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Literature summary for 2.7.11.18 extracted from

  • Watari, A.; Sakamoto, Y.; Hisaie, K.; Iwamoto, K.; Fueta, M.; Yagi, K.; Kondoh, M.
    Rebeccamycin attenuates TNF-alpha-induced intestinal epithelial barrier dysfunction by inhibiting myosin light chain kinase production (2017), Cell. Physiol. Biochem., 41, 1924-1934 .
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [myosin light chain] Homo sapiens
-
 ADP + [myosin light chain] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
-
 Homo sapiens
-
colorectal adenocarcinoma cell
-
 Homo sapiens
-
intestinal epithelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [myosin light chain]
-
 Homo sapiens ADP + [myosin light chain] phosphate
-
 ?

Synonyms

Synonyms Comment Organism
MLC kinase
-
 Homo sapiens
MLCK
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens rebeccamycin mediates reduction in enzyme production down
Homo sapiens tumor necrosis factor-alpha induces an increase in enzyme mRNA expression in intestinal epithelial cells up

General Information

General Information Comment Organism
physiological function the enzyme is essential for the increase in intestinal permeability induced by tumor necrosis factor-alpha Homo sapiens