Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ML-7 | 40-60% inhibition in vivo | Homo sapiens | |
W-7 | 40-60% inhibition in vivo | Homo sapiens | |
Y-27632 | 40-60% inhibition in vivo | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + light chain myosin II | Homo sapiens | the enzyme is important in regulation of shape, adhesion and migration of fibrosarcoma cells, overview | ADP + phosphorylated light chain myosin II | - |
? | |
additional information | Homo sapiens | inhibition of MLCK results in spherical cells and marked impairment of adhesion and migration of fibrosarcoma cells, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HT-1080 cell | a fibrosarcoma cell line | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + light chain myosin II | the enzyme is important in regulation of shape, adhesion and migration of fibrosarcoma cells, overview | Homo sapiens | ADP + phosphorylated light chain myosin II | - |
? | |
ATP + light chain myosin II | regulatory myosin chain, phosphorylation at Ser18 and Thr19 on the N-terminus | Homo sapiens | ADP + phosphorylated light chain myosin II | - |
? | |
additional information | inhibition of MLCK results in spherical cells and marked impairment of adhesion and migration of fibrosarcoma cells, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MLCK | - |
Homo sapiens |
myosin light chain kinase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |