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Information on EC 2.7.11.18 - myosin-light-chain kinase
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2.7.11.18 myosin-light-chain kinaseIUBMB Comments
Requires Ca2+ and calmodulin for activity. The 20-kDa light chain from smooth muscle myosin is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors, but more slowly.
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Word Map
- 2.7.11.18
-
contractile
- actin
- junction
- artery
- rho
- pkc
- agonist
- gizzard
- cytoskeletal
- actomyosin
-
tension
- occludin
-
rock
-
calmodulin-binding
-
actin-activated
-
isometric
-
rho-associated
- mlc20
-
paracellular
-
ca2+-independent
-
actin-myosin
-
rho-kinase
- wortmannin
-
zonula
- mypt1
-
cam-binding
-
actin-binding
-
cam-dependent
- trifluoperazine
- caldesmon
-
myofilament
-
hyperpermeability
-
thrombin-induced
-
thiophosphorylation
- mg2+-atpase
- calyculin
-
pseudosubstrate
- blebbistatin
- idella
-
diphosphorylation
- calponin
-
cross-bridge
- meromyosin
- medicine
-
mgatpase
-
myosin-binding
-
monoxime
-
n-6-aminohexyl-5-chloro-1-naphthalenesulfonamide
-
calmodulin-activated
-
superprecipitation
- cak
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
mlck, myosin light chain kinase, myosin light-chain kinase, mlc kinase, smooth muscle myosin light chain kinase, smmlck, nmmlck, myosin kinase, cmlck, skmlck, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Ca2+-dependent kinase myosin light chain kinase
calcium/calmodulin-dependent myosin light chain kinase
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-
-
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cardiac myosin light chain kinase
cardiac-MLCK
cMLCK
DNA-dependent protein kinase catalytic subunit
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EC 2.7.1.117
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-
formerly
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endothelial MLCK
endothelial myosin light chain kinase
im:7148400
kinase, myosin light-chain (phosphorylating)
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MLC kinase
MLCK
MLCK-210
MYLK
Mylk3
mylk5
myosin kinase
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-
-
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myosin light chain kinase
myosin light chain kinase, smooth muscle
myosin light chain kinase, smooth muscle and non-muscle isozymes
myosin light chain protein kinase
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-
-
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myosin light-chain kinase
myosine light chain kinase
nmMLCK
non-muscle myosin light chain kinase
obscurin-associated kinase
obscurin-MLCK-like kinase
smMLCK
smooth muscle myosin light chain kinase
smooth-muscle-myosin-light-chain kinase
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-
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additional information
MLCK
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-
MLCK
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MLCK
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myosin light chain kinase
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myosin light chain kinase
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myosin light chain kinase
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myosin light chain kinase
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myosin light chain kinase, smooth muscle and non-muscle isozymes
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myosin light-chain kinase
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-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
ATP + [myosin light chain] = ADP + [myosin light chain] phosphate
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
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-
-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP:[myosin light chain] O-phosphotransferase
Requires Ca2+ and calmodulin for activity. The 20-kDa light chain from smooth muscle myosin is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors, but more slowly.
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CAS REGISTRY NUMBER
COMMENTARY
51845-53-5
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + 20kDa myosin light chain
ADP + 20kDa myosin light chain phosphate
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phosphorylation occurs at Ser-19 and Thr-18
-
-
?
ATP + BpaKKRAARATSNVFA
ADP + ?
-
Bpa is the photoreactive amino acid p-benzoylphenylalanine
-
-
?
ATP + Dictyostelium myosin
ADP + Dictyostelium myosin phosphate
-
-
-
?
ATP + kemptamide
ADP + kemptamide phosphate
i.e. peptide KKRPQRATSNVFS-NH2, activated enzyme
-
-
?
ATP + myosin II
ADP + myosin II phosphate
from Dictyostelium discoideum, activated enzyme
-
-
?
ATP + myosin regulatory light chain
ADP + phosphorylated myosin regulatory light chain
-
-
-
-
?
ATP + myosin-II regulatory light chain
ADP + myosin-II regulatory light chain phosphate
-
-
-
-
?
ATP + TRPC5 channel
ADP + phosphorylated TRPC5 channel
Ca2+/calmodulin-dependent myosin light chain kinase is essential for activation of plasma membrane TRPC5 channels, responsible for Ca2+ influx, from Drosophila melanogaster expressed in HEK-293 cells, phosphorylation sites are Ser698, Ser775, and Thr700, mutational analysis
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-
?
ATP + [myosin II light chain]
ADP + [myosin II lihght chain] phosphate
from Dictyostelium discoideum, activated enzyme
-
-
?
ATP + [myosin II regulatory light chain]
ADP + [myosin II regulatory light chain] phosphate
ATP + [non-muscle heavy meromyosin IIB]
ADP + [non-muscle heavy meromyosin IIB] phosphate
-
-
-
?
ATP + [non-muscle regulatory light chain]
ADP + [non-muscle regulatory light chain] phosphate
-
-
-
?
ATP + [rabbit white skeletal muscle myosin P-light chain]
ADP + [rabbit white skeletal muscle myosin P-light chain] phosphate
-
-
-
-
?
ATP + [smooth muscle heavy meromyosin]
ADP + [smooth muscle heavy meromyosin] phosphate
-
-
-
?
ATP + [smooth muscle regulatory light chain]
ADP + [smooth muscle regulatory light chain] phosphate
-
-
-
?
ATP + [ventricular isoform of myosin regulatory light chain MLC2v]
ADP + [ventricular isoform of myosin regulatory light chain MLC2v] phosphate
-
-
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
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causes endothelial contraction
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
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cardiac-MLCK is essential for normal cardiac development and function in zebrafish embryos, deletion of the gene encoding cardiac-MLCK is lethal for embryos
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-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
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the cardiac-specific substrate cardiac-MLCKis phosphorylated by the cardiac-specific isozyme MLC2v
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-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
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-
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
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cytokine-induced epithelial barrier dysfunction can be mediated by increased MLCK expression and subsequent myosin II regulatory light chain phosphorylation, the enzyme is involved in the inflammatory bowel disease
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-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
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the enzyme is important in regulation of shape, adhesion and migration of fibrosarcoma cells, overview
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-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
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regulatory myosin chain, phosphorylation at Ser18 and Thr19 on the N-terminus
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
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regulatory myosin light chain
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-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
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the cardiac-specific substrate MLC2v is phosphorylated by the cardiac-specific isozyme cardiac-MLCK
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-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
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roles of MLCK and ROCK on myosin II activation, overview, a global, MLCK-dependent increase in myosin II cortical contractility accompanies the metaphase-anaphase transition in sea urchin eggs, overview
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-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
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phosphorylation at Ser19
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
-
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
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MLCK plays a key role in the control of MLC-phosphorylation status, and it modulates barrier function through its regulation of intracellular contractile machinery, overview, endothelial mechanism of MLC-dependent barrier injury in burns, overview
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-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
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myosin II activation is essential for stress fiber and focal adhesion formation, and is implicated in integrin-mediated signaling events
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
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MLC phosphorylation increases muscle contraction and plays a prominent role in skeletal muscle force potentiation of fast-twitch type IIb but not type I or IIa fibers, overview
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
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regulatory myosin chain, in thick filaments, isozyme L-MLCK plays a role in cytoskeleton organization
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
regulatory myosin chain
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
regulatory myosin chain, phosphorylation at Ser18 and Thr19 on the N-terminus
-
-
?
ATP + light chain myosin II
ADP + phosphorylated light chain myosin II
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
-
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle myosin
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?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrates are myosin heavy chain and phosvitin
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?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrates are myosin heavy chain and phosvitin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
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?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
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?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
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?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
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?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of skeletal muscle
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
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acceptor substrates are myosin light chains of cardiac muscle
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?
ATP + myosin light chain
ADP + myosin light chain phosphate
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acceptor substrates are myosin light chains of cardiac muscle
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?
ATP + myosin light chain
ADP + myosin light chain phosphate
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acceptor substrates are myosin light chains of cardiac muscle
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?
ATP + myosin light chain
ADP + myosin light chain phosphate
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no substrate is histone 2-A
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?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is histone 2-A
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?
ATP + myosin light chain
ADP + myosin light chain phosphate
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acceptor substrates are myosin light chains of non-muscle myosin
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-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
not specific for 22 kDa and 15 kDa light chain
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-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is casein
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain
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?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Thr-residues in smooth muscle and pancreas myosin light chain
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?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
phosphorylation sites: Ser-residues in smooth and skeletal muscle
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?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of adrenal medullary myosin
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?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is histone 2 b
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is troponin
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for regulatory or P-light-chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for regulatory or P-light-chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for regulatory or P-light-chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for 18 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
highly specific for 18 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is synapsin
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
1 mol phosphate per mol light chain in skeletal muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase kinase
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
no substrate is phosphorylase kinase
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
acceptor substrates are myosin light chains of smooth muscle
-
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?
ATP + myosin light chain
ADP + myosin light chain phosphate
-
specific for 20 kDa light chain
-
?