Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
nucleoside triphosphate + RNAn | Severe acute respiratory syndrome coronavirus 2 | - |
diphosphate + RNAn+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Severe acute respiratory syndrome coronavirus 2 | P0DTD1 | replicase polyprotein 1ab; SARS-CoV-2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
nucleoside triphosphate + RNAn | - |
Severe acute respiratory syndrome coronavirus 2 | diphosphate + RNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RDRP | - |
Severe acute respiratory syndrome coronavirus 2 |
RNA-dependent RNA polymerase | - |
Severe acute respiratory syndrome coronavirus 2 |
General Information | Comment | Organism |
---|---|---|
drug target | FDA approved library of drugs are docked against the active site of the enzyme (RdRp) using Schrodinger's computer-aided drug discovery tools for in silico drug-repurposing. In molecular dynamics simulations, pitavastatin, ridogrel and rosoxacin displayed superior binding with the active site through Arg555 and Mg2+ | Severe acute respiratory syndrome coronavirus 2 |