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Literature summary for 3.4.19.3 extracted from
- Pyroglutamate aminopeptidase in rat submaxillary gland (1992), Indian J. Biochem. Biophys., 29, 442-444.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | stimulates | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| acetamide | - |
Rattus norvegicus | |
| Cu2+ | strong, even at 0.5 mM | Rattus norvegicus | |
| EDTA | 95% stimulation at pH 8.0, no effect at pH 6.5 | Rattus norvegicus | |
| Fe3+ | 0.5 mM, strong | Rattus norvegicus | |
| Zn2+ | strong, even at 0.5 mM | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| submandibular gland | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyroglutamyl-beta-naphthylamide + H2O | - |
Rattus norvegicus | pyroglutamate + beta-naphthylamine | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5 | 8 | about 40% of maximal activity at pH 5.0 and at pH 8.0 | Rattus norvegicus |
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