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Literature summary for 3.4.19.3 extracted from

  • Agirregoitia, N.; Casis, L.; Gil, J.; Ruiz, F.; Irazusta, J.
    Ontogeny of prolyl endopeptidase and pyroglutamyl peptidase I in rat tissues (2007), Regul. Pept., 139, 52-58.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
dithiothreitol
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information particulate form shows lower activity levels than the soluble form Rattus norvegicus
-
-
soluble
-
Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
adult
-
Rattus norvegicus
-
brain in the cortex, activity of soluble PGP I and particulate PGP I decreases 5fold and 4fold, respectively, from the embryo to the adult Rattus norvegicus
-
embryo
-
Rattus norvegicus
-
heart high levels of of soluble PGP I activity during the initial moments of development, in the fourth postnatal day activity starts to decrease until adulthood. Activity of the particulate form shows lowest values, during the first 20 days of life a significant decrease takes place, from this moment activity remains constant. No significant changes in activity of the particulate form Rattus norvegicus
-
kidney highest levels of soluble PGP I in all developmental stages, significant increase until 4 postnatal days, afterwards activity decreases slowly until 15 postnatal days, but subsequently continues to increase until 30 postnatal days. Activity of the particulate form increases until parturition day, until adulthood it remains constant with a small increase after 30 postnatal days Rattus norvegicus
-
liver activity of soluble PGP I does not change significantly until 20 postnatal days, significant increase between 20-30 postnatal days. Significant decrease in the activity of the particulate form from embryonic day 22 to the fourth postnatal day, until 90 postnatal days activity remains constant Rattus norvegicus
-
lung high activity of soluble PGP I during the first days of development, between 20-30 postnatal days activity decreases significantly Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-pyroglutamyl-beta-naphthylamide + H2O
-
Rattus norvegicus L-pyroglutamate + beta-naphtylamine
-
?
thyrotropin-releasing hormone + H2O
-
Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
PGP I
-
Rattus norvegicus
pyroglutamyl peptidase I
-
Rattus norvegicus