Reference on EC 2.7.11.18 - myosin-light-chain kinase and Organism(s) Homo sapiens and UniProt Accession Q15746
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (Q15746)
Deloukas, P.; Matthews, L.H.; Ashurst, J.; Burton, J.; Gilbert, J.G.; et al.
The DNA sequence and comparative analysis of human chromosome 20
Nature
414
865-871
2001
Homo sapiens (Q9H1R3)
Davis, J.S.; Hassanzadeh, S.; Winitsky, S.; Lin, H.; Satorius, C.; Vemuri, R.; Aletras, A.H.; Wen, H.; Epstein, N.D.
The overall pattern of cardiac contraction depends on a spatial gradient of myosin regulatory light chain phosphorylation
Cell
107
631-641
2001
Oryctolagus cuniculus (P07313), Homo sapiens (Q9H1R3), Homo sapiens
Garcia, J.G.N.; Lazar, V.; Gilbert-McClain, L.I.; Gallagher, P.J.; Verin, A.D.
Myosin light chain kinase in endothelium: molecular cloning and regulation
Am. J. Respir. Cell Mol. Biol.
16
489-494
1997
Bos taurus, Homo sapiens, Homo sapiens (Q15746)
Lazar, V.; Garcia, J.G.
A single human myosin light chain kinase gene (MLCK; MYLK)
Genomics
57
256-267
1999
Homo sapiens (Q15746), Homo sapiens
Potier, M.C.; Chelot, E.; Pekarsky, Y.; Gardiner, K.; Rossier, J.; Turnell, W.G.
The human myosin light chain kinase (MLCK) from hippocampus: cloning, sequencing, expression, and localization to 3qcen-q21
Genomics
29
562-570
1995
Homo sapiens (Q15746), Homo sapiens
Watterson, D.M.; Schavocky, J.P.; Guo, L.; Weiss, C.; Chlenski, A.; Shirinsky, V.P.; Van Eldik, L.J.; Haiech, J.
Analysis of the kinase-related protein gene found at human chromosome 3q21 in a multi-gene cluster: organization, expression, alternative splicing, and polymorphic marker
J. Cell. Biochem.
75
481-491
1999
Homo sapiens (Q15746), Homo sapiens
Hathaway, D.R.; Adelstein, R.S.
Human platelet myosin light chain kinase requires the calcium-binding protein calmodulin for activity
Proc. Natl. Acad. Sci. USA
76
1653-1657
1979
Homo sapiens
Pato, M.D.; Lye, S.J.; Kerc, E.
Purification and characterization of pregnant sheep myometrium myosin light chain kinase
Arch. Biochem. Biophys.
287
24-32
1991
Ovis aries, Homo sapiens, Meleagris gallopavo
Adelstein, R.S.; Klee, C.B.
Purification of smooth muscle myosin light-chain kinase
Methods Enzymol.
85
298-308
1982
Homo sapiens, Meleagris gallopavo
-
Conti, M.A.; Adelstein, R.S.
Purification and properties of myosin light chain kinases
Methods Enzymol.
196
34-47
1991
Bos taurus, Oryctolagus cuniculus, Homo sapiens, Meleagris gallopavo, Rattus norvegicus, Sus scrofa
Stull, J.T.; Nunnally, M.H.; Michnoff, C.H in
Calmoduline-dependent protein kinases
The Enzymes, 3rd. Ed. (Boyer, P. D. , Krebs, E. G. , eds. )
17
113-166
1986
Bos taurus, Canis lupus familiaris, Cavia porcellus, Gallus gallus, Homo sapiens, Meleagris gallopavo, Rattus norvegicus
-
Verin, A.D.; Gilbert-McClain, L.I.; Patterson, C.E.; Garcia, J.G.N.
Biochemical regulation of the nonmuscle myosin light chain kinase isoform in bovine endothelium
Am. J. Respir. Cell Mol. Biol.
19
767-776
1998
Bos taurus, Homo sapiens
Dudek, S.M.; Birukov, K.G.; Zhan, X.; Garcia, J.G.N.
Novel interaction of cortactin with endothelial cell myosin light chain kinase
Biochem. Biophys. Res. Commun.
298
511-519
2002
Homo sapiens
Grimm, M.; Haas, P.; Willipinski-Stapelfeldt, B.; Zimmermann, W.H.; Rau, T.; Pantel, K.; Weyand, M.; Eschenhagen, T.
Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the alpha 1-adrenergic positive inotropic effect in human atrium
Cardiovasc. Res.
65
211-220
2005
Homo sapiens
Dulyaninova, N.G.; Bresnick, A.R.
The long myosin light chain kinase is differentially phosphorylated during interphase and mitosis
Exp. Cell Res.
299
303-314
2004
Oryctolagus cuniculus, Homo sapiens
Geguchadze, R.; Zhi, G.; Lau, K.S.; Isotani, E.; Persechini, A.; Kamm, K.E.; Stull, J.T.
Quantitative measurements of Ca(2+)/calmodulin binding and activation of myosin light chain kinase in cells
FEBS Lett.
557
121-124
2004
Homo sapiens
Adachi, T.; Stafford, S.; Kayaba, H.; Chihara, J.; Alam, R.
Myosin light chain kinase mediates eosinophil chemotaxis in a mitogen-activated protein kinase-dependent manner
J. Allergy Clin. Immunol.
111
113-116
2003
Homo sapiens
Clayburgh, D.R.; Rosen, S.; Witkowski, E.D.; Wang, F.; Blair, S.; Dudek, S.; Garcia, J.G.; Alverdy, J.C.; Turner, J.R.
A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability
J. Biol. Chem.
279
55506-55513
2004
Homo sapiens (Q15746)
Wadgaonkar, R.; Nurmukhambetova, S.; Zaiman, A.L.; Garcia, J.G.
Mutation analysis of the non-muscle myosin light chain kinase (MLCK) deletion constructs on CV1 fibroblast contractile activity and proliferation
J. Cell. Biochem.
88
623-634
2003
Homo sapiens
Wadgaonkar, R.; Linz-McGillem, L.; Zaiman, A.L.; Garcia, J.G.
Endothelial cell myosin light chain kinase (MLCK) regulates TNFalpha-induced NFkappaB activity
J. Cell. Biochem.
94
351-364
2005
Homo sapiens
Wadgaonkar, R.; Dudek, S.M.; Zaiman, A.L.; Linz-McGillem, L.; Verin, A.D.; Nurmukhambetova, S.; Romer, L.H.; Garcia, J.G.
Intracellular interaction of myosin light chain kinase with macrophage migration inhibition factor (MIF) in endothelium
J. Cell. Biochem.
95
849-858
2005
Homo sapiens
Tinsley, J.H.; Yuan, S.Y.; Wilson, E.
Isoform-specific knockout of endothelial myosin light chain kinase: closing the gap on inflammatory lung disease
Trends Pharmacol. Sci.
25
64-66
2004
Homo sapiens, Mus musculus
Zhu, H.Q.; Wang, Y.; Hu, R.L.; Ren, B.; Zhou, Q.; Jiang, Z.K.; Gui, S.Y.
Distribution and expression of non-muscle myosin light chain kinase in rabbit livers
World J. Gastroenterol.
9
2715-2719
2003
Homo sapiens, Oryctolagus cuniculus
Niggli, V.; Schmid, M.; Nievergelt, A.
Differential roles of Rho-kinase and myosin light chain kinase in regulating shape, adhesion, and migration of HT1080 fibrosarcoma cells
Biochem. Biophys. Res. Commun.
343
602-608
2006
Homo sapiens
Dudnakova, T.V.; Stepanova, O.V.; Dergilev, K.V.; Chadin, A.V.; Shekhonin, B.V.; Watterson, D.M.; Shirinsky, V.P.
Myosin light chain kinase colocalizes with nonmuscle myosin IIB in myofibril precursors and sarcomeric Z-lines of cardiomyocytes
Cell Motil. Cytoskeleton
63
375-383
2006
Gallus gallus, Homo sapiens
Seguchi, O.; Takashima, S.; Yamazaki, S.; Asakura, M.; Asano, Y.; Shintani, Y.; Wakeno, M.; Minamino, T.; Kondo, H.; Furukawa, H.; Nakamaru, K.; Naito, A.; Takahashi, T.; Ohtsuka, T.; Kawakami, K.; Isomura, T.; Kitamura, S.; Tomoike, H.; Mochizuki, N.; Kitakaze, M.
A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart
J. Clin. Invest.
117
2812-2824
2007
Danio rerio, Homo sapiens
Afonso, P.V.; Ozden, S.; Prevost, M.C.; Schmitt, C.; Seilhean, D.; Weksler, B.; Couraud, P.O.; Gessain, A.; Romero, I.A.; Ceccaldi, P.E.
Human blood-brain barrier disruption by retroviral-infected lymphocytes: role of myosin light chain kinase in endothelial tight-junction disorganization
J. Immunol.
179
2576-2583
2007
Homo sapiens
Shimizu, S.; Yoshida, T.; Wakamori, M.; Ishii, M.; Okada, T.; Takahashi, M.; Seto, M.; Sakurada, K.; Kiuchi, Y.; Mori, Y.
Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells
J. Physiol.
570
219-235
2006
Homo sapiens (Q15746), Homo sapiens (Q9H1R3), Homo sapiens
Blair, S.A.; Kane, S.V.; Clayburgh, D.R.; Turner, J.R.
Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease
Lab. Invest.
86
191-201
2006
Homo sapiens
Zhou, X.; Liu, Y.; You, J.; Zhang, H.; Zhang, X.; Ye, L.
Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2
Cancer Lett.
270
312-327
2008
Homo sapiens (Q15746)
Christie, J.D.; Ma, S.F.; Aplenc, R.; Li, M.; Lanken, P.N.; Shah, C.V.; Fuchs, B.; Albelda, S.M.; Flores, C.; Garcia, J.G.
Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma
Crit. Care Med.
36
2794-2800
2008
Homo sapiens
Borisov, A.B.; Raeker, M.O.; Russell, M.W.
Developmental expression and differential cellular localization of obscurin and obscurin-associated kinase in cardiac muscle cells
J. Cell. Biochem.
103
1621-1635
2008
Homo sapiens, Mus musculus, Rattus norvegicus
Chilcoat, C.D.; Sharief, Y.; Jones, S.L.
Tonic protein kinase A activity maintains inactive beta2 integrins in unstimulated neutrophils by reducing myosin light-chain phosphorylation: role of myosin light-chain kinase and Rho kinase
J. Leukoc. Biol.
83
964-971
2008
Homo sapiens
Zhu, H.Q.; Cheng, X.W.; Xiao, L.L.; Jiang, Z.K.; Zhou, Q.; Gui, S.Y.; Wei, W.; Wang, Y.
Melatonin prevents oxidized low-density lipoprotein-induced increase of myosin light chain kinase activation and expression in HUVEC through ERK/MAPK signal transduction
J. Pineal Res.
45
328-334
2008
Homo sapiens
Feighery, L.M.; Cochrane, S.W.; Quinn, T.; Baird, A.W.; OToole, D.; Owens, S.E.; ODonoghue, D.; Mrsny, R.J.; Brayden, D.J.
Myosin light chain kinase inhibition: correction of increased intestinal epithelial permeability in vitro
Pharm. Res.
25
1377-1386
2008
Homo sapiens, Mus musculus, Mus musculus C57BL/6, Rattus norvegicus
Moitra, J.; Evenoski, C.; Sammani, S.; Wadgaonkar, R.; Turner, J.R.; Ma, S.F.; Garcia, J.G.
A transgenic mouse with vascular endothelial over-expression of the non-muscle myosin light chain kinase-2 isoform is susceptible to inflammatory lung injury: role of sexual dimorphism and age
Transl. Res.
151
141-153
2008
Homo sapiens
Leguillette, R.; Laviolette, M.; Bergeron, C.; Zitouni, N.; Kogut, P.; Solway, J.; Kachmar, L.; Hamid, Q.; Lauzon, A.M.
Myosin, transgelin, and myosin light chain kinase: expression and function in asthma
Am. J. Respir. Crit. Care Med.
179
194-204
2009
Homo sapiens
Ye, D.; Ma, T.Y.
Cellular and molecular mechanisms that mediate basal and tumour necrosis factor-alpha-induced regulation of myosin light chain kinase gene activity
J. Cell. Mol. Med.
12
1331-1346
2008
Homo sapiens
Miyauchi, E.; Morita, H.; Tanabe, S.
Lactobacillus rhamnosus alleviates intestinal barrier dysfunction in part by increasing expression of zonula occludens-1 and myosin light-chain kinase in vivo
J. Dairy Sci.
92
2400-2408
2009
Homo sapiens, Mus musculus
Leveille, N.; Fournier, A.; Labrie, C.
Androgens down-regulate myosin light chain kinase in human prostate cancer cells
J. Steroid Biochem. Mol. Biol.
114
174-179
2009
Homo sapiens
Brown, M.; Adyshev, D.; Bindokas, V.; Moitra, J.; Garcia, J.G.; Dudek, S.M.
Quantitative distribution and colocalization of non-muscle myosin light chain kinase isoforms and cortactin in human lung endothelium
Microvasc. Res.
80
75-88
2010
Homo sapiens
Shin, D.H.; Chun, Y.S.; Lee, K.H.; Shin, H.W.; Park, J.W.
Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinase
PLoS ONE
4
e7451
2009
Homo sapiens
Hong, F.; Brizendine, R.K.; Carter, M.S.; Alcala, D.B.; Brown, A.E.; Chattin, A.M.; Haldeman, B.D.; Walsh, M.P.; Facemyer, K.C.; Baker, J.E.; Cremo, C.R.
Diffusion of myosin light chain kinase on actin: A mechanism to enhance myosin phosphorylation rates in smooth muscle
J. Gen. Physiol.
146
267-280
2015
Homo sapiens (Q15746)
Shen, K.; Ramirez, B.; Mapes, B.; Shen, G.R.; Gokhale, V.; Brown, M.E.; Santarsiero, B.; Ishii, Y.; Dudek, S.M.; Wang, T.; Garcia, J.G.
Structure-function analysis of the non-muscle myosin light chain kinase (nmMLCK) isoform by NMR spectroscopy and molecular modeling: influence of MYLK variants
PLoS ONE
10
e0130515
2015
Homo sapiens
Watari, A.; Sakamoto, Y.; Hisaie, K.; Iwamoto, K.; Fueta, M.; Yagi, K.; Kondoh, M.
Rebeccamycin attenuates TNF-alpha-induced intestinal epithelial barrier dysfunction by inhibiting myosin light chain kinase production
Cell. Physiol. Biochem.
41
1924-1934
2017
Homo sapiens
Burbank, M.G.; Burban, A.; Sharanek, A.; Weaver, R.J.; Guguen-Guillouzo, C.; Guillouzo, A.
Early alterations of bile canaliculi dynamics and the Rho kinase/myosin light chain kinase pathway are characteristics of drug-induced intrahepatic cholestasis
Drug Metab. Dispos.
44
1780-1793
2016
Homo sapiens
Pai, Y.C.; Weng, L.T.; Wei, S.C.; Wu, L.L.; Shih, D.Q.; Targan, S.R.; Turner, J.R.; Yu, L.C.
Gut microbial transcytosis induced by tumor necrosis factor-like 1A-dependent activation of a myosin light chain kinase splice variant contributes to inflammatory bowel disease
J. Crohns Colitis
2021
258-272
2020
Homo sapiens (Q15746), Homo sapiens (Q9H1R3), Homo sapiens
