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angiotensin + H2O
Asp + des-Asp-angiotensin
angiotensin I + H2O
Asp + Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu
angiotensin I + H2O
Asp + des-Asp-angiotensin I
-
-
-
-
?
angiotensin I + H2O
L-Asp + des-Asp-angiotensin I
-
-
-
?
angiotensin II + H2O
Asp + angiotensin III
angiotensin II antipeptide + H2O
?
-
-
-
-
?
angiotensin II antipeptide + H2O
Glu + Gly-Val-Thr-Val-His-Pro-Val
-
i.e. Glu-Gly-Val-Thr-Val-His-Pro-Val
-
-
?
angiotensinogen 1-14 + H2O
?
-
-
-
-
?
angiotensinogen 1-14 + H2O
Asp + Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser
-
i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser, low activity
-
-
?
Arg 2-naphthylamide + H2O
Arg + 2-naphthylamine
-
-
-
?
Asp 2-naphthylamide + H2O
Asp + 2-naphthylamine
Asp-2-naphthylamide + H2O
Asp + 2-naphthylamine
Asp-7-amido-4-methylcoumarin + H2O
Asp + 7-amino-4-methylcoumarin
-
-
-
-
?
Asp-Ala + H2O
Asp + Ala
-
-
-
?
Asp-Ala-Pro-2-naphthylamide + H2O
Asp + Ala-Pro-2-naphthylamide
-
preferring acidic amino acids favouring aspartyl residues, requires a free alpha-amino group
-
?
Asp-Ala-Pro-chromogen + H2O
Asp + Ala-Pro-chromogen
Asp-Ala-Pro-sulfamethoxazole + H2O
Asp + Ala-Pro-sulfamethoxazole
Asp-Lys + H2O
Asp + Lys
-
-
-
?
Asp-Lys-Ala-Leu + H2O
Asp + Lys-Ala-Leu
Asp-p-nitroanilide + H2O
Asp + p-nitroaniline
64% activity
-
-
?
Asp-Xaa + H2O
Asp + Xaa
-
-
-
r
Asp-Xaa-Xaa + H2O
Asp + Xaa-Xaa
-
no activity on oligopeptides larger than tripeptides
-
r
Asp-Xaa-Xaa-Xaa + H2O
Asp + Xaa-Xaa-Xaa
-
neutral or hydrophobic amino acids in P1 position preferred
-
?
aspartyl peptides + H2O
Asp + des-Asp-angiotensin
Glu 2-naphthylamide + H2O
Glu + 2-naphthylamine
Glu-7-amido-4-methylcoumarin + H2O
Glu + 7-amino-4-methylcoumarin
-
-
-
-
?
Glu-Ala-Pro-naphthylamide + H2O
Glu + Ala-Pro-naphthylamide
-
-
-
-
?
Glu-p-nitroanilide + H2O
Glu + p-nitroaniline
100% activity
-
-
?
L-Asp-2-naphthylamide + H2O
L-Asp + 2-naphthylamine
-
-
-
-
?
L-Asp-4-nitroanilide + H2O
L-Asp + 4-nitroaniline
L-Asp-7-amido-4-methylcoumarin + H2O
L-Asp + 7-amino-4-methylcoumarin
L-aspartyl-beta-naphthylamide + H2O
L-aspartic acid + beta-naphthylamine
-
-
-
?
L-Glu-4-nitroanilide + H2O
L-Glu + 4-nitroaniline
L-Glu-7-amido-4-methylcoumarin + H2O
L-Glu + 7-amino-4-methylcoumarin
Lys 2-naphthylamide + H2O
Lys + 2-naphthylamine
-
-
-
?
N-(alpha-L-aspartyl)-4-nitroanilide + H2O
L-aspartic acid + 4-nitroaniline
N-(alpha-L-glutamyl)-2-naphthylamide + H2O
L-glutamic acid + 2-naphthylamine
N-(alpha-L-glutamyl)-4-nitroanilide + H2O
L-glutamic acid + 4-nitroaniline
additional information
?
-
angiotensin + H2O

Asp + des-Asp-angiotensin
-
intracellular protein and peptide metabolism
-
?
angiotensin + H2O
Asp + des-Asp-angiotensin
-
metabolism of angiotensin I, angiotensin II, cholecystokinin-8 and neuropeptide, solube and membrane-bound AspAP play different functional roles in the brain
-
?
angiotensin + H2O
Asp + des-Asp-angiotensin
-
intracellular protein and peptide metabolism
-
?
angiotensin + H2O
Asp + des-Asp-angiotensin
-
-
-
?
angiotensin + H2O
Asp + des-Asp-angiotensin
-
intracellular protein and peptide metabolism
-
?
angiotensin I + H2O

?
-
-
-
-
?
angiotensin I + H2O
?
-
-
-
-
?
angiotensin I + H2O

Asp + Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu
-
i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu
-
-
?
angiotensin I + H2O
Asp + Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu
-
i.e. Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu
-
-
?
angiotensin II + H2O

?
-
-
-
-
?
angiotensin II + H2O
?
-
-
-
-
?
angiotensin II + H2O

Asp + angiotensin III
-
-
-
?
angiotensin II + H2O
Asp + angiotensin III
-
i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
-
?
angiotensin II + H2O
Asp + angiotensin III
-
i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
-
?
angiotensin II + H2O
Asp + angiotensin III
-
octapeptides preferred to tetrapeptides
-
?
angiotensin II + H2O
Asp + angiotensin III
-
i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
-
?
angiotensin II + H2O
Asp + angiotensin III
-
aspartyl aminopeptidase and several other aminopeptidases, i.e. angiotensinases, are involved in angiotensin II and cholecystokinin, CCK, metabolism, angiotensin II is the principal effector of the renin-angiotensin-system, RAS, which induces vasoconstriction and increases sodium and water retention thereby leading to increased blood pressure
-
-
?
angiotensin II + H2O
Asp + angiotensin III
-
i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
-
?
angiotensin II + H2O
Asp + angiotensin III
-
i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe, best substrate
i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
-
?
angiotensin II + H2O
Asp + angiotensin III
-
i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe, best substrate
i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
-
?
Asp 2-naphthylamide + H2O

Asp + 2-naphthylamine
-
higher affinity for Asp 2-naphthylamide than for Glu 2-naphthylamide
-
?
Asp 2-naphthylamide + H2O
Asp + 2-naphthylamine
-
-
-
?
Asp 2-naphthylamide + H2O
Asp + 2-naphthylamine
-
attacked more rapidly than 2-naphthylamide derivates of neutral or basic amino acids
-
?
Asp-2-naphthylamide + H2O

Asp + 2-naphthylamine
-
-
-
-
?
Asp-2-naphthylamide + H2O
Asp + 2-naphthylamine
-
-
-
-
?
Asp-2-naphthylamide + H2O
Asp + 2-naphthylamine
-
most susceptible substrate
-
-
?
Asp-Ala-Pro-chromogen + H2O

Asp + Ala-Pro-chromogen
-
-
-
-
?
Asp-Ala-Pro-chromogen + H2O
Asp + Ala-Pro-chromogen
-
-
-
-
?
Asp-Ala-Pro-chromogen + H2O
Asp + Ala-Pro-chromogen
-
-
-
-
?
Asp-Ala-Pro-sulfamethoxazole + H2O

Asp + Ala-Pro-sulfamethoxazole
-
-
-
-
?
Asp-Ala-Pro-sulfamethoxazole + H2O
Asp + Ala-Pro-sulfamethoxazole
-
-
-
?
Asp-Lys-Ala-Leu + H2O

Asp + Lys-Ala-Leu
-
lower activity
-
-
?
Asp-Lys-Ala-Leu + H2O
Asp + Lys-Ala-Leu
-
lower activity
-
-
?
Asp-Lys-Ala-Leu + H2O
Asp + Lys-Ala-Leu
-
lower activity
-
-
?
aspartyl peptides + H2O

Asp + des-Asp-angiotensin
-
catabolism of intracellular proteins, breakdown of abnormal cell proteins, supplement of nutritional sources
-
?
aspartyl peptides + H2O
Asp + des-Asp-angiotensin
-
activation and degradation of several neuropeptides, excitatory Asp and Glu implicated in pathogenesis of different neurogeneratives diseases
-
?
Glu 2-naphthylamide + H2O

Glu + 2-naphthylamine
-
-
-
?
Glu 2-naphthylamide + H2O
Glu + 2-naphthylamine
-
attacked more rapidly than 2-naphthylamide derivatives of neutral or basic amino acids
-
-
?
L-Asp-4-nitroanilide + H2O

L-Asp + 4-nitroaniline
-
-
-
?
L-Asp-4-nitroanilide + H2O
L-Asp + 4-nitroaniline
-
-
-
?
L-Asp-4-nitroanilide + H2O
L-Asp + 4-nitroaniline
-
-
-
?
L-Asp-4-nitroanilide + H2O
L-Asp + 4-nitroaniline
-
-
-
?
L-Asp-4-nitroanilide + H2O
L-Asp + 4-nitroaniline
-
-
-
?
L-Asp-4-nitroanilide + H2O
L-Asp + 4-nitroaniline
-
-
-
?
L-Asp-4-nitroanilide + H2O
L-Asp + 4-nitroaniline
-
-
-
-
?
L-Asp-4-nitroanilide + H2O
L-Asp + 4-nitroaniline
-
-
-
-
?
L-Asp-7-amido-4-methylcoumarin + H2O

L-Asp + 7-amino-4-methylcoumarin
-
-
-
?
L-Asp-7-amido-4-methylcoumarin + H2O
L-Asp + 7-amino-4-methylcoumarin
-
-
-
?
L-Asp-7-amido-4-methylcoumarin + H2O
L-Asp + 7-amino-4-methylcoumarin
-
-
-
?
L-Asp-7-amido-4-methylcoumarin + H2O
L-Asp + 7-amino-4-methylcoumarin
-
-
-
?
L-Glu-4-nitroanilide + H2O

L-Glu + 4-nitroaniline
-
-
-
?
L-Glu-4-nitroanilide + H2O
L-Glu + 4-nitroaniline
-
-
-
?
L-Glu-4-nitroanilide + H2O
L-Glu + 4-nitroaniline
-
-
-
?
L-Glu-4-nitroanilide + H2O
L-Glu + 4-nitroaniline
-
-
-
?
L-Glu-4-nitroanilide + H2O
L-Glu + 4-nitroaniline
-
-
-
?
L-Glu-4-nitroanilide + H2O
L-Glu + 4-nitroaniline
-
-
-
?
L-Glu-4-nitroanilide + H2O
L-Glu + 4-nitroaniline
-
-
-
-
?
L-Glu-4-nitroanilide + H2O
L-Glu + 4-nitroaniline
-
-
-
-
?
L-Glu-7-amido-4-methylcoumarin + H2O

L-Glu + 7-amino-4-methylcoumarin
-
-
-
?
L-Glu-7-amido-4-methylcoumarin + H2O
L-Glu + 7-amino-4-methylcoumarin
-
-
-
?
L-Glu-7-amido-4-methylcoumarin + H2O
L-Glu + 7-amino-4-methylcoumarin
-
-
-
?
L-Glu-7-amido-4-methylcoumarin + H2O
L-Glu + 7-amino-4-methylcoumarin
-
-
-
?
N-(alpha-L-aspartyl)-4-nitroanilide + H2O

L-aspartic acid + 4-nitroaniline
-
-
-
-
?
N-(alpha-L-aspartyl)-4-nitroanilide + H2O
L-aspartic acid + 4-nitroaniline
-
-
-
-
?
N-(alpha-L-aspartyl)-4-nitroanilide + H2O
L-aspartic acid + 4-nitroaniline
-
-
-
-
?
N-(alpha-L-glutamyl)-2-naphthylamide + H2O

L-glutamic acid + 2-naphthylamine
-
-
-
-
?
N-(alpha-L-glutamyl)-2-naphthylamide + H2O
L-glutamic acid + 2-naphthylamine
-
-
-
-
?
N-(alpha-L-glutamyl)-2-naphthylamide + H2O
L-glutamic acid + 2-naphthylamine
-
-
-
-
?
N-(alpha-L-glutamyl)-4-nitroanilide + H2O

L-glutamic acid + 4-nitroaniline
-
-
-
-
?
N-(alpha-L-glutamyl)-4-nitroanilide + H2O
L-glutamic acid + 4-nitroaniline
-
-
-
-
?
N-(alpha-L-glutamyl)-4-nitroanilide + H2O
L-glutamic acid + 4-nitroaniline
-
-
-
-
?
additional information

?
-
does not hydrolyze [Asn1, Val5]-angiotensin II, less than 0.5% activity on Ala-p-nitroanilide, Pro-p-nitroanilide, Met-p-nitroanilide, Arg-p-nitroanilide, and Leu-p-nitroanilide
-
-
?
additional information
?
-
does not hydrolyze [Asn1, Val5]-angiotensin II, less than 0.5% activity on Ala-p-nitroanilide, Pro-p-nitroanilide, Met-p-nitroanilide, Arg-p-nitroanilide, and Leu-p-nitroanilide
-
-
?
additional information
?
-
-
does not hydrolyze [Asn1, Val5]-angiotensin II, less than 0.5% activity on Ala-p-nitroanilide, Pro-p-nitroanilide, Met-p-nitroanilide, Arg-p-nitroanilide, and Leu-p-nitroanilide
-
-
?
additional information
?
-
enzyme AAP only hydrolyses Asp-4-nitroanilide and Glu-4-nitroanilide. The activity of AAP against Glu-4-nitroanilide corresponds to 43% of that against Asp-4-nitroanilide, indicating that this AAP is an aspartyl(glutamyl)-specific aminopeptidase
-
-
?
additional information
?
-
enzyme AAP only hydrolyses Asp-4-nitroanilide and Glu-4-nitroanilide. The activity of AAP against Glu-4-nitroanilide corresponds to 43% of that against Asp-4-nitroanilide, indicating that this AAP is an aspartyl(glutamyl)-specific aminopeptidase
-
-
?
additional information
?
-
-
enzyme AAP only hydrolyses Asp-4-nitroanilide and Glu-4-nitroanilide. The activity of AAP against Glu-4-nitroanilide corresponds to 43% of that against Asp-4-nitroanilide, indicating that this AAP is an aspartyl(glutamyl)-specific aminopeptidase
-
-
?
additional information
?
-
enzyme AAP only hydrolyses Asp-4-nitroanilide and Glu-4-nitroanilide. The activity of AAP against Glu-4-nitroanilide corresponds to 43% of that against Asp-4-nitroanilide, indicating that this AAP is an aspartyl(glutamyl)-specific aminopeptidase
-
-
?
additional information
?
-
enzyme AAP only hydrolyses Asp-4-nitroanilide and Glu-4-nitroanilide. The activity of AAP against Glu-4-nitroanilide corresponds to 43% of that against Asp-4-nitroanilide, indicating that this AAP is an aspartyl(glutamyl)-specific aminopeptidase
-
-
?
additional information
?
-
-
substrate specificity, overview, the substrate chain length is important for activity, the enzyme has little or no activity towards aminoacyl-arylamines, no or little activity towards aspartyl dipeptides with a positively charged residue in the second position
-
-
?
additional information
?
-
-
substrate specificity, overview, the substrate chain length is important for activity, the enzyme has little or no activity towards aminoacyl-arylamines, no or little activity towards aspartyl dipeptides with a positively charged residue in the second position
-
-
?
additional information
?
-
-
the enzyme catalyzes the hydrolysis of N-terminal alpha-L-glutamyl and alpha-L-aspartyl residues
-
-
?
additional information
?
-
-
substrate specificity, overview, the substrate chain length is important for activity, the enzyme has little or no activity towards aminoacyl-arylamines, no or little activity towards aspartyl dipeptides with a positively charged residue in the second position
-
-
?
additional information
?
-
-
no hydrolysis is observed against Leu-7-amido-4-methylcoumarin, Phe-7-amido-4-methylcoumarin, Ala-7-amido-4-methylcoumarin, Pro-7-amido-4-methylcoumarin, Gly-7-amido-4-methylcoumarin, Val-7-amido-4-methylcoumarin, Arg-7-amido-4-methylcoumarin, and Ile-7-amido-4-methylcoumarin
-
-
?
additional information
?
-
M18AAP is an exopeptidase that digests the N-terminal aspartic and glutamic acid which cannot be degraded by any other aminopeptidase
-
-
?
additional information
?
-
-
M18AAP is an exopeptidase that digests the N-terminal aspartic and glutamic acid which cannot be degraded by any other aminopeptidase
-
-
?
additional information
?
-
-
the enzyme is specific for unblocked N-terminal acidic amino acid residues, no activity with N-acetyl-angiotensinogen 1-14, Tyr-bradykinin, Ile-Ser-bradykinin, and [Sar1, Ala8]-angiotensin II, overview
-
-
?
additional information
?
-
-
the enzyme is specific for unblocked N-terminal acidic amino acid residues, no activity with N-acetyl-angiotensinogen 1-14, Tyr-bradykinin, Ile-Ser-bradykinin, and [Sar1, Ala8]-angiotensin II, overview
-
-
?
additional information
?
-
rTgAAP has a strict preference for Asp-7-amido-4-methylcoumarin and Glu-7-amido-4-methylcoumarin, the catalytic efficiency of the enzyme is higher with L-Glu-7-amido-4-methylcoumarin than with L-Asp-7-amido-4-methylcoumarin. No activity with Ala-, Arg-, Cys-, Leu-, Lys, Met-, Phe, Trp-, and Tyr-7-amido-4-methylcoumarin, and poor activity with His-, Ser-, and Pro-7-amido-4-methylcoumarin
-
-
?
additional information
?
-
-
rTgAAP has a strict preference for Asp-7-amido-4-methylcoumarin and Glu-7-amido-4-methylcoumarin, the catalytic efficiency of the enzyme is higher with L-Glu-7-amido-4-methylcoumarin than with L-Asp-7-amido-4-methylcoumarin. No activity with Ala-, Arg-, Cys-, Leu-, Lys, Met-, Phe, Trp-, and Tyr-7-amido-4-methylcoumarin, and poor activity with His-, Ser-, and Pro-7-amido-4-methylcoumarin
-
-
?
additional information
?
-
rTgAAP has a strict preference for Asp-7-amido-4-methylcoumarin and Glu-7-amido-4-methylcoumarin, the catalytic efficiency of the enzyme is higher with L-Glu-7-amido-4-methylcoumarin than with L-Asp-7-amido-4-methylcoumarin. No activity with Ala-, Arg-, Cys-, Leu-, Lys, Met-, Phe, Trp-, and Tyr-7-amido-4-methylcoumarin, and poor activity with His-, Ser-, and Pro-7-amido-4-methylcoumarin
-
-
?
additional information
?
-
rTgAAP has a strict preference for Asp-7-amido-4-methylcoumarin and Glu-7-amido-4-methylcoumarin, the catalytic efficiency of the enzyme is higher with L-Glu-7-amido-4-methylcoumarin than with L-Asp-7-amido-4-methylcoumarin. No activity with Ala-, Arg-, Cys-, Leu-, Lys, Met-, Phe, Trp-, and Tyr-7-amido-4-methylcoumarin, and poor activity with His-, Ser-, and Pro-7-amido-4-methylcoumarin
-
-
?
additional information
?
-
rTgAAP has a strict preference for Asp-7-amido-4-methylcoumarin and Glu-7-amido-4-methylcoumarin, the catalytic efficiency of the enzyme is higher with L-Glu-7-amido-4-methylcoumarin than with L-Asp-7-amido-4-methylcoumarin. No activity with Ala-, Arg-, Cys-, Leu-, Lys, Met-, Phe, Trp-, and Tyr-7-amido-4-methylcoumarin, and poor activity with His-, Ser-, and Pro-7-amido-4-methylcoumarin
-
-
?
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