Literature summary for 2.7.7.48 extracted from

Gao, Y.; Yan, L.; Huang, Y.; Liu, F.; Zhao, Y.; Cao, L.; Wang, T.; Sun, Q.; Ming, Z.; Zhang, L.; Ge, J.; Zheng, L.; Zhang, Y.; Wang, H.; Zhu, Y.; Zhu, C.; Hu, T.; Hua, T.; Zhang, B.; Yang, X.; Li, J.; Yang, H.; Liu, Z.; Xu, W.; Guddat, L.W.; Wang, Q.; Lou, Z.; Rao, Z.
Structure of the RNA-dependent RNA polymerase from COVID-19 virus (2020), Science, 368, 779-782 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	cryo-electron microscopy structure of COVID-19 virus full-length nsp12 in complex with cofactors nsp7 and nsp8 at 2.9 A resolution provides a basis for the design of new antiviral therapeutics that target viral RNA-dependent RNA polymerase	Severe acute respiratory syndrome coronavirus 2
remdesivir	cryo-electron microscopy structure of COVID-19 virus full-length nsp12 in complex with cofactors nsp7 and nsp8 at 2.9 A resolution. A comparative analysis model shows how remdesivir binds to this polymerase	Severe acute respiratory syndrome coronavirus 2

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
nucleoside triphosphate + RNAn	Severe acute respiratory syndrome coronavirus 2	-	diphosphate + RNAn+1	-	?

Organism

Organism	UniProt	Comment	Textmining
Severe acute respiratory syndrome coronavirus 2	P0DTD1	replicase polyprotein 1ab; SARS-CoV-2	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
nucleoside triphosphate + RNAn	-	Severe acute respiratory syndrome coronavirus 2	diphosphate + RNAn+1	-	?

Subunits

Subunits	Comment	Organism
More	cryo-electron microscopy structure of COVID-19 virus full-length nsp12 in complex with cofactors nsp7 and nsp8 at 2.9 A resolution	Severe acute respiratory syndrome coronavirus 2

Synonyms

Synonyms	Comment	Organism
nsp12	-	Severe acute respiratory syndrome coronavirus 2
RDRP	-	Severe acute respiratory syndrome coronavirus 2
RNA-dependent RNA polymerase	-	Severe acute respiratory syndrome coronavirus 2

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Release 2023.1 (January 2023)