Activating Compound | Comment | Organism | Structure |
---|---|---|---|
glucose | alters the hypothalamic activity of soluble PAP-I | Rattus norvegicus | |
Insulin | alters the hypothalamic activity of soluble PAP-I | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
medicine | diabetes mellitus affects the levels of hippocampal and hypothalamic PAP-I activities, which may change the metabolic control of its susceptible physiological peptide substrates in the brain | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
amastatin | inhibits soluble PAP-I in the hippocampus by 12.5% and in the hypothalamus by 13.8%. Does not inhibit membrane-bound PAP-I | Rattus norvegicus | |
bestatin | inhibits soluble PAP-I in the hippocampus by 14.8% and in the hypothalamus by 14.4%. Inhibition of membrane-bound PAP-I in the hypothalamus by 8.8% | Rattus norvegicus | |
additional information | not inhibited by phenyl methyl sulphonyl fluoride. 28% reduced activity of soluble PAP-I and 40-45% reduced activity of membrane-bound PAP-I in both the hippocampus and hypothalamus of streptozotocin-diabetic rats. Changes can be mitigated by concomitant treatment with insulin | Rattus norvegicus | |
puromycin | inhibits soluble PAP-I in the hippocampus by 15.5% and in the hypothalamus by 42.5%. Inhibition of membrane-bound PAP-I in the hippcampus by 11.5% | Rattus norvegicus | |
Zn2+ | inhibits soluble PAP-1 in the hippocampus and hypothalamus, does not inhibit membrane-bound PAP-I | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Rattus norvegicus | 16020 | - |
soluble | - |
Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Wistar rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
hippocampus | - |
Rattus norvegicus | - |
hypothalamus | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
PAP-I | - |
Rattus norvegicus |
pyroglutamyl type I aminopeptidase | - |
Rattus norvegicus |