Cloned (Comment) | Organism |
---|---|
gene ape4, located on chromosome 5, sequence comparisons, recombinant expression of GFP-tagged enzyme in Cryptococcus neoformans | Cryptococcus neoformans var. grubii |
Protein Variants | Comment | Organism |
---|---|---|
additional information | random insertional mutagenesis, the ape4 mutants are sensitive to high temperature growth. ape4 Mutation affects multiple virulence factors in Cryptococcus neoformans | Cryptococcus neoformans var. grubii |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Cryptococcus neoformans var. grubii | 5829 | - |
vesicle | Ape4 is localized within the vesicles formed in response to nitrogen starvation and high temperatures. The GFP-Ape4 fusion protein co-localized with intracytoplasmic vesicles during nitrogen depletion | Cryptococcus neoformans var. grubii | 31982 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cryptococcus neoformans var. grubii | J9VNI6 | i.e. Filobasidiella neoformans var. grubii, serotype A | - |
Cryptococcus neoformans var. grubii ATCC 208821 | J9VNI6 | i.e. Filobasidiella neoformans var. grubii, serotype A | - |
Cryptococcus neoformans var. grubii CBS 10515 | J9VNI6 | i.e. Filobasidiella neoformans var. grubii, serotype A | - |
Cryptococcus neoformans var. grubii FGSC 9487 | J9VNI6 | i.e. Filobasidiella neoformans var. grubii, serotype A | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | the APE4 expression pattern is influenced by nitrogen starvation and high temperature, APE4 expression is induced by the combination of nutrient and thermal stress | Cryptococcus neoformans var. grubii | - |
Synonyms | Comment | Organism |
---|---|---|
Ape4 | - |
Cryptococcus neoformans var. grubii |
Ape4 aspartyl aminopeptidase | - |
Cryptococcus neoformans var. grubii |
Ape4 metalloprotease | - |
Cryptococcus neoformans var. grubii |
aspartyl aminopeptidase | - |
Cryptococcus neoformans var. grubii |
CNAG_01169 | - |
Cryptococcus neoformans var. grubii |
Organism | Comment | Expression |
---|---|---|
Cryptococcus neoformans var. grubii | the APE4 expression pattern is influenced by nitrogen starvation and high temperature | additional information |
Cryptococcus neoformans var. grubii | APE4 expression is induced by the combination of nutrient and thermal stress | up |
General Information | Comment | Organism |
---|---|---|
malfunction | a Cryptococcus neoformans ape4 knockout mutant does not grow at 37°C, and also has defects in the expression of important virulence factors such as phospholipase production and capsule formation. The ape4 mutants are sensitive to high temperature growth. ape4 Mutation affects multiple virulence factors in Cryptococcus neoformans | Cryptococcus neoformans var. grubii |
physiological function | Cryptococcus neoformans Ape4 activity is required by facultative intracellular pathogen to survive within macrophages, as well as for virulence in an animal model of cryptococcal infection. The enzyme is involved in autophagy. Cryptococcus neoformans autophagy-related genes are modulated during nitrogen starvation and thermal stress, overview The APE4 gene is involved in multi-stress resistance, aspartyl aminopeptidase encoded by APE4 is important during response to osmotic/salt stress | Cryptococcus neoformans var. grubii |