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Literature summary for 2.7.11.18 extracted from

  • Pai, Y.C.; Weng, L.T.; Wei, S.C.; Wu, L.L.; Shih, D.Q.; Targan, S.R.; Turner, J.R.; Yu, L.C.
    Gut microbial transcytosis induced by tumor necrosis factor-like 1A-dependent activation of a myosin light chain kinase splice variant contributes to inflammatory bowel disease (2020), J. Crohns Colitis, 2021, 258-272 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.18

Activating Compound

Activating Compound Comment Organism Structure
tumor necrosis factor-like 1A
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride inhibitor targeting the ATPase domain of the enzyme; inhibitor targeting the ATPase domain of the enzyme Homo sapiens
RKKYKYRRK-NH2 specific enzyme inhibitor targeting the kinase domain; specific enzyme inhibitor targeting the kinase domain Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
210000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [myosin light chain] Homo sapiens
-
 ADP + [myosin light chain] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q15746
-
-
Homo sapiens Q9H1R3
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
-
 Homo sapiens
-
intestinal epithelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [myosin light chain]
-
 Homo sapiens ADP + [myosin light chain] phosphate
-
 ?

Synonyms

Synonyms Comment Organism
MLCK1 isoform Homo sapiens
MLCK2 isoform Homo sapiens

Expression

Organism Comment Expression
Homo sapiens interferon gamma does not upregulate isoform MLCK1 transcript additional information
Homo sapiens the expression level of the splice variant MLCK1 is significantly increased in actively inflamed tissues of the Crohn's disease and ulcerative colitis patient samples. The splice variant MLCK1 is overexpressed in colonic biopsy specimens of inflammatory bowel disease patients. Treatment with low-dose cytokines tumor necrosis factor-like 1A up
Homo sapiens the expression levels of splice variant MLCK2 is significantly increased in actively inflamed tissues of the Crohn's disease and ulcerative colitis patient samples. The splice variant MLCK2 is overexpressed in colonic biopsy specimens of inflammatory bowel disease patients. Treatment with low-dose cytokines tumour necrosis factor-like 1A and interferon gamma upregulates isoform MLCK2 transcript up