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Literature summary for 2.7.7.48 extracted from

  • Zhao, Z.; Bourne, P.E.
    Structural insights into the binding modes of viral RNA-dependent RNA polymerases using a function-site interaction fingerprint method for RNA virus drug discovery (2020), J. Proteome Res., 19, 4698-4705 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nucleoside triphosphate + RNAn Severe acute respiratory syndrome coronavirus 2
-
 diphosphate + RNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Severe acute respiratory syndrome coronavirus 2 P0DTD1 replicase polyprotein 1ab; SARS-CoV-2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nucleoside triphosphate + RNAn
-
 Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
-
 ?

Synonyms

Synonyms Comment Organism
RDRP
-
 Severe acute respiratory syndrome coronavirus 2
RNA-dependent RNA polymerase
-
 Severe acute respiratory syndrome coronavirus 2

General Information

General Information Comment Organism
drug target the structural characteristics of the catalytic domain of the RNA-dependent RNA polymerase are explored using a computational pharmacology method. Ligand-binding characteristics of the binding site are determined using a receptor-ligand function-site interaction fingerprint strategy. Binding characteristics determined by this method help to rationalize RNA-dependent RNA polymerase-targeted drug discovery and provide insights into the specific binding mechanisms important for containing the SARS-CoV-2 virus Severe acute respiratory syndrome coronavirus 2