Literature summary for 2.7.7.48 extracted from

Ahmad, M.; Dwivedy, A.; Mariadasse, R.; Tiwari, S.; Kar, D.; Jeyakanthan, J.; Biswal, B.K.
Prediction of small molecule inhibitors targeting the severe acute respiratory syndrome coronavirus-2 RNA-dependent RNA polymerase (2020), ACS Omega, 5, 18356-18366 .

Search for more literature for 2.7.7.48

Organism

Organism	UniProt	Comment	Textmining
Severe acute respiratory syndrome coronavirus 2	P0DTD1	SARS-CoV-2	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
nucleoside triphosphate + RNAn	-	Severe acute respiratory syndrome coronavirus 2	diphosphate + RNAn+1	-	?

Synonyms

Synonyms	Comment	Organism
RDRP	-	Severe acute respiratory syndrome coronavirus 2
RNA-dependent RNA polymerase	-	Severe acute respiratory syndrome coronavirus 2

Cofactor

Cofactor	Comment	Organism	Structure
GTP	GTP is crucial for the formation of the initiation complex during RNA replication. The 3D structure of the RdRp (RNA-dependent RNA polymerase) of SARS-CoV2 is modelled its probable GTP binding pocket in the active site is predicted	Severe acute respiratory syndrome coronavirus 2

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)