthylamine
-
-
-
-
?
leukopyrokinin + H2O
pyroglutamate + ?
contains the N-terminal dipeptide pyroglutamyl-Thr-
-
?
luteinizing hormone releasing hormone + H2O
pyroglutamate + ?
contains the N-terminal dipeptide pyroglutamyl-His-
-
?
N-(4-methyl-2-oxo-2H-chromen-7-yl)-5-oxo-L-prolinamide + H2O
5-oxo-L-proline + 7-amino-4-methylcoumarin
-
-
-
-
?
neurotensin + H2O
pyroglutamate + ?
contains the N-terminal dipeptide pyroglutamyl-Leu-
-
?
pyroglutamic acid-7-amido-4-methylcoumarin + H2O
L-pyroglutamate + 7-amino-4-methylcoumarin
-
-
-
-
?
pyroglutamyl-2-naphthylamide + H2O
pyroglutamate + 2-naphthylamine
-
-
-
-
?
pyroglutamyl-4-methylcoumaryl-7-amide + H2O
pyroglutamate + 7-amino-4-methylcoumarin
-
-
?
pyroglutamyl-peptide + H2O
pyroglutamate + peptide
-
the enzyme is able to specifically remove the amino-terminal pyroglutamyl residue protecting proteins or peptides from aminopeptidases
-
?
4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide + H2O
L-2-oxothiazolidine-4-carboxylic acid + ?
-
-
-
-
?
4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide + H2O
L-2-oxothiazolidine-4-carboxylic acid + ?
-
-
-
-
?
4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide + H2O
L-2-oxothiazolidine-4-carboxylic acid + ?
-
-
-
-
?
acid-thyroliberin + H2O
pyroglutamate + His-Pro
-
i.e. pyroglutamyl-His-Pro
-
?
bombesin + H2O
pyroglutamate + Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
-
-
-
-
?
bombesin + H2O
pyroglutamate + Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
-
i.e. pyroglutamyl-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
-
?
ethyl L-pyroglutamate + H2O
L-pyroglutamate + ethanol
-
-
-
?
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + 2-naphthylamine
-
-
-
?
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + 2-naphthylamine
-
-
-
?
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + beta-naphthylamine
-
-
-
?
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + beta-naphthylamine
-
-
-
?
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + beta-naphthylamine
-
-
-
?
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + beta-naphthylamine
-
-
-
?
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + beta-naphthylamine
-
-
-
?
L-pyroglutamyl-p-nitroanilide + H2O
L-pyroglutamate + p-nitroaniline
-
-
-
?
L-pyroglutamyl-p-nitroanilide + H2O
L-pyroglutamate + p-nitroaniline
-
-
-
-
?
L-pyroglutamyl-p-nitroanilide + H2O
L-pyroglutamate + p-nitroaniline
-
-
-
?
L-pyroglutamyl-p-nitroanilide + H2O
L-pyroglutamate + p-nitroaniline
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-
-
?
L-pyroglutamyl-p-nitroanilide + H2O
L-pyroglutamate + p-nitroaniline
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-
-
?
litorin + H2O
pyroglutamate + Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2
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frog litorin
-
?
litorin + H2O
pyroglutamate + Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2
-
frog litorin
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?
luliberin + H2O
pyroglutamate + His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
-
i.e. pyroglutamyl-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
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?
luliberin + H2O
pyroglutamate + His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
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-
-
-
?
neurotensin + H2O
pyroglutamate + Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu
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-
-
-
?
neurotensin + H2O
pyroglutamate + Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu
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-
-
-
?
neurotensin + H2O
pyroglutamate + Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu
-
i.e. pyroglutamyl-Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu
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?
neurotensin + H2O
pyroglutamate + Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu
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-
-
-
?
neurotensin + H2O
pyroglutamate + Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu
-
-
-
-
?
physalaemin + H2O
pyroglutamate + Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2
-
-
-
?
physalaemin + H2O
pyroglutamate + Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2
-
-
-
?
pyroglutamyl-4-methylcoumarin 7-amide + H2O
pyroglutamate + 7-amino-4-methylcoumarin
-
-
-
-
?
pyroglutamyl-4-methylcoumarin 7-amide + H2O
pyroglutamate + 7-amino-4-methylcoumarin
-
-
-
-
?
pyroglutamyl-4-methylcoumarin 7-amide + H2O
pyroglutamate + 7-amino-4-methylcoumarin
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
no activity in Staphylococcus aureus
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
no activity in Staphylococcus aureus ATCC 25923
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
no activity in Staphylococcus pseudintermedius
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
no activity in Staphylococcus pseudintermedius LMG 22219T
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
Staphylococcus delphini 49-046
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
Staphylococcus delphini 52-006
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
Staphylococcus delphini 53-033
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
Staphylococcus delphini 56-021
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
Staphylococcus delphini 56-039
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
Staphylococcus delphini 62-031
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
Staphylococcus delphini MI 09-2894
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
Staphylococcus delphini MI 09-8445
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
Staphylococcus delphini MI 16-1129
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
Staphylococcus delphini VPP 12 D
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
Staphylococcus pseudintermedius LMG 22219T
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
-
-
-
-
?
pyroglutamyl-His-Gly + H2O
pyroglutamate + His-Gly
-
i.e. anorexogenic peptide
-
?
pyroglutamyl-p-nitroanilide + H2O
pyroglutamate + p-nitroaniline
-
-
-
-
?
thyroliberin + H2O
pyroglutamate + His-Pro-NH2
-
removes the N-terminal pyroglutamic acid
-
-
?
thyroliberin + H2O
pyroglutamate + His-Pro-NH2
-
i.e. pyroglutamyl-His-Pro-NH2, i.e. thyrotrophin releasing hormone
-
?
thyrotrophin releasing hormone
?
-
the enzyme is proposed to inactivate thyrotrophin releasing hormone in brain extracellular space
-
-
?