Reference on EC 3.4.19.12 - ubiquitinyl hydrolase 1 and Organism(s) Homo sapiens and UniProt Accession Q92560
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wilkinson, K.D.
Ubiquitin C-terminal hydroase
Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press
660-663
1998
Bos taurus, Drosophila melanogaster, Homo sapiens, Rattus norvegicus
-
Johnston, S.C.; Larsen, C.N.; Cook, W.J.; Wilkinson, K.D.; Hill, C.P.
Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution
EMBO J.
16
3787-3796
1997
Homo sapiens
Lowe, J.; McDermott, H.; Landon, M.; Mayer, R.J.; Wilkinson, K.D.
Ubiquitin carboxyl-terminal hydrolase (PGP9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases
J. Pathol.
161
153-160
1990
Homo sapiens
Moskovitz, J.
Characterization of the 30-kDa enzyme from red blood cells that cleaves ubiquitin-protein conjugates
Biochem. Biophys. Res. Commun.
205
354-360
1994
Bos taurus, Homo sapiens
Pickart, C.M.; Rose, I.A.
Ubiquitin carboxyl-terminal hydrolase acts on ubiquitin carboxyl-terminal amides
J. Biol. Chem.
260
7903-7910
1985
Homo sapiens
Larsen, C.N.; Price, J.S.; Wilkinson, K.D.
Substrate binding and catalysis by ubiquitin C-terminal hydrolases: identification of two active site residues
Biochemistry
35
6735-6744
1996
Bos taurus, Homo sapiens, Mammalia, Rattus norvegicus
Larsen, C.N.; Krantz, B.A.; Wilkinson, K.D.
Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases
Biochemistry
37
3358-3368
1998
Homo sapiens
Falquet, L.; Paquet, N.; Frutiger, S.; Hughes, G.J.; Hoang-Van, K.; Jaton, J.C.
A human de-ubiquitinating enzyme with both isopeptidase and peptidase activities in vitro
FEBS Lett.
359
73-77
1995
Homo sapiens
Naviglio, S.; Mattecucci, C.; Matoskova, B.; Nagase, T.; Nomura, N.; Di Fiore, P.P.; Draetta, G.F.
UBPY: a growth-regulated human ubiquitin isopeptidase
EMBO J.
17
3241-3250
1998
Homo sapiens (P40818), Homo sapiens
Gong, L.; Kamitani, T.; Millas, S.; Yeh, E.T.
Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins
J. Biol. Chem.
275
14212-14216
2000
Homo sapiens (Q9UK80), Homo sapiens
Mullally, J.E.; Moos, P.J.; Edes, K.; Fitzpatrick, F.A.
Cyclopentenone prostaglandins of the J series inhibit the ubiquitin isopeptidase activity of the proteasome pathway
J. Biol. Chem.
276
30366-30373
2001
Homo sapiens
Gabriel, J.M.; Lacombe, T.; Carobbio, S.; Paquet, N.; Bisig, R.; Cox, J.A.; Jaton, J.C.
Zinc is required for the catalytic activity of the human deubiquitinating isopeptidase T
Biochemistry
41
13755-13766
2002
Homo sapiens
Nishikawa, K.; Li, H.; Kawamura, R.; Osaka, H.; Wang, Y.L.; Hara, Y.; Hirokawa, T.; Manago, Y.; Amano, T.; Noda, M.; Aoki, S.; Wada, K.
Alterations of structure and hydrolase activity of parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants
Biochem. Biophys. Res. Commun.
304
176-183
2003
Homo sapiens (P09936), Homo sapiens
Son, O.L.; Kim, H.T.; Ji, M.H.; Yoo, K.W.; Rhee, M.; Kim, C.H.
Cloning and expression analysis of a Parkinson's disease gene, uch-L1, and its promoter in zebrafish
Biochem. Biophys. Res. Commun.
312
601-607
2003
Danio rerio, Danio rerio (Q6YI49), Homo sapiens (P09936), Homo sapiens
Naito, S.; Mochizuki, H.; Yasuda, T.; Mizuno, Y.; Furusaka, M.; Ikeda, S.; Adachi, T.; Shimizu, H.M.; Suzuki, J.; Fujiwara, S.; Okada, T.; Nishikawa, K.; Aoki, S.; Wada, K.
Characterization of multimetric variants of ubiquitin carboxyl-terminal hydrolase L1 in water by small-angle neutron scattering
Biochem. Biophys. Res. Commun.
339
717-725
2006
Homo sapiens
Case, A.; Stein, R.L.
Mechanistic studies of ubiquitin C-terminal hydrolase L1
Biochemistry
45
2443-2452
2006
Homo sapiens, Homo sapiens (P09936)
Liu, Y.; Lashuel, H.A.; Choi, S.; Xing, X.; Case, A.; Ni, J.; Yeh, L.A.; Cuny, G.D.; Stein, R.L.; Lansbury, P.T., Jr.
Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line
Chem. Biol.
10
837-846
2003
Homo sapiens
Choi, J.; Levey, A.I.; Weintraub, S.T.; Rees, H.D.; Gearing, M.; Chin, L.S.; Li, L.
Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases
J. Biol. Chem.
279
13256-13264
2004
Homo sapiens, Homo sapiens (P09936)
McCullough, J.; Clague, M.J.; Urbe, S.
AMSH is an endosome-associated ubiquitin isopeptidase
J. Cell Biol.
166
487-492
2004
Homo sapiens
Sakurai, M.; Ayukawa, K.; Setsuie, R.; Nishikawa, K.; Hara, Y.; Ohashi, H.; Nishimoto, M.; Abe, T.; Kudo, Y.; Sekiguchi, M.; Sato, Y.; Aoki, S.; Noda, M.; Wada, K.
Ubiquitin C-terminal hydrolase L1 regulates the morphology of neural progenitor cells and modulates their differentiation
J. Cell Sci.
119
162-171
2006
Homo sapiens, Mus musculus, Mus musculus (Q9R0P9)
Manago, Y.; Kanahori, Y.; Shimada, A.; Sato, A.; Amano, T.; Sato-Sano, Y.; Setsuie, R.; Sakurai, M.; Aoki, S.; Wang, Y.L.; Osaka, H.; Wada, K.; Noda, M.
Potentiation of ATP-induced currents due to the activation of P2X receptors by ubiquitin carboxy-terminal hydrolase L1
J. Neurochem.
92
1061-1072
2005
Homo sapiens, Rattus norvegicus
Barrachina, M.; Castano, E.; Dalfo, E.; Maes, T.; Buesa, C.; Ferrer, I.
Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies
Neurobiol. Dis.
22
265-273
2006
Homo sapiens
Das, C.; Hoang, Q.Q.; Kreinbring, C.A.; Luchansky, S.J.; Meray, R.K.; Ray, S.S.; Lansbury, P.T.; Ringe, D.; Petsko, G.A.
Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1
Proc. Natl. Acad. Sci. USA
103
4675-4680
2006
Homo sapiens (P15374), Homo sapiens
Solano, S.M.; Miller, D.W.; Augood, S.J.; Young, A.B.; Penney, J.B.
Expression of alpha-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase L1 mRNA in human brain: genes associated with familial Parkinsons disease
Ann. Neurol.
47
201-210
2000
Homo sapiens (P09936), Homo sapiens
Shen, H.; Sikorska, M.; Leblanc, J.; Walker, P.R.; Liu, Q.Y.
Oxidative stress regulated expression of ubiquitin carboxyl-terminal hydrolase-L1: role in cell survival
Apoptosis
11
1049-1059
2006
Homo sapiens, Homo sapiens (P09936)
Misaghi, S.; Galardy, P.J.; Meester, W.J.; Ovaa, H.; Ploegh, H.L.; Gaudet, R.
Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate
J. Biol. Chem.
280
1512-1520
2005
Homo sapiens (P15374), Homo sapiens
Alexander-Kaufman, K.; James, G.; Sheedy, D.; Harper, C.; Matsumoto, I.
Differential protein expression in the prefrontal white matter of human alcoholics: a proteomics study
Mol. Psychiatry
11
56-65
2006
Homo sapiens (P09936), Homo sapiens
Facheris, M.; Strain, K.J.; Lesnick, T.G.; de Andrade, M.; Bower, J.H.; Ahlskog, J.E.; Cunningham, J.M.; Lincoln, S.; Farrer, M.J.; Rocca, W.A.; Maraganore, D.M.
UCHL1 is associated with Parkinsons disease: A case-unaffected sibling and case-unrelated control study
Neurosci. Lett.
381
131-134
2005
Homo sapiens (P09936)
Wicks, S.J.; Haros, K.; Maillard, M.; Song, L.; Cohen, R.E.; Dijke, P.T.; Chantry, A.
The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling
Oncogene
24
8080-8084
2005
Homo sapiens (Q9Y5K5), Homo sapiens
Hassiepen, U.; Eidhoff, U.; Meder, G.; Bulber, J.F.; Hein, A.; Bodendorf, U.; Lorthiois, E.; Martoglio, B.
A sensitive fluorescence intensity assay for deubiquitinating proteases using ubiquitin-rhodamine110-glycine as substrate
Anal. Biochem.
371
201-207
2007
Homo sapiens
Takami, Y.; Nakagami, H.; Morishita, R.; Katsuya, T.; Cui, T.X.; Ichikawa, T.; Saito, Y.; Hayashi, H.; Kikuchi, Y.; Nishikawa, T.; Baba, Y.; Yasuda, O.; Rakugi, H.; Ogihara, T.; Kaneda, Y.
Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kappaB activation
Arterioscler. Thromb. Vasc. Biol.
27
2184-2190
2007
Homo sapiens
Schweitzer, K.; Decker, E.; Zhu, L.; Miller, R.E.; Mirra, S.S.; Spina, S.; Ghetti, B.; Wang, M.; Murrell, J.
Aberrantly regulated proteins in frontotemporal dementia
Biochem. Biophys. Res. Commun.
348
465-472
2006
Homo sapiens (P09936), Homo sapiens
Wicks, S.J.; Grocott, T.; Haros, K.; Maillard, M.; ten Dijke, P.; Chantry, A.
Reversible ubiquitination regulates the Smad/TGF-beta signalling pathway
Biochem. Soc. Trans.
34
761-763
2006
Homo sapiens
Hirayama, K.; Aoki, S.; Nishikawa, K.; Matsumoto, T.; Wada, K.
Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening
Bioorg. Med. Chem.
15
6810-6818
2007
Homo sapiens
Carolan, B.J.; Heguy, A.; Harvey, B.G.; Leopold, P.L.; Ferris, B.; Crystal, R.G.
Up-regulation of expression of the ubiquitin carboxyl-terminal hydrolase L1 gene in human airway epithelium of cigarette smokers
Cancer Res.
66
10729-10740
2006
Homo sapiens
Miyoshi, Y.; Nakayama, S.; Torikoshi, Y.; Tanaka, S.; Ishihara, H.; Taguchi, T.; Tamaki, Y.; Noguchi, S.
High expression of ubiquitin carboxy-terminal hydrolase-L1 and -L3 mRNA predicts early recurrence in patients with invasive breast cancer
Cancer Sci.
97
523-529
2006
Homo sapiens
Lansbury, P.T.
Improving synaptic function in a mouse model of AD
Cell
126
655-657
2006
Aplysia sp., Homo sapiens, Mus musculus
Bifsha, P.; Landry, K.; Ashmarina, L.; Durand, S.; Seyrantepe, V.; Trudel, S.; Quiniou, C.; Chemtob, S.; Xu, Y.; Gravel, R.A.; Sladek, R.; Pshezhetsky, A.V.
Altered gene expression in cells from patients with lysosomal storage disorders suggests impairment of the ubiquitin pathway
Cell Death Differ.
14
511-523
2007
Mus musculus, Homo sapiens (P09936), Homo sapiens
Roth, G.; Freund, S.; Moehrle, B.; Woellner, K.; Bruenjes, J.; Gauglitz, G.; Wiesmueller, K.H.; Jung, G.
Ubiquitin binds to a short peptide segment of hydrolase UCH-L3: a study by FCS, RIfS, ITC and NMR
Chembiochem
8
323-331
2007
Homo sapiens
Gong, B.; Leznik, E.
The role of ubiquitin C-terminal hydrolase L1 in neurodegenerative disorders
Drug News Perspect.
20
365-370
2007
Homo sapiens
Kabuta, T.; Setsuie, R.; Mitsui, T.; Kinugawa, A.; Sakurai, M.; Aoki, S.; Uchida, K.; Wada, K.
Aberrant molecular properties shared by familial Parkinsons disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1
Hum. Mol. Genet.
17
1482-1496
2008
Homo sapiens
Meray, R.K.; Lansbury, P.T.
Reversible monoubiquitination regulates the Parkinson disease-associated ubiquitin hydrolase UCH-L1
J. Biol. Chem.
282
10567-10575
2007
Homo sapiens
Toda, T.; Nakamura, M.; Morisawa, H.; Hirota, M.
Proteomic identification of oxidative-stress-reporting biomarkers differentially secreted from human neuroblastoma SH-SY5Y cells
J. Electrophor.
51
21-26
2007
Homo sapiens (P09936)
-
Rolen, U.; Kobzeva, V.; Gasparjan, N.; Ovaa, H.; Winberg, G.; Kisseljov, F.; Masucci, M.G.
Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines
Mol. Carcinog.
45
260-269
2006
Homo sapiens
Yao, T.; Song, L.; Xu, W.; DeMartino, G.N.; Florens, L.; Swanson, S.K.; Washburn, M.P.; Conaway, R.C.; Conaway, J.W.; Cohen, R.E.
Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1
Nat. Cell Biol.
8
994-1002
2006
Bos taurus (Q9XSJ0), Homo sapiens (Q9Y5K5)
Raichur, A.; Vali, S.; Gorin, F.
Dynamic modeling of alpha-synuclein aggregation for the sporadic and genetic forms of Parkinsons disease
Neuroscience
142
859-870
2006
Homo sapiens
Carmine Belin, A.; Westerlund, M.; Bergman, O.; Nissbrandt, H.; Lind, C.; Sydow, O.; Galter, D.
S18Y in ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) associated with decreased risk of Parkinsons disease in Sweden
Parkinsonism Relat. Disord.
13
295-298
2007
Homo sapiens
Ha, M.K.; Soo Cho, J.; Baik, O.R.; Lee, K.H.; Koo, H.S.; Chung, K.Y.
Caenorhabditis elegans as a screening tool for the endothelial cell-derived putative aging-related proteins detected by proteomic analysis
Proteomics
6
3339-3351
2006
Caenorhabditis elegans, Homo sapiens (P09936), Caenorhabditis elegans N2
Drag, M.; Mikolajczyk, J.; Bekes, M.; Reyes-Turcu, F.E.; Ellman, J.A.; Wilkinson, K.D.; Salvesen, G.S.
Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes)
Biochem. J.
415
367-375
2008
Severe acute respiratory syndrome-related coronavirus, Homo sapiens (P15374), Homo sapiens (P45974), Homo sapiens (Q5VVQ6), Homo sapiens
Tanaka, T.; Kuramitsu, Y.; Fujimoto, M.; Naito, S.; Oka, M.; Nakamura, K.
Downregulation of two isoforms of ubiquitin carboxyl-terminal hydrolase isozyme L1 correlates with high metastatic potentials of human SN12C renal cell carcinoma cell clones
Electrophoresis
29
2651-2659
2008
Homo sapiens (P09936), Homo sapiens
Yu, J.; Tao, Q.; Cheung, K.F.; Jin, H.; Poon, F.F.; Wang, X.; Li, H.; Cheng, Y.Y.; Roecken, C.; Ebert, M.P.; Chan, A.T.; Sung, J.J.
Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors
Hepatology
48
508-518
2008
Homo sapiens (P09936)
Wang, W.J.; Li, Q.Q.; Xu, J.D.; Cao, X.X.; Li, H.X.; Tang, F.; Chen, Q.; Yang, J.M.; Xu, Z.D.; Liu, X.P.
Over-expression of ubiquitin carboxy terminal hydrolase-L1 induces apoptosis in breast cancer cells
Int. J. Oncol.
33
1037-1045
2008
Homo sapiens (P09936), Homo sapiens
Enesa, K.; Zakkar, M.; Chaudhury, H.; Luong, l.e..A.; Rawlinson, L.; Mason, J.C.; Haskard, D.O.; Dean, J.L.; Evans, P.C.
NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling
J. Biol. Chem.
283
7036-7045
2008
Homo sapiens
Rolen, U.; Freda, E.; Xie, J.; Pfirmann, T.; Frisan, T.; Masucci, M.G.
The Ubiquitin C-terminal Hydrolase UCH-L1 regulates B-cell proliferation and integrin activation
J. Cell. Mol. Med.
13
1666-1678
2009
Homo sapiens, Homo sapiens (P09936)
Meyer-Schwesinger, C.; Meyer, T.N.; Muenster, S.; Klug, P.; Saleem, M.; Helmchen, U.; Stahl, R.A.
A new role for the neuronal ubiquitin C-terminal hydrolase-L1 (UCH-L1) in podocyte process formation and podocyte injury in human glomerulopathies
J. Pathol.
217
452-464
2009
Homo sapiens (P09936), Homo sapiens
Misaghi, S.; Ottosen, S.; Izrael-Tomasevic, A.; Arnott, D.; Lamkanfi, M.; Lee, J.; Liu, J.; ORourke, K.; Dixit, V.M.; Wilson, A.C.
Association of C-terminal ubiquitin hydrolase BAP1 with cell cycle regulator HCF-1
Mol. Cell. Biol.
29
2181-2192
2009
Homo sapiens (Q92560)
Yao, T.; Song, L.; Jin, J.; Cai, Y.; Takahashi, H.; Swanson, S.K.; Washburn, M.P.; Florens, L.; Conaway, R.C.; Cohen, R.E.; Conaway, J.W.
Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex
Mol. Cell
31
909-917
2008
Homo sapiens (Q9Y5K5), Homo sapiens
Setsuie, R.; Sakurai, M.; Sakaguchi, Y.; Wada, K.
Ubiquitin dimers control the hydrolase activity of UCH-L3
Neurochem. Int.
54
314-321
2009
Homo sapiens (P09936), Homo sapiens (P15374), Mus musculus (Q9JKB1), Mus musculus (Q9R0P9)
Kim, H.J.; Kim, Y.M.; Lim, S.; Nam, Y.K.; Jeong, J.; Kim, H.J.; Lee, K.J.
Ubiquitin C-terminal hydrolase-L1 is a key regulator of tumor cell invasion and metastasis
Oncogene
28
117-127
2009
Homo sapiens (P09936)
Nishio, K.; Kim, S.W.; Kawai, K.; Mizushima, T.; Yamane, T.; Hamazaki, J.; Murata, S.; Tanaka, K.; Morimoto, Y.
Crystal structure of the de-ubiquitinating enzyme UCH37 (human UCH-L5) catalytic domain
Biochem. Biophys. Res. Commun.
390
855-860
2009
Homo sapiens (Q9Y5K5)
Fang, Y.; Fu, D.; Shen, X.Z.
The potential role of ubiquitin C-terminal hydrolases in oncogenesis
Biochim. Biophys. Acta
1806
1-6
2010
Homo sapiens, Mus musculus
Andersson, F.I.; Jackson, S.E.; Hsu, S.T.
Backbone assignments of the 26 kDa neuron-specific ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1)
Biomol. NMR Assign.
4
41-43
2009
Homo sapiens (P09936), Homo sapiens
Weber, B.; Schaper, C.; Wang, Y.; Scholz, J.; Bein, B.
Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation
Cell. Signal.
21
1513-1521
2009
Homo sapiens (P09936)
Li, L.; Tao, Q.; Jin, H.; van Hasselt, A.; Poon, F.F.; Wang, X.; Zeng, M.S.; Jia, W.H.; Zeng, Y.X.; Chan, A.T.; Cao, Y.
The tumor suppressor UCHL1 forms a complex with p53/MDM2/ARF to promote p53 signaling and is frequently silenced in nasopharyngeal carcinoma
Clin. Cancer Res.
16
2949-2958
2010
Homo sapiens
Wu, Y.R.; Chen, C.M.; Chen, Y.C.; Chao, C.Y.; Ro, L.S.; Fung, H.C.; Hsiao, Y.C.; Hu, F.J.; Lee-Chen, G.J.
Ubiquitin specific proteases USP24 and USP40 and ubiquitin thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Parkinsons disease among Taiwanese
Clin. Chim. Acta
411
955-958
2010
Homo sapiens
Papa, L.; Akinyi, L.; Liu, M.C.; Pineda, J.A.; Tepas, J.J.; Oli, M.W.; Zheng, W.; Robinson, G.; Robicsek, S.A.; Gabrielli, A.; Heaton, S.C.; Hannay, H.J.; Demery, J.A.; Brophy, G.M.; Layon, J.; Robertson, C.S.; Hayes, R.L.; Wang, K.K.
Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury
Crit. Care Med.
38
138-144
2010
Homo sapiens
Henderson, M.J.; Vij, N.; Zeitlin, P.L.
Ubiquitin C-terminal hydrolase-L1 protects cystic fibrosis transmembrane conductance regulator from early stages of proteasomal degradation
J. Biol. Chem.
285
11314-11325
2010
Homo sapiens
Kang, X.; Sun, L.; Guo, K.; Shu, H.; Yao, J.; Qin, X.; Liu, Y.
Serum protein biomarkers screening in HCC patients with liver cirrhosis by ICAT-LC-MS/MS
J. Cancer Res. Clin. Oncol.
136
1151-1159
2010
Homo sapiens
Ma, Y.; Zhao, M.; Zhong, J.; Shi, L.; Luo, Q.; Liu, J.; Wang, J.; Yuan, X.; Huang, C.
Proteomic profiling of proteins associated with lymph node metastasis in colorectal cancer
J. Cell. Biochem.
110
1512-1519
2010
Homo sapiens
Lewis, S.B.; Wolper, R.; Chi, Y.Y.; Miralia, L.; Wang, Y.; Yang, C.; Shaw, G.
Identification and preliminary characterization of ubiquitin C terminal hydrolase 1 (UCHL1) as a biomarker of neuronal loss in aneurysmal subarachnoid hemorrhage
J. Neurosci. Res.
88
1475-1484
2010
Homo sapiens
Seliger, B.; Handke, D.; Schabel, E.; Bukur, J.; Lichtenfels, R.; Dammann, R.
Epigenetic control of the ubiquitin carboxyl terminal hydrolase 1 in renal cell carcinoma
J. Transl. Med.
7
90
2009
Homo sapiens
Iizuka, N.; Okamoto, K.; Matsushita, R.; Kimura, M.; Nagai, K.; Arito, M.; Kurokawa, M.S.; Masuko, K.; Suematsu, N.; Hirohata, S.; Kato, T.
Identification of autoantigens specific for systemic lupus erythematosus with central nervous system involvement
Lupus
19
717-726
2010
Homo sapiens
Zetterberg, M.; Sjoelander, A.; von Otter, M.; Palmer, M.S.; Landgren, S.; Minthon, L.; Wallin, A.; Andreasen, N.; Blennow, K.; Zetterberg, H.
Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimers disease
Mol. Neurodegener.
5
11
2010
Homo sapiens (P09936), Homo sapiens
Mitsui, T.; Hirayama, K.; Aoki, S.; Nishikawa, K.; Uchida, K.; Matsumoto, T.; Kabuta, T.; Wada, K.
Identification of a novel chemical potentiator and inhibitors of UCH-L1 by in silico drug screening
Neurochem. Int.
56
679-686
2010
Homo sapiens (P09936), Homo sapiens
Bheda, A.; Yue, W.; Gullapalli, A.; Whitehurst, C.; Liu, R.; Pagano, J.S.; Shackelford, J.
Positive reciprocal regulation of ubiquitin C-terminal hydrolase L1 and beta-catenin/TCF signaling
PLoS ONE
4
e5955
2009
Homo sapiens, Mus musculus
Liu, Z.; Meray, R.K.; Grammatopoulos, T.N.; Fredenburg, R.A.; Cookson, M.R.; Liu, Y.; Logan, T.; Lansbury, P.T.
Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinsons disease
Proc. Natl. Acad. Sci. USA
106
4635-4640
2009
Homo sapiens, Mus musculus
Koharudin, L.M.; Liu, H.; Di Maio, R.; Kodali, R.B.; Graham, S.H.; Gronenborn, A.M.
Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1
Proc. Natl. Acad. Sci. USA
107
6835-6840
2010
Homo sapiens
Boudreaux, D.A.; Maiti, T.K.; Davies, C.W.; Das, C.
Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation
Proc. Natl. Acad. Sci. USA
107
9117-9122
2010
Homo sapiens (P09936)
Day, I.N.; Thompson, R.J.
UCHL1 (PGP 9.5): neuronal biomarker and ubiquitin system protein
Prog. Neurobiol.
90
327-362
2010
Bos taurus, Homo sapiens, Macaca fuscata, Mus musculus, Rattus norvegicus
Seliger, B.; Dressler, S.P.; Wang, E.; Kellner, R.; Recktenwald, C.V.; Lottspeich, F.; Marincola, F.M.; Baumgaertner, M.; Atkins, D.; Lichtenfels, R.
Combined analysis of transcriptome and proteome data as a tool for the identification of candidate biomarkers in renal cell carcinoma
Proteomics
9
1567-1581
2009
Homo sapiens (P09936)
Song, H.M.; Lee, J.E.; Kim, J.H.
Ubiquitin C-terminal hydrolase-L3 regulates EMT process and cancer metastasis in prostate cell lines
Biochem. Biophys. Res. Commun.
452
722-727
2014
Homo sapiens (P15374)
Navarro, M.F.; Carmody, L.; Romo-Fewell, O.; Lokensgard, M.E.; Love, J.J.
Characterizing substrate selectivity of ubiquitin C-terminal hydrolase-L3 using engineered alpha-linked ubiquitin substrates
Biochemistry
53
8031-8042
2014
Homo sapiens (P15374), Homo sapiens
Davies, C.W.; Chaney, J.; Korbel, G.; Ringe, D.; Petsko, G.A.; Ploegh, H.; Das, C.
The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK)
Bioorg. Med. Chem. Lett.
22
3900-3904
2012
Homo sapiens (P09936)
Zheng, S.; Qiao, G.; Min, D.; Zhang, Z.; Lin, F.; Yang, Q.; Feng, T.; Tang, L.; Sun, Y.; Zhao, H.; Li, H.; Yu, W.; Yang, Y.; Shen, Z.; Yao, Y.
Heterogeneous expression and biological function of ubiquitin carboxy-terminal hydrolase-L1 in osteosarcoma
Cancer Lett.
359
36-46
2015
Homo sapiens (P09936)
Pang, L.; Wu, Y.; Dong, N.; Xu, D.H.; Wang, D.W.; Wang, Z.H.; Li, X.L.; Bian, M.; Zhao, H.J.; Liu, X.L.; Zhang, N.
Elevated serum ubiquitin C-terminal hydrolase-L1 levels in patients with carbon monoxide poisoning
Clin. Biochem.
47
72-76
2014
Homo sapiens
Chipumuro, E.; Henriksen, M.
The ubiquitin hydrolase USP22 contributes to 3'-end processing of JAK-STAT-inducible genes
FASEB J.
26
842-854
2012
Homo sapiens
Boudreaux, D.A.; Chaney, J.; Maiti, T.K.; Das, C.
Contribution of active site glutamine to rate enhancement in ubiquitin C-terminal hydrolases
FEBS J.
279
1106-1118
2012
Homo sapiens (P09936), Homo sapiens (P15374), Homo sapiens (Q9Y5K5)
Wulfaenger, J.; Biehl, K.; Tetzner, A.; Wild, P.; Ikenberg, K.; Meyer, S.; Seliger, B.
Heterogeneous expression and functional relevance of the ubiquitin carboxyl-terminal hydrolase L1 in melanoma
Int. J. Cancer
133
2522-2532
2013
Homo sapiens (P09936), Homo sapiens
Kabuta, T.; Mitsui, T.; Takahashi, M.; Fujiwara, Y.; Kabuta, C.; Konya, C.; Tsuchiya, Y.; Hatanaka, Y.; Uchida, K.; Hohjoh, H.; Wada, K.
Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity
J. Biol. Chem.
288
12615-12626
2013
Homo sapiens (P09936), Homo sapiens
Bishop, P.; Rubin, P.; Thomson, A.R.; Rocca, D.; Henley, J.M.
The ubiquitin C-terminal hydrolase L1 (UCH-L1) C terminus plays a key role in protein stability, but its farnesylation is not required for membrane association in primary neurons
J. Biol. Chem.
289
36140-36149
2014
Homo sapiens (P09936)
Diaz-Arrastia, R.; Wang, K.K.; Papa, L.; Sorani, M.D.; Yue, J.K.; Puccio, A.M.; McMahon, P.J.; Inoue, T.; Yuh, E.L.; Lingsma, H.F.; Maas, A.I.; Valadka, A.B.; Okonkwo, D.O.; Manley, G.T.; Manley, G.T.
Acute biomarkers of traumatic brain injury: relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein
J. Neurotrauma
31
19-25
2014
Homo sapiens
Song, I.K.; Kim, H.J.; Magesh, V.; Lee, K.J.
Ubiquitin C-terminal hydrolase-L1 plays a key role in angiogenesis by regulating hydrogen peroxide generated by NADPH oxidase 4
Biochem. Biophys. Res. Commun.
495
1567-1572
2018
Homo sapiens (P09936), Homo sapiens
Bishop, P.; Rocca, D.; Henley, J.M.
Ubiquitin C-terminal hydrolase L1 (UCH-L1) structure, distribution and roles in brain function and dysfunction
Biochem. J.
473
2453-2462
2016
Homo sapiens (P09936), Mus musculus (Q9R0P9)
Kang, S.J.; Kim, J.S.; Park, S.M.
Ubiquitin C-terminal hydrolase L1 regulates lipid raft-dependent endocytosis
Exp. Neurobiol.
27
377-386
2018
Homo sapiens (P09936)
Wang, W.; Zou, L.; Zhou, D.; Zhou, Z.; Tang, F.; Xu, Z.; Liu, X.
Overexpression of ubiquitin carboxyl terminal hydrolase-L1 enhances multidrug resistance and invasion/metastasis in breast cancer by activating the MAPK/Erk signaling pathway
Mol. Carcinog.
55
1329-1342
2016
Homo sapiens (P09936)
Toliczenko-Bernatowicz, D.; Matuszczak, E.; Tylicka, M.; Szymanska, B.; Komarowska, M.; Gorodkiewicz, E.; Debek, W.; Hermanowicz, A.
Overexpression of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) in boys with cryptorchidism
PLoS ONE
13
e0191806
2018
Homo sapiens (P09936), Homo sapiens
Nan, L.; Jacko, A.M.; Tan, J.; Wang, D.; Zhao, J.; Kass, D.J.; Ma, H.; Zhao, Y.
Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGFbeta-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosis
Sci. Rep.
6
33116
2016
Homo sapiens (Q9Y5K5), Homo sapiens
