Reference on EC 3.4.11.21 - aspartyl aminopeptidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Danielsen, E.M.; Noren, O.; Sjoestroem, H.; Ingram, J.; Kenny, A.J.
Proteins of the kidney microvillar membrane. Aspartate aminopeptidase: purification by immunoadsorbent chromatography and properties of the detergent- and proteinase-solubilized forms
Biochem. J.
189
591-603
1980
Sus scrofa
Ramirez-Exposito, M.J.; Martinez, J.M.; Prieto, I.; Alba, F.; Ramirez, M.
Comparative distribution of glutamyl and aspartyl aminopeptidase activities in mouse organs
Horm. Metab. Res.
32
161-163
2000
Mus musculus
Wilk, S.; Wilk, E.; Magnusson, R.P.
Purification, characterization and cloning of a cytosolic aspartyl aminopeptidase
J. Biol. Chem.
273
15961-15970
1998
Oryctolagus cuniculus, Homo sapiens, Rattus sp.
Iribar, C.; Esteban, M.J.; Martinez, J.M.; Peinado, J.M.
Decrease in cytosolic aspartyl-aminopeptidase but not in alanyl-aminopeptidase activity in the frontal cortex of the aged rat
Brain Res.
687
211-213
1995
Rattus sp.
Nathan, P.B.; Ahmad, S.I.; Griffin, M.
Identification and characterization of an aspartate-specific peptidase (peptidase E) in Escherichia coli K12
Biochem. Soc. Trans.
17
354
1989
Escherichia coli
-
Zhang, H.; Zhang, J.; Wang, X.; Yang, W.; Lu, J.
Biochemical characterization of alpha-aspartyl dipeptidase. Cloning and expression of its gene
Ann. N. Y. Acad. Sci.
864
621-625
1998
Salmonella enterica subsp. enterica serovar Typhimurium
Wilk, S.; Wilk, E.; Magnusson, R.P.
Identification of histidine residues important in the catalysis and structure of aspartyl aminopeptidase
Arch. Biochem. Biophys.
407
176-183
2002
Homo sapiens
Banegas, I.; Prieto, I.; Alba, F.; Vives, F.; Araque, A.; Segarra, A.B.; Duran, R.; de Gasparo, M.; Ramirez, M.
Angiotensinase activity is asymmetrically distributed in the amygdala, hippocampus and prefrontal cortex of the rat
Behav. Brain Res.
156
321-326
2005
Rattus norvegicus
Yokoyama, R.; Kawasaki, H.; Hirano, H.
Identification of yeast aspartyl aminopeptidase gene by purifying and characterizing its product from yeast cells
FEBS J.
273
192-198
2006
Saccharomyces cerevisiae, Saccharomyces cerevisiae B-8032
Adang, M.J.
Aminopeptidase A
Handbook of Proteolytic Enzymes (2nd Edition)
1
299-303
2004
Mus musculus
-
Simmons, W.H.
Aspartyl aminopeptidase
Handbook of Proteolytic Enzymes (2nd Edition)
1
937-939
2004
Oryctolagus cuniculus, Homo sapiens, Mus musculus
-
Gasparello-Clemente, E.; Casis, L.; Varona, A.; Gil, J.; Irazusta, J.; Silveira, P.F.
Aminopeptidases in visceral organs during alterations in body fluid volume and osmolality
Peptides
24
1367-1372
2003
Rattus norvegicus
Varona, A.; Blanco, L.; Lopez, J.I.; Gil, J.; Agirregoitia, E.; Irazusta, J.; Larrinaga, G.
Altered levels of acid, basic, and neutral peptidase activity and expression in human clear cell renal cell carcinoma
Am. J. Physiol. Renal Physiol.
292
F780-F788
2007
Homo sapiens
Watanabe, J.; Tanaka, H.; Akagawa, T.; Mogi, Y.; Yamazaki, T.
Characterization of Aspergillus oryzae aspartyl aminopeptidase expressed in Escherichia coli
Biosci. Biotechnol. Biochem.
71
2557-2560
2007
Aspergillus oryzae (Q2U9Z9), Aspergillus oryzae (Q2UPZ7), Aspergillus oryzae
Banegas, I.; Barrero, F.; Duran, R.; Morales, B.; Luna, J.D.; Prieto, I.; Ramirez, M.; Alba, F.; Vives, F.
Plasma aminopeptidase activities in Parkinsons disease
Horm. Metab. Res.
38
758-760
2006
Homo sapiens
Teuscher, F.; Lowther, J.; Skinner-Adams, T.S.; Spielmann, T.; Dixon, M.W.; Stack, C.M.; Donnelly, S.; Mucha, A.; Kafarski, P.; Vassiliou, S.; Gardiner, D.L.; Dalton, J.P.; Trenholme, K.R.
The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum
J. Biol. Chem.
282
30817-30826
2007
Plasmodium falciparum
Segarra, A.B.; Wangensteen, R.; Ramirez, M.; Banegas, I.; Hermoso, F.; Vargas, F.; Vives, F.; Duran, R.; Alba, F.; de Gasparo, M.; Prieto, I.
Atrial angiotensinase activity in hypothyroid, euthyroid, and hyperthyroid rats
J. Cardiovasc. Pharmacol.
48
117-120
2006
Rattus norvegicus
Banegas, I.; Prieto, I.; Vives, F.; Alba, F.; de Gasparo, M.; Segarra, A.B.; Hermoso, F.; Duran, R.; Ramirez, M.
Brain aminopeptidases and hypertension
J. Renin Angiotensin Aldosterone Syst.
7
129-134
2006
Rattus norvegicus
Lee, S.; Kim, J.S.; Yun, C.H.; Chae, H.Z.; Kim, K.
Aspartyl aminopeptidase of Schizosaccharomyces pombe has a molecular chaperone function
BMB Rep.
42
812-816
2009
Schizosaccharomyces pombe (O36014), Schizosaccharomyces pombe
Trenholme, K.R.; Brown, C.L.; Skinner-Adams, T.S.; Stack, C.; Lowther, J.; To, J.; Robinson, M.W.; Donnelly, S.M.; Dalton, J.P.; Gardiner, D.L.
Aminopeptidases of malaria parasites: new targets for chemotherapy
Infect. Disord. Drug Targets
10
217-225
2010
Plasmodium falciparum
Cai, W.W.; Wang, L.; Chen, Y.
Aspartyl aminopeptidase, encoded by an evolutionarily conserved syntenic gene, is colocalized with its cluster in secretory granules of pancreatic islet cells
Biosci. Biotechnol. Biochem.
74
2050-2055
2010
Mus musculus (Q9Z2W0)
Yuga, M.; Gomi, K.; Klionsky, D.J.; Shintani, T.
Aspartyl aminopeptidase is imported from the cytoplasm to the vacuole by selective autophagy in Saccharomyces cerevisiae
J. Biol. Chem.
286
13704-13713
2011
Saccharomyces cerevisiae
Lee, A.; Slattery, C.; Nikolic-Paterson, D.J.; Hryciw, D.H.; Wilk, S.; Wilk, E.; Zhang, Y.; Valova, V.A.; Robinson, P.J.; Kelly, D.J.; Poronnik, P.
Chloride channel ClC-5 binds to aspartyl aminopeptidase to regulate renal albumin endocytosis
Am. J. Physiol. Renal Physiol.
308
F784-F792
2015
Rattus norvegicus, Didelphis sp.
Chaikuad, A.; Pilka, E.; De Riso, A.; Von Delft, F.; Kavanagh, K.; Venien-Bryan, C.; Oppermann, U.; Yue, W.
Structure of human aspartyl aminopeptidase complexed with substrate analogue: Insight into catalytic mechanism, substrate specificity and M18 peptidase family
BMC Struct. Biol.
12
14
2012
Homo sapiens (Q9ULA0), Homo sapiens
Spicer, T.; Fernandez-Vega, V.; Chase, P.; Scampavia, L.; To, J.; Dalton, J.P.; Da Silva, F.L.; Skinner-Adams, T.S.; Gardiner, D.L.; Trenholme, K.R.; Brown, C.L.; Ghosh, P.; Porubsky, P.; Wang, J.L.; Whipple, D.A.; Schoenen, F.J.; Hodder, P.
Identification of potent and selective inhibitors of the Plasmodium falciparum M18 aspartyl aminopeptidase (PfM18AAP) of human malaria via high-throughput screening
J. Biomol. Screen.
19
1107-1115
2014
Plasmodium falciparum (Q8I2J3), Plasmodium falciparum
Rout, S.; Mahapatra, R.K.
In silico study of M18 aspartyl amino peptidase (M18AAP) of Plasmodium vivax as an antimalarial drug target
Bioorg. Med. Chem.
27
2553-2571
2019
Plasmodium vivax (A0A1G4HB34), Plasmodium vivax
Kumari, M.; Chandra, S.; Tiwari, N.; Subbarao, N.
3D QSAR, pharmacophore and molecular docking studies of known inhibitors and designing of novel inhibitors for M18 aspartyl aminopeptidase of Plasmodium falciparum
BMC Struct. Biol.
16
12
2016
Plasmodium falciparum (Q8I2J3), Plasmodium falciparum
Gao, X.; Yin, Y.; Zhou, C.
Purification, characterisation and salt-tolerance molecular mechanisms of aspartyl aminopeptidase from Aspergillus oryzae 3.042
Food Chem.
240
377-385
2018
Aspergillus oryzae (Q2UPZ7), Aspergillus oryzae 3.042 (Q2UPZ7), Aspergillus oryzae 3.042, Aspergillus oryzae RIB 40 (Q2UPZ7), Aspergillus oryzae ATCC 42149 (Q2UPZ7)
Stressler, T.; Ewert, J.; Merz, M.; Funk, J.; Claassen, W.; Lutz-Wahl, S.; Schmidt, H.; Kuhn, A.; Fischer, L.
A novel glutamyl (aspartyl)-specific aminopeptidase A from Lactobacillus delbrueckii with promising properties for application
PLoS ONE
11
e0152139
2016
Lactococcus lactis ssp. lactis, Lactobacillus delbrueckii subsp. lactis (F0HXE4), Lactobacillus delbrueckii subsp. lactis, Lactobacillus delbrueckii subsp. lactis DSM 20072 (F0HXE4), Lactococcus lactis ssp. lactis DSM 20481
Gontijo, F.A.; de Melo, A.T.; Pascon, R.C.; Fernandes, L.; Paes, H.C.; Alspaugh, J.A.; Vallim, M.A.
The role of aspartyl aminopeptidase (Ape4) in Cryptococcus neoformans virulence and authophagy
PLoS ONE
12
e0177461
2017
Cryptococcus neoformans var. grubii (J9VNI6), Cryptococcus neoformans var. grubii FGSC 9487 (J9VNI6), Cryptococcus neoformans var. grubii ATCC 208821 (J9VNI6), Cryptococcus neoformans var. grubii CBS 10515 (J9VNI6)
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