BRENDA - Enzyme Database show
show all sequences of 3.4.11.21

Aspartyl aminopeptidase

Simmons, W.H.; Handbook of Proteolytic Enzymes (2nd Edition) 1, 937-939 (2004)
No PubMed abstract available

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
DNA and amino acid sequence determination and analysis
Mus musculus
DNA and amino acid sequence determination and analysis, expression in Escherichia coli as His6-tagged enzyme
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
1,10-phenanthroline
complete inhibition
Homo sapiens
1,10-phenanthroline
complete inhibition
Mus musculus
1,10-phenanthroline
complete inhibition
Oryctolagus cuniculus
DTT
high inhibition at 1 mM
Homo sapiens
DTT
high inhibition at 1 mM
Mus musculus
DTT
88% inhibition at 1 mM
Oryctolagus cuniculus
EDTA
weak inhibition
Homo sapiens
EDTA
weak inhibition
Mus musculus
EDTA
weak inhibition
Oryctolagus cuniculus
additional information
no inhibition by Zn2+ in contrary to glutamyl aminopeptidase, EC 3.4.11.7, no inhibition by Glu-thiol, Asp-thiol, bestatin, amastatin, and puromycin
Homo sapiens
additional information
no inhibition by Zn2+ in contrary to glutamyl aminopeptidase, EC 3.4.11.7, no inhibition by Glu-thiol, Asp-thiol, bestatin, amastatin, and puromycin
Mus musculus
additional information
no inhibition by Zn2+ in contrary to glutamyl aminopeptidase, EC 3.4.11.7, no inhibition by Glu-thiol, Asp-thiol, bestatin, amastatin, and puromycin
Oryctolagus cuniculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Homo sapiens
5737
-
cytoplasm
-
Mus musculus
5737
-
cytoplasm
-
Oryctolagus cuniculus
5737
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
additional information
the enzyme is not affected by chloride ions
Homo sapiens
additional information
the enzyme is not affected by chloride ions
Mus musculus
additional information
the enzyme is not affected by chloride ions
Oryctolagus cuniculus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
52428
-
8 * 55000, SDS-PAGE, 8 * 52428, amino acid sequence calculation
Homo sapiens
55000
-
8 * 55000, SDS-PAGE, 8 * 52428, amino acid sequence calculation
Homo sapiens
440000
-
gel filtration
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-
Purification (Commentary)
Commentary
Organism
recombinant His6-tagged enzyme from Escherichia coli by nickel affinity chromatography to homogeneity
Homo sapiens
soluble enzyme from brain to homogeneity by affinity chromatography, gel filtration, hydrophobic interaction and hydroxyapatite chromatography
Oryctolagus cuniculus
Reaction
Reaction
Commentary
Organism
release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate
the conserved residues His94, His170, and His440 are essential for activity
Homo sapiens
release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate
the conserved residues His94, His170, and His440 are essential for activity
Mus musculus
release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate
the conserved residues His94, His170, and His440 are essential for activity
Oryctolagus cuniculus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Oryctolagus cuniculus
-
additional information
broad tissue distribution
Homo sapiens
-
additional information
broad tissue distribution
Mus musculus
-
additional information
broad tissue distribution
Oryctolagus cuniculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
angiotensin II + H2O
i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
665077
Mus musculus
Asp + angiotensin III
i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
-
-
?
angiotensin II + H2O
i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
665077
Homo sapiens
Asp + angiotensin III
i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
-
-
?
angiotensin II + H2O
i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
665077
Oryctolagus cuniculus
Asp + angiotensin III
i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
-
-
?
Asp-Ala-Pro-chromogen + H2O
-
665077
Mus musculus
Asp + Ala-Pro-chromogen
-
-
-
?
Asp-Ala-Pro-chromogen + H2O
-
665077
Homo sapiens
Asp + Ala-Pro-chromogen
-
-
-
?
Asp-Ala-Pro-chromogen + H2O
-
665077
Oryctolagus cuniculus
Asp + Ala-Pro-chromogen
-
-
-
?
Asp-Lys-Ala-Leu + H2O
lower activity
665077
Mus musculus
Asp + Lys-Ala-Leu
-
-
-
?
Asp-Lys-Ala-Leu + H2O
lower activity
665077
Homo sapiens
Asp + Lys-Ala-Leu
-
-
-
?
Asp-Lys-Ala-Leu + H2O
lower activity
665077
Oryctolagus cuniculus
Asp + Lys-Ala-Leu
-
-
-
?
additional information
substrate specificity, overview, the substrate chain length is important for activity, the enzyme has little or no activity towards aminoacyl-arylamines, no or little activity towards aspartyl dipeptides with a positively charged residue in the second position
665077
Mus musculus
?
-
-
-
-
additional information
substrate specificity, overview, the substrate chain length is important for activity, the enzyme has little or no activity towards aminoacyl-arylamines, no or little activity towards aspartyl dipeptides with a positively charged residue in the second position
665077
Homo sapiens
?
-
-
-
-
additional information
substrate specificity, overview, the substrate chain length is important for activity, the enzyme has little or no activity towards aminoacyl-arylamines, no or little activity towards aspartyl dipeptides with a positively charged residue in the second position
665077
Oryctolagus cuniculus
?
-
-
-
-
N-(alpha-L-aspartyl)-4-nitroanilide + H2O
-
665077
Mus musculus
L-aspartic acid + 4-nitroaniline
-
-
-
?
N-(alpha-L-aspartyl)-4-nitroanilide + H2O
-
665077
Homo sapiens
L-aspartic acid + 4-nitroaniline
-
-
-
?
N-(alpha-L-aspartyl)-4-nitroanilide + H2O
-
665077
Oryctolagus cuniculus
L-aspartic acid + 4-nitroaniline
-
-
-
?
N-(alpha-L-glutamyl)-2-naphthylamide + H2O
-
665077
Mus musculus
L-glutamic acid + 2-naphthylamine
-
-
-
?
N-(alpha-L-glutamyl)-2-naphthylamide + H2O
-
665077
Homo sapiens
L-glutamic acid + 2-naphthylamine
-
-
-
?
N-(alpha-L-glutamyl)-2-naphthylamide + H2O
-
665077
Oryctolagus cuniculus
L-glutamic acid + 2-naphthylamine
-
-
-
?
N-(alpha-L-glutamyl)-4-nitroanilide + H2O
-
665077
Mus musculus
L-glutamic acid + 4-nitroaniline
-
-
-
?
N-(alpha-L-glutamyl)-4-nitroanilide + H2O
-
665077
Homo sapiens
L-glutamic acid + 4-nitroaniline
-
-
-
?
N-(alpha-L-glutamyl)-4-nitroanilide + H2O
-
665077
Oryctolagus cuniculus
L-glutamic acid + 4-nitroaniline
-
-
-
?
Subunits
Subunits
Commentary
Organism
octamer
8 * 55000, SDS-PAGE, 8 * 52428, amino acid sequence calculation
Homo sapiens
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
additional information
-
neutral pH-optimum
Homo sapiens
additional information
-
neutral pH-optimum
Mus musculus
additional information
-
neutral pH-optimum
Oryctolagus cuniculus
7.5
-
assay at
Homo sapiens
7.5
-
assay at
Mus musculus
7.5
-
assay at
Oryctolagus cuniculus
pI Value
Organism
Commentary
pI Value Maximum
pI Value
Homo sapiens
sequence calculation
-
7.03
Cloned(Commentary) (protein specific)
Commentary
Organism
DNA and amino acid sequence determination and analysis, expression in Escherichia coli as His6-tagged enzyme
Homo sapiens
DNA and amino acid sequence determination and analysis
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
1,10-phenanthroline
complete inhibition
Homo sapiens
1,10-phenanthroline
complete inhibition
Mus musculus
1,10-phenanthroline
complete inhibition
Oryctolagus cuniculus
DTT
high inhibition at 1 mM
Homo sapiens
DTT
high inhibition at 1 mM
Mus musculus
DTT
88% inhibition at 1 mM
Oryctolagus cuniculus
EDTA
weak inhibition
Homo sapiens
EDTA
weak inhibition
Mus musculus
EDTA
weak inhibition
Oryctolagus cuniculus
additional information
no inhibition by Zn2+ in contrary to glutamyl aminopeptidase, EC 3.4.11.7, no inhibition by Glu-thiol, Asp-thiol, bestatin, amastatin, and puromycin
Homo sapiens
additional information
no inhibition by Zn2+ in contrary to glutamyl aminopeptidase, EC 3.4.11.7, no inhibition by Glu-thiol, Asp-thiol, bestatin, amastatin, and puromycin
Mus musculus
additional information
no inhibition by Zn2+ in contrary to glutamyl aminopeptidase, EC 3.4.11.7, no inhibition by Glu-thiol, Asp-thiol, bestatin, amastatin, and puromycin
Oryctolagus cuniculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Homo sapiens
5737
-
cytoplasm
-
Mus musculus
5737
-
cytoplasm
-
Oryctolagus cuniculus
5737
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
additional information
the enzyme is not affected by chloride ions
Homo sapiens
additional information
the enzyme is not affected by chloride ions
Mus musculus
additional information
the enzyme is not affected by chloride ions
Oryctolagus cuniculus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
52428
-
8 * 55000, SDS-PAGE, 8 * 52428, amino acid sequence calculation
Homo sapiens
55000
-
8 * 55000, SDS-PAGE, 8 * 52428, amino acid sequence calculation
Homo sapiens
440000
-
gel filtration
Homo sapiens
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant His6-tagged enzyme from Escherichia coli by nickel affinity chromatography to homogeneity
Homo sapiens
soluble enzyme from brain to homogeneity by affinity chromatography, gel filtration, hydrophobic interaction and hydroxyapatite chromatography
Oryctolagus cuniculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Oryctolagus cuniculus
-
additional information
broad tissue distribution
Homo sapiens
-
additional information
broad tissue distribution
Mus musculus
-
additional information
broad tissue distribution
Oryctolagus cuniculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
angiotensin II + H2O
i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
665077
Mus musculus
Asp + angiotensin III
i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
-
-
?
angiotensin II + H2O
i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
665077
Homo sapiens
Asp + angiotensin III
i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
-
-
?
angiotensin II + H2O
i.e. Asp-Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
665077
Oryctolagus cuniculus
Asp + angiotensin III
i.e. Tyr-Arg-Val-Tyr-Ile-His-Pro-Phe
-
-
?
Asp-Ala-Pro-chromogen + H2O
-
665077
Mus musculus
Asp + Ala-Pro-chromogen
-
-
-
?
Asp-Ala-Pro-chromogen + H2O
-
665077
Homo sapiens
Asp + Ala-Pro-chromogen
-
-
-
?
Asp-Ala-Pro-chromogen + H2O
-
665077
Oryctolagus cuniculus
Asp + Ala-Pro-chromogen
-
-
-
?
Asp-Lys-Ala-Leu + H2O
lower activity
665077
Mus musculus
Asp + Lys-Ala-Leu
-
-
-
?
Asp-Lys-Ala-Leu + H2O
lower activity
665077
Homo sapiens
Asp + Lys-Ala-Leu
-
-
-
?
Asp-Lys-Ala-Leu + H2O
lower activity
665077
Oryctolagus cuniculus
Asp + Lys-Ala-Leu
-
-
-
?
additional information
substrate specificity, overview, the substrate chain length is important for activity, the enzyme has little or no activity towards aminoacyl-arylamines, no or little activity towards aspartyl dipeptides with a positively charged residue in the second position
665077
Mus musculus
?
-
-
-
-
additional information
substrate specificity, overview, the substrate chain length is important for activity, the enzyme has little or no activity towards aminoacyl-arylamines, no or little activity towards aspartyl dipeptides with a positively charged residue in the second position
665077
Homo sapiens
?
-
-
-
-
additional information
substrate specificity, overview, the substrate chain length is important for activity, the enzyme has little or no activity towards aminoacyl-arylamines, no or little activity towards aspartyl dipeptides with a positively charged residue in the second position
665077
Oryctolagus cuniculus
?
-
-
-
-
N-(alpha-L-aspartyl)-4-nitroanilide + H2O
-
665077
Mus musculus
L-aspartic acid + 4-nitroaniline
-
-
-
?
N-(alpha-L-aspartyl)-4-nitroanilide + H2O
-
665077
Homo sapiens
L-aspartic acid + 4-nitroaniline
-
-
-
?
N-(alpha-L-aspartyl)-4-nitroanilide + H2O
-
665077
Oryctolagus cuniculus
L-aspartic acid + 4-nitroaniline
-
-
-
?
N-(alpha-L-glutamyl)-2-naphthylamide + H2O
-
665077
Mus musculus
L-glutamic acid + 2-naphthylamine
-
-
-
?
N-(alpha-L-glutamyl)-2-naphthylamide + H2O
-
665077
Homo sapiens
L-glutamic acid + 2-naphthylamine
-
-
-
?
N-(alpha-L-glutamyl)-2-naphthylamide + H2O
-
665077
Oryctolagus cuniculus
L-glutamic acid + 2-naphthylamine
-
-
-
?
N-(alpha-L-glutamyl)-4-nitroanilide + H2O
-
665077
Mus musculus
L-glutamic acid + 4-nitroaniline
-
-
-
?
N-(alpha-L-glutamyl)-4-nitroanilide + H2O
-
665077
Homo sapiens
L-glutamic acid + 4-nitroaniline
-
-
-
?
N-(alpha-L-glutamyl)-4-nitroanilide + H2O
-
665077
Oryctolagus cuniculus
L-glutamic acid + 4-nitroaniline
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
octamer
8 * 55000, SDS-PAGE, 8 * 52428, amino acid sequence calculation
Homo sapiens
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
additional information
-
neutral pH-optimum
Homo sapiens
additional information
-
neutral pH-optimum
Mus musculus
additional information
-
neutral pH-optimum
Oryctolagus cuniculus
7.5
-
assay at
Homo sapiens
7.5
-
assay at
Mus musculus
7.5
-
assay at
Oryctolagus cuniculus
pI Value (protein specific)
Organism
Commentary
pI Value Maximum
pI Value
Homo sapiens
sequence calculation
-
7.03
Other publictions for EC 3.4.11.21
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
731109
Lee
Chloride channel ClC-5 binds t ...
Didelphis sp., Rattus norvegicus
Am. J. Physiol. Renal Physiol.
308
F784-F792
2015
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732193
Spicer
Identification of potent and s ...
Plasmodium falciparum
J. Biomol. Screen.
19
1107-1115
2014
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731558
Chaikuad
Structure of human aspartyl am ...
Homo sapiens
BMC Struct. Biol.
12
14
2012
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717822
Yuga
Aspartyl aminopeptidase is imp ...
Saccharomyces cerevisiae
J. Biol. Chem.
286
13704-13713
2011
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1
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708702
Trenholme
Aminopeptidases of malaria par ...
Plasmodium falciparum
Infect. Disord. Drug Targets
10
217-225
2010
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717393
Cai
Aspartyl aminopeptidase, encod ...
Mus musculus
Biosci. Biotechnol. Biochem.
74
2050-2055
2010
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707859
Lee
Aspartyl aminopeptidase of Sch ...
Schizosaccharomyces pombe
BMB Rep.
42
812-816
2009
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1
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1
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