Literature summary for 2.7.7.48 extracted from

Chien, M.; Anderson, T.K.; Jockusch, S.; Tao, C.; Li, X.; Kumar, S.; Russo, J.J.; Kirchdoerfer, R.N.; Ju, J.
Nucleotide analogues as inhibitors of SARS-CoV-2 polymerase, a key drug target for COVID-19 (2020), J. Proteome Res., 19, 4690-4697 .

Search for more literature for 2.7.7.48

Cloned(Commentary)

Cloned (Comment)	Organism
expression of SARS-CoV-2 nsp12 in Sf9 cells. Expression of SARS-CoV-2 nsp7 and nsp8 in Escherichia coli	Severe acute respiratory syndrome coronavirus 2

Inhibitors

Inhibitors	Comment	Organism	Structure
alovudine triphosphate	-	Severe acute respiratory syndrome coronavirus 2
azidothymidin triphosphate	-	Severe acute respiratory syndrome coronavirus 2
carbovir triphosphate	-	Severe acute respiratory syndrome coronavirus 2
sofosbuvir triphosphate	-	Severe acute respiratory syndrome coronavirus 2
tenofovir triphosphate	-	Severe acute respiratory syndrome coronavirus 2

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
nucleoside triphosphate + RNAn	Severe acute respiratory syndrome coronavirus 2	-	diphosphate + RNAn+1	-	?

Organism

Organism	UniProt	Comment	Textmining
Severe acute respiratory syndrome coronavirus 2	P0DTD1	replicase polyprotein 1ab; SARS-CoV-2	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
nucleoside triphosphate + RNAn	-	Severe acute respiratory syndrome coronavirus 2	diphosphate + RNAn+1	-	?

Synonyms

Synonyms	Comment	Organism
RDRP	-	Severe acute respiratory syndrome coronavirus 2
RNA-dependent RNA polymerase	-	Severe acute respiratory syndrome coronavirus 2

General Information

General Information	Comment	Organism
drug target	SARS-CoV-2 polymerase is a key drug target for COVID-19	Severe acute respiratory syndrome coronavirus 2

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)