BRENDA - Enzyme Database show
show all sequences of 3.4.11.21

Comparative distribution of glutamyl and aspartyl aminopeptidase activities in mouse organs

Ramirez-Exposito, M.J.; Martinez, J.M.; Prieto, I.; Alba, F.; Ramirez, M.; Horm. Metab. Res. 32, 161-163 (2000)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
angiotensin + H2O
Mus musculus
metabolism of angiotensin I, angiotensin II, cholecystokinin-8 and neuropeptide, solube and membrane-bound AspAP play different functional roles in the brain
Asp + des-Asp-angiotensin
-
Mus musculus
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Mus musculus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
adrenal gland
-
Mus musculus
-
kidney
highest activity for membrane-bound Asp-AP
Mus musculus
-
liver
-
Mus musculus
-
lung
high levels for membrane-bound Asp-AP
Mus musculus
-
testis
highest activity for soluble Asp-AP
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
angiotensin + H2O
metabolism of angiotensin I, angiotensin II, cholecystokinin-8 and neuropeptide, solube and membrane-bound AspAP play different functional roles in the brain
137167
Mus musculus
Asp + des-Asp-angiotensin
-
137167
Mus musculus
?
Asp 2-naphthylamide + H2O
higher affinity for Asp 2-naphthylamide than for Glu 2-naphthylamide
137167
Mus musculus
Asp + 2-naphthylamine
-
137167
Mus musculus
?
Glu 2-naphthylamide + H2O
-
137167
Mus musculus
Glu + 2-naphthylamine
-
137167
Mus musculus
?
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
angiotensin + H2O
Mus musculus
metabolism of angiotensin I, angiotensin II, cholecystokinin-8 and neuropeptide, solube and membrane-bound AspAP play different functional roles in the brain
Asp + des-Asp-angiotensin
-
Mus musculus
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
adrenal gland
-
Mus musculus
-
kidney
highest activity for membrane-bound Asp-AP
Mus musculus
-
liver
-
Mus musculus
-
lung
high levels for membrane-bound Asp-AP
Mus musculus
-
testis
highest activity for soluble Asp-AP
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
angiotensin + H2O
metabolism of angiotensin I, angiotensin II, cholecystokinin-8 and neuropeptide, solube and membrane-bound AspAP play different functional roles in the brain
137167
Mus musculus
Asp + des-Asp-angiotensin
-
137167
Mus musculus
?
Asp 2-naphthylamide + H2O
higher affinity for Asp 2-naphthylamide than for Glu 2-naphthylamide
137167
Mus musculus
Asp + 2-naphthylamine
-
137167
Mus musculus
?
Glu 2-naphthylamide + H2O
-
137167
Mus musculus
Glu + 2-naphthylamine
-
137167
Mus musculus
?
Other publictions for EC 3.4.11.21
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
731109
Lee
Chloride channel ClC-5 binds t ...
Didelphis sp., Rattus norvegicus
Am. J. Physiol. Renal Physiol.
308
F784-F792
2015
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732193
Spicer
Identification of potent and s ...
Plasmodium falciparum
J. Biomol. Screen.
19
1107-1115
2014
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731558
Chaikuad
Structure of human aspartyl am ...
Homo sapiens
BMC Struct. Biol.
12
14
2012
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717822
Yuga
Aspartyl aminopeptidase is imp ...
Saccharomyces cerevisiae
J. Biol. Chem.
286
13704-13713
2011
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1
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1
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708702
Trenholme
Aminopeptidases of malaria par ...
Plasmodium falciparum
Infect. Disord. Drug Targets
10
217-225
2010
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717393
Cai
Aspartyl aminopeptidase, encod ...
Mus musculus
Biosci. Biotechnol. Biochem.
74
2050-2055
2010
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707859
Lee
Aspartyl aminopeptidase of Sch ...
Schizosaccharomyces pombe
BMB Rep.
42
812-816
2009
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1
1
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677492
Varona
Altered levels of acid, basic, ...
Homo sapiens
Am. J. Physiol. Renal Physiol.
292
F780-F788
2007
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678807
Watanabe
Characterization of Aspergillu ...
Aspergillus oryzae
Biosci. Biotechnol. Biochem.
71
2557-2560
2007
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1
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5
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2
2
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5
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1
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8
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1
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1
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1
1
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2
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10
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4
4
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2
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8
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2
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2
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2
2
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680832
Teuscher
The M18 aspartyl aminopeptidas ...
Plasmodium falciparum
J. Biol. Chem.
282
30817-30826
2007
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1
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11
4
1
2
4
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3
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3
1
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1
4
1
1
1
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7
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1
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11
7
4
1
2
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3
1
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1
4
1
1
1
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664909
Yokoyama
Identification of yeast aspart ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae B-8032
FEBS J.
273
192-198
2006
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1
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3
1
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5
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14
2
1
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1
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1
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14
2
1
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1
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680075
Banegas
Plasma aminopeptidase activiti ...
Homo sapiens
Horm. Metab. Res.
38
758-760
2006
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681000
Segarra
Atrial angiotensinase activity ...
Rattus norvegicus
J. Cardiovasc. Pharmacol.
48
117-120
2006
-
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2
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2
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681632
Banegas
Brain aminopeptidases and hype ...
Rattus norvegicus
J. Renin Angiotensin Aldosterone Syst.
7
129-134
2006
-
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1
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1
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2
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663814
Banegas
Angiotensinase activity is asy ...
Rattus norvegicus
Behav. Brain Res.
156
321-326
2005
-
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1
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1
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6
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4
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2
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665074
Adang
-
Aminopeptidase A ...
Mus musculus
Handbook of Proteolytic Enzymes (2nd Edition)
1
299-303
2004
-
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1
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1
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665077
Simmons
-
Aspartyl aminopeptidase ...
Homo sapiens, Mus musculus, Oryctolagus cuniculus
Handbook of Proteolytic Enzymes (2nd Edition)
1
937-939
2004
-
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2
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12
-
3
3
3
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3
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2
3
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4
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21
1
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6
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1
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2
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12
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3
3
3
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2
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4
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21
1
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6
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1
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666534
Gasparello-Clemente
Aminopeptidases in visceral or ...
Rattus norvegicus
Peptides
24
1367-1372
2003
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1
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2
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1
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7
5
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1
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7
5
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1
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1
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649470
Wilk
Identification of histidine re ...
Homo sapiens
Arch. Biochem. Biophys.
407
176-183
2002
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1
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8
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3
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137167
Ramirez-Exposito
Comparative distribution of gl ...
Mus musculus
Horm. Metab. Res.
32
161-163
2000
-
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1
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3
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5
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5
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3
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137168
Wilk
Purification, characterization ...
Homo sapiens, Oryctolagus cuniculus, Rattus sp.
J. Biol. Chem.
273
15961-15970
1998
1
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1
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4
6
2
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2
3
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10
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1
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9
2
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7
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1
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1
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1
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1
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1
6
2
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2
3
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1
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9
2
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7
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1
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137171
Zhang
Biochemical characterization o ...
Salmonella enterica subsp. enterica serovar Typhimurium
Ann. N. Y. Acad. Sci.
864
621-625
1998
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1
1
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3
1
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1
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1
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1
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1
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1
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1
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1
1
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1
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1
1
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1
1
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2
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1
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1
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1
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137169
Iribar
Decrease in cytosolic aspartyl ...
Rattus sp.
Brain Res.
687
211-213
1995
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137170
Nathan
-
Identification and characteriz ...
Escherichia coli
Biochem. Soc. Trans.
17
354
1989
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36021
Danielsen
Proteins of the kidney microvi ...
Sus scrofa
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1980
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