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Literature summary for 2.7.11.18 extracted from

  • Blair, S.A.; Kane, S.V.; Clayburgh, D.R.; Turner, J.R.
    Epithelial myosin light chain kinase expression and activity are upregulated in inflammatory bowel disease (2006), Lab. Invest., 86, 191-201.
    View publication on PubMed
Search for more literature for 2.7.11.18

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + light chain myosin II Homo sapiens cytokine-induced epithelial barrier dysfunction can be mediated by increased MLCK expression and subsequent myosin II regulatory light chain phosphorylation, the enzyme is involved in the inflammatory bowel disease ADP + phosphorylated light chain myosin II
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 ?
additional information Homo sapiens increased MLCK activity accompanies increases in MLC expression, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colon epithelium Homo sapiens
-
epithelium
-
 Homo sapiens
-
ileum ileal epithelial MLCK expression is mildly upregulated in inactive inflammatory bowel disease, and highly upregulated in active IBD Homo sapiens
-
intestine epithelium, expression of MLVK is upregulated by inflammatory bowel disease Homo sapiens
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additional information tissue dependent MLCK expression analysis of 26 inflammatory bowel disease patients Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + light chain myosin II cytokine-induced epithelial barrier dysfunction can be mediated by increased MLCK expression and subsequent myosin II regulatory light chain phosphorylation, the enzyme is involved in the inflammatory bowel disease Homo sapiens ADP + phosphorylated light chain myosin II
-
 ?
ATP + light chain myosin II regulatory myosin light chain Homo sapiens ADP + phosphorylated light chain myosin II
-
 ?
additional information increased MLCK activity accompanies increases in MLC expression, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MLCK
-
 Homo sapiens
myosin light chain kinase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens