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Literature summary for 3.4.19.3 extracted from
- Marginal involvement of pyroglutamyl aminopeptidase I in metabolism of thyrotropin-releasing hormone in rat brain (2004), Biol. Pharm. Bull., 27, 1197-1201.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.038 | - |
L-pyroglutamyl-p-nitroanilide | 37°C, pH 7.4 | Homo sapiens |  |
| 0.038 | - |
L-pyroglutamyl-p-nitroanilide | 37°C, pH 7.4 | Mus musculus | |
| 0.041 | - |
thyrotropin-releasing hormone | 37°C, pH 7.4 | Mus musculus | |
| 0.046 | - |
thyrotropin-releasing hormone | 37°C, pH 7.4 | Homo sapiens | |
| 0.054 | - |
L-pyroglutamyl-p-nitroanilide | 37°C, pH 7.4 | Rattus norvegicus | |
| 0.056 | - |
thyrotropin-releasing hormone | 37°C, pH 7.4 | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | the enzyme might not be dominantly involved in the degradation of thyrotropin-releasing hormone in rats | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9NXJ5 | recombinant | - |
| Mus musculus | Q9ESW8 | recombinant | - |
| Rattus norvegicus | Q76IC5 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| renal proximal tubule | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-pyroglutamyl-p-nitroanilide + H2O | - |
Homo sapiens | L-pyroglutamate + p-nitroaniline | - |
? | |
| L-pyroglutamyl-p-nitroanilide + H2O | - |
Mus musculus | L-pyroglutamate + p-nitroaniline | - |
? | |
| L-pyroglutamyl-p-nitroanilide + H2O | - |
Rattus norvegicus | L-pyroglutamate + p-nitroaniline | - |
? | |
| additional information | the enzyme might not be dominantly involved in the degradation of thyrotropin-releasing hormone in rats | Rattus norvegicus | ? | - |
? | |
| thyrotropin-releasing hormone + H2O | - |
Homo sapiens | ? | - |
? | |
| thyrotropin-releasing hormone + H2O | - |
Mus musculus | ? | - |
? | |
| thyrotropin-releasing hormone + H2O | - |
Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PAP-I | - |
Homo sapiens |
| PAP-I | - |
Mus musculus |
| PAP-I | - |
Rattus norvegicus |
| pyroglutamyl aminopeptidase I | - |
Homo sapiens |
| pyroglutamyl aminopeptidase I | - |
Mus musculus |
| pyroglutamyl aminopeptidase I | - |
Rattus norvegicus |
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