Inhibitors | Comment | Organism | Structure |
---|---|---|---|
remdesivir triphosphate | the structures of the enzyme in complex with RNA helical strands and remdesivir provide the structure details of RdRp inhibition by remdesivir. The inhibitor competes with the incorporation of nucleotide counterparts and inhibits transcription of viral RNA. The inhibition mechanism of remdesivir is a delayed chain termination of nascent viral RNA at i+3 position | Severe acute respiratory syndrome coronavirus 2 |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
nucleoside triphosphate + RNAn | Severe acute respiratory syndrome coronavirus 2 | essential enzyme for viral RNA replication | diphosphate + RNAn+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Severe acute respiratory syndrome coronavirus 2 | P0DTD1 | replicase polyprotein 1ab; SARS-CoV-2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
nucleoside triphosphate + RNAn | - |
Severe acute respiratory syndrome coronavirus 2 | diphosphate + RNAn+1 | - |
? | |
nucleoside triphosphate + RNAn | essential enzyme for viral RNA replication | Severe acute respiratory syndrome coronavirus 2 | diphosphate + RNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RDRP | - |
Severe acute respiratory syndrome coronavirus 2 |
RNA-dependent RNA polymerase | - |
Severe acute respiratory syndrome coronavirus 2 |
General Information | Comment | Organism |
---|---|---|
drug target | drug target for COVID-19 | Severe acute respiratory syndrome coronavirus 2 |
physiological function | essential enzyme for viral RNA replication | Severe acute respiratory syndrome coronavirus 2 |