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Literature summary for 3.4.19.3 extracted from

  • Marinho, C.E.; Olivo, R.d.o.A.; Zambotti-Villela, L.; Ribeiro-de-Andrade, T.N.; Fernandes, C.M.; Silveira, P.F.
    Renal and macrophage aminopeptidase activities in cyclosporin-treated mice (2006), Int. Immunopharmacol., 6, 415-425.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cyclosporin increases particulate and soluble PAP activity in the renal cortex. Particulate PAP activity returns to levels similar to controls after 15 days of cyclosporin withdrawal, soluble PAP does not regress. Soluble and particulate aminopeptidases in resident and elicited macrophages are unaffected by cyclosporin Mus musculus

Application

Application Comment Organism
medicine profiles of macrophage and renal PAP activities may be considered into the elaboration of new potential strategies for preventing nephrotoxicity during cyclosporin treatment Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
male Swiss strain mice
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
Mus musculus
-
renal cortex
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
PAP
-
Mus musculus
pyroglutamyl aminopeptidase
-
Mus musculus