Reference on EC 2.7.7.48 - RNA-directed RNA polymerase and Organism(s) Severe acute respiratory syndrome coronavirus 2 and UniProt Accession P0DTD1
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Morse, J.; Lalonde, T.; Xu, S.; Liu, W.
Learning from the Past Possible urgent prevention and treatment options for severe acute respiratory infections caused by 2019-nCoV
ChemBioChem
21
730-738
2020
Severe acute respiratory syndrome coronavirus 2 (MN908947), Severe acute respiratory syndrome coronavirus 2, Severe acute respiratory syndrome-related coronavirus (P0C6X7)
Dong, S.; Sun, J.; Mao, Z.; Wang, L.; Lu, Y.L.; Li, J.
A guideline for homology modeling of the proteins from newly discovered betacoronavirus, 2019 novel coronavirus (2019-nCoV)
J. Med. Virol.
92
1542-1548
2020
Severe acute respiratory syndrome coronavirus 2 (MN908947), Severe acute respiratory syndrome coronavirus 2
Gordon,C.J.; Tchesnokov,E.P.; Woolner, E.; Perry, J.K.; Feng,J.Y.; Porter, D.P.; Gtte, M.
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency
J. Biol. Chem.
295
6785-6797
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2, Human respiratory syncytial virus A (P28887), Human respiratory syncytial virus A A2 (P28887)
Ahmad, M.; Dwivedy, A.; Mariadasse, R.; Tiwari, S.; Kar, D.; Jeyakanthan, J.; Biswal, B.K.
Prediction of small molecule inhibitors targeting the severe acute respiratory syndrome coronavirus-2 RNA-dependent RNA polymerase
ACS Omega
5
18356-18366
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Jiang, Y.; Yin, W.; Xu, H.E.
RNA-dependent RNA polymerase Structure, mechanism, and drug discovery for COVID-19
Biochem. Biophys. Res. Commun.
538
47-53
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Wang, Q.; Wu, J.; Wang, H.; Gao, Y.; Liu, Q.; Mu, A.; Ji, W.; Yan, L.; Zhu, Y.; Zhu, C.; Fang, X.; Yang, X.; Huang, Y.; Gao, H.; Liu, F.; Ge, J.; Sun, Q.; Yang, X.; Xu, W.; Liu, Z.; Yang, H.; Lou, Z.; Jiang, B.; Guddat, L.W.; Gong, P.; Rao, Z.
Structural basis for RNA replication by the SARS-CoV-2 polymerase
Cell
182
417-428.e13
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Peng, Q.; Peng, R.; Yuan, B.; Zhao, J.; Wang, M.; Wang, X.; Wang, Q.; Sun, Y.; Fan, Z.; Qi, J.; Gao, G.F.; Shi, Y.
Structural and biochemical characterization of the nsp12-nsp7-nsp8 core polymerase complex from SARS-CoV-2
Cell Rep.
31
107774
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Arba, M.; Wahyudi, S.T.; Brunt, D.J.; Paradis, N.; Wu, C.
Mechanistic insight on the remdesivir binding to RNA-dependent RNA polymerase (RdRp) of SARS-cov-2
Comput. Biol. Med.
129
104156
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Agoni, C.; Soliman, M.E.S.
The binding of remdesivir to SARS-CoV-2 RNA-dependent RNA polymerase may pave the way towards the design of potential drugs for COVID-19 treatment
Curr. Pharm. Biotechnol.
22
1520-1537
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Mouffouk, C.; Mouffouk, S.; Mouffouk, S.; Hambaba, L.; Haba, H.
Flavonols as potential antiviral drugs targeting SARS-CoV-2 proteases (3CLpro and PLpro), spike protein, RNA-dependent RNA polymerase (RdRp) and angiotensin-converting enzyme II receptor (ACE2)
Eur. J. Pharmacol.
891
173759
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Baby, K.; Maity, S.; Mehta, C.H.; Suresh, A.; Nayak, U.Y.; Nayak, Y.
Targeting SARS-CoV-2 RNA-dependent RNA polymerase An in silico drug repurposing for COVID-19
F1000Res.
9
1166
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Ao, S.; Han, D.; Sun, L.; Wu, Y.; Liu, S.; Huang, Y.
Identification of potential key agents for targeting RNA-dependent RNA polymerase of SARS-CoV-2 by integrated analysis and virtual drug screening
Front. Genet.
11
581668
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Parvez, M.S.A.; Karim, M.A.; Hasan, M.; Jaman, J.; Karim, Z.; Tahsin, T.; Hasan, M.N.; Hosen, M.J.
Prediction of potential inhibitors for RNA-dependent RNA polymerase of SARS-CoV-2 using comprehensive drug repurposing and molecular docking approach
Int. J. Biol. Macromol.
163
1787-1797
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Pormohammad, A.; Monych, N.K.; Turner, R.J.
Zinc and SARS-CoV-2 A molecular modeling study of Zn interactions with RNA-dependent RNA-polymerase and 3C-like proteinase enzymes
Int. J. Mol. Med.
47
326-334
2021
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Dangerfield, T.L.; Huang, N.Z.; Johnson, K.A.
Remdesivir is effective in combating COVID-19 because it is a better substrate than ATP for the viral RNA-dependent RNA polymerase
iScience
23
101849
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Babadaei, M.M.N.; Hasan, A.; Vahdani, Y.; Bloukh, S.H.; Sharifi, M.; Kachooei, E.; Haghighat, S.; Falahati, M.
Development of remdesivir repositioning as a nucleotide analog against COVID-19 RNA dependent RNA polymerase
J. Biomol. Struct. Dyn.
2020
1-9
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Gul, S.; Ozcan, O.; Asar, S.; Okyar, A.; Baris, I.; Kavakli, I.H.
In silico identification of widely used and well-tolerated drugs as potential SARS-CoV-2 3C-like protease and viral RNA-dependent RNA polymerase inhibitors for direct use in clinical trials
J. Biomol. Struct. Dyn.
39
6772-6791
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Huang, J.; Song, W.; Huang, H.; Sun, Q.
Pharmacological therapeutics targeting RNA-dependent RNA polymerase, proteinase and spike protein from mechanistic studies to clinical trials for COVID-19
J. Clin. Med.
9
1131
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Pokhrel, R.; Chapagain, P.; Siltberg-Liberles, J.
Potential RNA-dependent RNA polymerase inhibitors as prospective therapeutics against SARS-CoV-2
J. Med. Microbiol.
69
864-873
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Chien, M.; Anderson, T.K.; Jockusch, S.; Tao, C.; Li, X.; Kumar, S.; Russo, J.J.; Kirchdoerfer, R.N.; Ju, J.
Nucleotide analogues as inhibitors of SARS-CoV-2 polymerase, a key drug target for COVID-19
J. Proteome Res.
19
4690-4697
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Zhao, Z.; Bourne, P.E.
Structural insights into the binding modes of viral RNA-dependent RNA polymerases using a function-site interaction fingerprint method for RNA virus drug discovery
J. Proteome Res.
19
4698-4705
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Buonaguro, L.; Tagliamonte, M.; Tornesello, M.L.; Buonaguro, F.M.
SARS-CoV-2 RNA polymerase as target for antiviral therapy
J. Transl. Med.
18
185
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Aftab, S.O.; Ghouri, M.Z.; Masood, M.U.; Haider, Z.; Khan, Z.; Ahmad, A.; Munawar, N.
Analysis of SARS-CoV-2 RNA-dependent RNA polymerase as a potential therapeutic drug target using a computational approach
J. Transl. Med.
18
275
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Gharbi-Ayachi, A.; Santhanakrishnan, S.; Wong, Y.H.; Chan, K.W.K.; Tan, S.T.; Bates, R.W.; Vasudevan, S.G.; El Sahili, A.; Lescar, J.
Non-nucleoside inhibitors of Zika Virus RNA-dependent RNA polymerase
J. Virol.
94
e00794-20
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1)
Elfiky, A.A.
Ribavirin, remdesivir, sofosbuvir, galidesivir, and tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp) A molecular docking study
Life Sci.
253
117592
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Shannon, A.; Selisko, B.; Le, N.T.; Huchting, J.; Touret, F.; Piorkowski, G.; Fattorini, V.; Ferron, F.; Decroly, E.; Meier, C.; Coutard, B.; Peersen, O.; Canard, B.
Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis
Nat. Commun.
11
4682
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Hillen, H.S.; Kokic, G.; Farnung, L.; Dienemann, C.; Tegunov, D.; Cramer, P.
Structure of replicating SARS-CoV-2 polymerase
Nature
584
154-156
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Chand, G.B.; Banerjee, A.; Azad, G.K.
Identification of novel mutations in RNA-dependent RNA polymerases of SARS-CoV-2 and their implications on its protein structure
PeerJ
8
e9492
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Ju, J.; Li, X.; Kumar, S.; Jockusch, S.; Chien, M.; Tao, C.; Morozova, I.; Kalachikov, S.; Kirchdoerfer, R.N.; Russo, J.J.
Nucleotide analogues as inhibitors of SARS-CoV polymerase
Pharmacol. Res. Perspect.
8
e00674
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Yin, W.; Mao, C.; Luan, X.; Shen, D.D.; Shen, Q.; Su, H.; Wang, X.; Zhou, F.; Zhao, W.; Gao, M.; Chang, S.; Xie, Y.C.; Tian, G.; Jiang, H.W.; Tao, S.C.; Shen, J.; Jiang, Y.; Jiang, H.; Xu, Y.; Zhang, S.; Zhang, Y.; Xu, H.E.
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
Science
368
1499-1504
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
Gao, Y.; Yan, L.; Huang, Y.; Liu, F.; Zhao, Y.; Cao, L.; Wang, T.; Sun, Q.; Ming, Z.; Zhang, L.; Ge, J.; Zheng, L.; Zhang, Y.; Wang, H.; Zhu, Y.; Zhu, C.; Hu, T.; Hua, T.; Zhang, B.; Yang, X.; Li, J.; Yang, H.; Liu, Z.; Xu, W.; Guddat, L.W.; Wang, Q.; Lou, Z.; Rao, Z.
Structure of the RNA-dependent RNA polymerase from COVID-19 virus
Science
368
779-782
2020
Severe acute respiratory syndrome coronavirus 2 (P0DTD1), Severe acute respiratory syndrome coronavirus 2
