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Literature summary for 2.7.11.18 extracted from

  • Christie, J.D.; Ma, S.F.; Aplenc, R.; Li, M.; Lanken, P.N.; Shah, C.V.; Fuchs, B.; Albelda, S.M.; Flores, C.; Garcia, J.G.
    Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma (2008), Crit. Care Med., 36, 2794-2800.
    View publication on PubMed
Search for more literature for 2.7.11.18

Cloned(Commentary)

Cloned (Comment) Organism
gene MYLK, DNA and amino acid sequence determination and analysis of wild-type and single nucleotide mutants, genotyping Homo sapiens

Protein Variants

Protein Variants Comment Organism
H21P naturally occuring single nucleotide polymorphism increasing the risk for acute lung injury within 5 das of traumatic insult Homo sapiens
additional information single nucleotide polymorphisms are involved in the risk of sepsis-related acute lung injury and asthma, haplotype analysis, overview Homo sapiens
P147S naturally occuring single nucleotide polymorphism increasing the risk for acute lung injury within 5 das of traumatic insult Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme is involved in inflammation response, including apoptosis, vascular permeability, and leukocyte diapedesis. Single nucleotide polymorphisms are involved in the risk of sepsis-related acute lung injury and asthma ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 gene MYLK encoding several isozymes
-

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
-
 Homo sapiens
-
lung
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is involved in inflammation response, including apoptosis, vascular permeability, and leukocyte diapedesis. Single nucleotide polymorphisms are involved in the risk of sepsis-related acute lung injury and asthma Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
MYLK
-
 Homo sapiens
myosin light chain kinase
-
 Homo sapiens