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Information on EC 2.6.1.43 - aminolevulinate transaminase
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EC Tree
2.6.1.43 aminolevulinate transaminaseIUBMB Comments
A pyridoxal-phosphate protein.
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Word Map
- 2.6.1.43
-
2.6.1.19
- 4-aminobutyrate
- gaba-t
-
4.1.1.15
- hyperoxaluria
-
alanine:glyoxylate
-
delta-aminolevulinic
-
l-alanine:4,5-dioxovalerate
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1.2.1.16
-
4-aminobutyrate:2-oxoglutarate
- gaba-transaminase
- medicine
-
gamma-vinyl
- porphobilinogenase
- gabaculine
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
dova transaminase, dova-t, 4,5-dioxovalerate aminotransferase, alanine:4,5-dioxovalerate aminotransferase, 4,5-dioxovaleric acid transaminase, l-alanine:4,5-dioxovaleric acid transaminase, 4,5-dioxovaleric acid aminotransferase, aminolevulinate aminotransferase, gamma,delta-dioxovalerate aminotransferase, dioxovalerate transaminase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
4,5-dioxovalerate aminotransferase
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4,5-dioxovaleric acid aminotransferase
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4,5-dioxovaleric acid transaminase
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4,5-dioxovaleric transaminase
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5-aminolevulinic acid transaminase
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alanine-dioxovalerate aminotransferase
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alanine-gamma,delta-dioxovalerate aminotransferase
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alanine:4,5-dioxovalerate aminotransferase
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aminolevulinate aminotransferase
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aminolevulinic acid transaminase
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dioxovalerate transaminase
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DOVA transaminase
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EC 2.6.1.19
EC 2.6.1.40
EC 2.6.1.44
gamma,delta-dioxovalerate aminotransferase
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gamma,delta-dioxovaleric acid transaminase
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L-alanine-4,5-dioxovalerate aminotransferase
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L-alanine:4,5-dioxovaleric acid transaminase
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L-alanine:dioxovalerate transaminase
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EC 2.6.1.19
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2-aminobutyrate aminotransferase and aminolevulinate transaminase activity reside in the same protein
EC 2.6.1.19
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2-aminobutyrate aminotransferase and aminolevulinate transaminase activity reside in the same protein
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EC 2.6.1.40
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dimethylarginine-pyruvate aminotransferase and D-3-aminoisobutyrate pyruvate aminotransferase activities resides in the same protein
EC 2.6.1.40
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dimethylarginine-pyruvate aminotransferase and D-3-aminoisobutyrate pyruvate aminotransferase activities resides in the same protein
EC 2.6.1.40
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dimethylarginine-pyruvate aminotransferase and D-3-aminoisobutyrate pyruvate aminotransferase activities resides in the same protein
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EC 2.6.1.44
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alanine-glyoxylate transaminase and aminolevulinate transaminase activities reside in the same protein
EC 2.6.1.44
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alanine-glyoxylate transaminase and aminolevulinate transaminase activities reside in the same protein
EC 2.6.1.44
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alanine-glyoxylate transaminase and aminolevulinate transaminase activities reside in the same protein
EC 2.6.1.44
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alanine-glyoxylate transaminase and aminolevulinate transaminase activities reside in the same protein
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
5-aminolevulinate + pyruvate = 4,5-dioxopentanoate + L-alanine
A pyridoxal-phosphate protein
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
amino group transfer
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-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
5-aminolevulinate:pyruvate aminotransferase
A pyridoxal-phosphate protein.
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CAS REGISTRY NUMBER
COMMENTARY
9012-46-8
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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3% of the activity with L-alanine
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ir
DL-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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89% of the activity with L-alanine
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ir
L-arginine + 4,5-dioxopentanoate
5-aminolevulinate + 5-guanidino-2-oxopentanoate
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6.8% of the activity with L-alanine
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ir
L-asparagine + 4,5-dioxopentanoate
5-aminolevulinate + 4-amino-2,4-dioxobutanoic acid
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74% of the activity with L-alanine
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ir
L-histidine + 4,5-dioxopentanoate
5-aminolevulinate + 3-(1H-imidazol-4-yl)-2-oxopropanoate
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74% of the activity with L-alanine
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ir
beta-alanine + 4,5-dioxopentanoate
5-aminolevulinate + malonic semialdehyde
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23% of the activity with L-alanine
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ir
beta-alanine + 4,5-dioxopentanoate
5-aminolevulinate + malonic semialdehyde
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39% of the activity with L-alanine
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ir
beta-alanine + 4,5-dioxopentanoate
5-aminolevulinate + malonic semialdehyde
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65.6% of the activity with L-alanine
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ir
delta-amino-n-valerate + 4,5-dioxopentanoate
5-aminolevulinate + 5-oxo-n-pentanoate
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10% of the activity with L-alanine
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ir
delta-amino-n-valerate + 4,5-dioxopentanoate
5-aminolevulinate + 5-oxo-n-pentanoate
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transaminate at 95% of the rate of alpha-alanine
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ir
epsilon-amino-n-caproate + 4,5-dioxopentanoate
5-aminolevulinate + 6-oxo-n-hexanoate
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transaminate at 103% of the rate of alpha-alanine
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ir
epsilon-amino-n-caproate + 4,5-dioxopentanoate
5-aminolevulinate + 6-oxo-n-hexanoate
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34% of the activity with L-alanine
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ir
gamma-amino-n-butyrate + 4,5-dioxopentanoate
5-aminolevulinate + succinic semialdehyde
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10% of the activity with L-alanine
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ir
gamma-amino-n-butyrate + 4,5-dioxopentanoate
5-aminolevulinate + succinic semialdehyde
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transaminate at 122% of the rate of alpha-alanine
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ir
gamma-amino-n-butyrate + 4,5-dioxopentanoate
5-aminolevulinate + succinic semialdehyde
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55% of the activity with L-alanine
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ir
glycine + 4,5-dioxopentanoate
5-aminolevulinate + glyoxylate
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9% of the activity with L-alanine
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ir
glycine + 4,5-dioxopentanoate
5-aminolevulinate + glyoxylate
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-
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ir
glycine + 4,5-dioxopentanoate
5-aminolevulinate + glyoxylate
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less than 10% of the activity of alpha-alanine
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ir
glycine + 4,5-dioxopentanoate
5-aminolevulinate + glyoxylate
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21% of the activity with L-alanine
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ir
glycine + 4,5-dioxopentanoate
5-aminolevulinate + glyoxylate
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21% of the activity with L-alanine
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ir
glycine + 4,5-dioxopentanoate
5-aminolevulinate + glyoxylate
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81.2% of the activity with L-alanine
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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biosynthesis of porphyrin precursors
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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-
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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-
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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-
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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-
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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-
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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-
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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-
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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delta-aminolevulinate pathway
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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first committed step in heme synthesis
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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alternate route for delta-aminolevulinate formation
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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heme biosynthetic pathway
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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heme biosynthetic pathway
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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heme biosynthetic pathway
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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-
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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heme biosynthetic pathway
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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-
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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-
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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alternate route for delta-aminolevulinate formation
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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heme biosynthetic pathway
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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-
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ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
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-
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ir
L-aspartate + 4,5-dioxopentanoate
5-aminolevulinate + oxaloacetate
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39% of the activity with L-alanine
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ir
L-aspartate + 4,5-dioxopentanoate
5-aminolevulinate + oxaloacetate
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67% of the activity with L-alanine
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ir
L-glutamate + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutarate
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39% of the activity with L-alanine
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ir
L-glutamate + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutarate
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39% of the activity with L-alanine
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ir
L-glutamate + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutarate
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37% of the activity with L-alanine
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ir
L-glutamate + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutarate
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37% of the activity with L-alanine
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ir
L-glutamate + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutarate
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96% of the activity with L-alanine
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ir
L-glutamate + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutarate
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43.8% of the activity with L-alanine
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ir
L-glutamine + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutaramate
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74% of the activity with L-alanine
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-
?
L-glutamine + 4,5-dioxopentanoate
5-aminolevulinate + 2-oxoglutaramate
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16% of the activity with L-alanine
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?
L-lysine + 4,5-dioxopentanoate
5-aminolevulinate + 6-amino-2-oxohexanoate
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9% of the activity with L-alanine
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ir
L-lysine + 4,5-dioxopentanoate
5-aminolevulinate + 6-amino-2-oxohexanoate
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15% of the activity with L-alanine
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ir
L-ornithine + 4,5-dioxopentanoate
5-aminolevulinate + 5-amino-2-oxopentanoate
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6% of the activity with L-alanine
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ir
L-ornithine + 4,5-dioxopentanoate
5-aminolevulinate + 5-amino-2-oxopentanoate
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less than 10% of the activity of alpha-alanine
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ir
L-ornithine + 4,5-dioxopentanoate
5-aminolevulinate + 5-amino-2-oxopentanoate
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14% of the activity with L-alanine
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ir
L-phenylalanine + 4,5-dioxopentanoate
phenylpyruvate + 5-aminolevulinate
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71% of the activity with L-alanine
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ir
L-phenylalanine + 4,5-dioxopentanoate
phenylpyruvate + 5-aminolevulinate
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90.6% of the activity with L-alanine
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ir
L-serine + 4,5-dioxopentanoate
5-aminolevulinate + 3-hydroxy-2-oxopropanoate
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33% of the activity with L-alanine
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ir
L-serine + 4,5-dioxopentanoate
5-aminolevulinate + 3-hydroxy-2-oxopropanoate
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33% of the activity with L-alanine
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-
ir
additional information
?
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glutamate is no substrate, transamination of methylglyoxal yields aminoacetone, less than 1% efficient as amino acceptor as 4,5-dioxopentanoate
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?
additional information
?
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cannot utilize 2-oxoglutarate nor pyruvate as amino acceptors
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?
additional information
?
-
-
cannot utilize 2-oxoglutarate nor pyruvate as amino acceptors
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-
?
additional information
?
-
-
ability of beta-alanine to replace alpha-alanine as amino group donor is lost during purification, alpha-amino-n-butyrate, alpha-aminoisobutyrate, beta-amino-n-butyrate and beta-aminoisobutyrate are inactive, serine, taurine, glutamine, asparagine, glutamic and aspartic acids, lysine and cysteine all have negligible activity
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-
?
additional information
?
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does not use 2-oxoglutarate as amino acceptor
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-
?
additional information
?
-
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does not use 2-oxoglutarate as amino acceptor
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-
?
additional information
?
-
-
L-lysine, L-arginine, L-glutamate, L-methionine, L-histidine, glycine, L-phenylalanine, L-threonine, L-asparagine, L-serine, L-proline, L-valine, L-isoleucine, L-leucine, L-tyrosine, L-cysteine and L-tryptophan are all inert as amino donors, methylglyoxal is a poor substrate for the enzyme
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-
?
additional information
?
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DL-alanine, D-alanine, ammonium sulfate, L-glutamate, glycine and phenylalanine cannot replace L-alanine
-
-
?
additional information
?
-
-
DL-alanine, D-alanine, ammonium sulfate, L-glutamate, glycine and phenylalanine cannot replace L-alanine
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
biosynthesis of porphyrin precursors
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
delta-aminolevulinate pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
first committed step in heme synthesis
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
alternate route for delta-aminolevulinate formation
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
heme biosynthetic pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
heme biosynthetic pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
heme biosynthetic pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
heme biosynthetic pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
alternate route for delta-aminolevulinate formation
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
heme biosynthetic pathway
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
L-alanine + 4,5-dioxopentanoate
5-aminolevulinate + pyruvate
-
-
-
ir
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
-
EDTA, N-ethylmaleimide. iodoacetic acid, cysteine and beta-mercaptoethanol are no inhibitors
-
additional information
-
iodoacetamide and chloroacetamide are not inhibitors
-
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Hyperoxaluria, Primary
Characterization and chromosomal mapping of a genomic clone encoding human alanine:glyoxylate aminotransferase.
Hyperoxaluria, Primary
Combined hepatic and renal transplantation in primary hyperoxaluria type I: clinical report of nine cases.
Hyperoxaluria, Primary
Crystal structure and confirmation of the alanine:glyoxylate aminotransferase activity of the YFL030w yeast protein.
Hyperoxaluria, Primary
Fetal liver alanine: glyoxylate aminotransferase and the prenatal diagnosis of primary hyperoxaluria type 1.
Hyperoxaluria, Primary
Further studies on the activity and subcellular distribution of alanine:glyoxylate aminotransferase in the livers of patients with primary hyperoxaluria type 1.
Hyperoxaluria, Primary
Immunocytochemical localization of human hepatic alanine: glyoxylate aminotransferase in control subjects and patients with primary hyperoxaluria type 1.