Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dithiothreitol | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | particulate form shows lower activity levels than the soluble form | Rattus norvegicus | - |
- |
soluble | - |
Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adult | - |
Rattus norvegicus | - |
brain | in the cortex, activity of soluble PGP I and particulate PGP I decreases 5fold and 4fold, respectively, from the embryo to the adult | Rattus norvegicus | - |
embryo | - |
Rattus norvegicus | - |
heart | high levels of of soluble PGP I activity during the initial moments of development, in the fourth postnatal day activity starts to decrease until adulthood. Activity of the particulate form shows lowest values, during the first 20 days of life a significant decrease takes place, from this moment activity remains constant. No significant changes in activity of the particulate form | Rattus norvegicus | - |
kidney | highest levels of soluble PGP I in all developmental stages, significant increase until 4 postnatal days, afterwards activity decreases slowly until 15 postnatal days, but subsequently continues to increase until 30 postnatal days. Activity of the particulate form increases until parturition day, until adulthood it remains constant with a small increase after 30 postnatal days | Rattus norvegicus | - |
liver | activity of soluble PGP I does not change significantly until 20 postnatal days, significant increase between 20-30 postnatal days. Significant decrease in the activity of the particulate form from embryonic day 22 to the fourth postnatal day, until 90 postnatal days activity remains constant | Rattus norvegicus | - |
lung | high activity of soluble PGP I during the first days of development, between 20-30 postnatal days activity decreases significantly | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-pyroglutamyl-beta-naphthylamide + H2O | - |
Rattus norvegicus | L-pyroglutamate + beta-naphtylamine | - |
? | |
thyrotropin-releasing hormone + H2O | - |
Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PGP I | - |
Rattus norvegicus |
pyroglutamyl peptidase I | - |
Rattus norvegicus |