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Literature summary for 2.7.11.18 extracted from

  • Burbank, M.G.; Burban, A.; Sharanek, A.; Weaver, R.J.; Guguen-Guillouzo, C.; Guillouzo, A.
    Early alterations of bile canaliculi dynamics and the Rho kinase/myosin light chain kinase pathway are characteristics of drug-induced intrahepatic cholestasis (2016), Drug Metab. Dispos., 44, 1780-1793 .
    View publication on PubMed
Search for more literature for 2.7.11.18

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
bosentan
-
 Homo sapiens
cimetidine
-
 Homo sapiens
diclofenac
-
 Homo sapiens
entacapone
-
 Homo sapiens
tacrolimus
-
 Homo sapiens
tolcapone
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [myosin light chain] Homo sapiens
-
 ADP + [myosin light chain] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hepa-RG cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [myosin light chain]
-
 Homo sapiens ADP + [myosin light chain] phosphate
-
 ?

Synonyms

Synonyms Comment Organism
MLCK
-
 Homo sapiens