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Literature summary for 2.7.11.18 extracted from
- Myosin light chain kinase mediates eosinophil chemotaxis in a mitogen-activated protein kinase-dependent manner (2003), J. Allergy Clin. Immunol., 111, 113-116.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| eotaxin | activates the enzyme 4fold, induces enzyme phosphorylation | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ML-7 | specific inhibitor, inhibits activation by eotaxin | Homo sapiens |  |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Homo sapiens | |
| Mg2+ | - |
Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 150000 | - |
- |
Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [myosin light chain] | Homo sapiens | enzyme is regulating cytoskeletal rearrangement and cell motility | ADP + [myosin light chain] phosphate | - |
? | |
| additional information | Homo sapiens | the enzyme mediates eosinophil chemotaxis in a mitogen-activated protein kinase-dependent manner | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | eotaxin induces enzyme phosphorylation by serine/threonine protein kinases e.g. by MAP kinases ERK1/2 and p38 at Thr43, phosphorylation is required for activation of the enzyme | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partially from eosinophils | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| eosinophil | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H-KKRAARATSNVFA-NH2 | peptide substrate | Homo sapiens | ADP + ? | - |
? | |
| ATP + [myosin light chain] | enzyme is regulating cytoskeletal rearrangement and cell motility | Homo sapiens | ADP + [myosin light chain] phosphate | - |
? | |
| ATP + [myosin light chain] | activated phosphorylated enzyme | Homo sapiens | ADP + [myosin light chain] phosphate | - |
? | |
| additional information | the enzyme mediates eosinophil chemotaxis in a mitogen-activated protein kinase-dependent manner | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MLCK | - |
Homo sapiens |
| myosin light chain kinase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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